Results 21 to 30 of about 10,284 (252)
The Involvement of TRPC3 channels in Sinoatrial Arrhythmias
Frontiers in Physiology, 2015 Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge.
Yue-Kun eJu +6 more
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Key Components of Store-Operated Ca2+ Entry in Non-Excitable Cells
Journal of Pharmacological Sciences, 2014 .: Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ entry pathway in non-excitable cells. It is activated by the depletion of Ca2+ from intracellular Ca2+ stores, notably the endoplasmic reticulum (ER).
Yosuke Tojyo +3 more
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Regulation of store-operated Ca2+ entry during the cell cycle [PDF]
Journal of Cell Science, 2010 Cytoplasmic Ca2+ signals are central to numerous cell physiological processes, including cellular proliferation. Historically, much of the research effort in this area has focused on the role of Ca2+ signals in cell-cycle progression. It is becoming clear, however, that the relationship between Ca2+ signaling and the cell cycle is a ‘two-way street ...
Abdelilah, Arredouani +3 more
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PLoS ONE, 2014 Ca2+ entry into airway epithelia is important for activation of the NFAT family of transcription factors and expression of genes including epidermal growth factor that help orchestrate local inflammatory responses. However, the identity of epithelial Ca2+
Krishna Samanta +2 more
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STIM2 Is an Inhibitor of STIM1-Mediated Store-Operated Ca2+ Entry [PDF]
Current Biology, 2006 The coupling mechanism between endoplasmic reticulum (ER) Ca(2+) stores and plasma membrane (PM) store-operated channels (SOCs) remains elusive [1-3]. STIM1 was shown to play a crucial role in this coupling process [4-7]; however, the role of the closely related STIM2 protein remains undetermined.
Soboloff, Jonathan +7 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Activation of stromal interaction molecule 1 (STIM1) and Orai1 participates in the development of cardiac hypertrophy. Store-operated Ca2+ entry-associated regulatory factor (SARAF) is an intrinsic inhibitor of STIM1-Orai1 interaction ...
Fengdan Dai +6 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Upon Ca2+ store depletion, stromal interaction molecule 1 (STIM1) oligomerizes, redistributes near plasmalemma to interact with Ca2+ selective channel-forming subunit (Orai1) and initiates store-operated Ca2+ entry (SOCE).
Shu Li +9 more
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Frontiers in Cell and Developmental Biology, 2021 One of the major Ca2+ signaling pathways is store-operated Ca2+ entry (SOCE), which is responsible for Ca2+ flow into cells in response to the depletion of endoplasmic reticulum Ca2+ stores.
Ewelina Latoszek, Magdalena Czeredys
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Ca2+-independent Phospholipase A2 Is a Novel Determinant of Store-operated Ca2+ Entry [PDF]
Journal of Biological Chemistry, 2003 Store-operated cation (SOC) channels and capacitative Ca(2+) entry (CCE) play very important role in cellular function, but the mechanism of their activation remains one of the most intriguing and long lasting mysteries in the field of Ca(2+) signaling.
Tarik, Smani +5 more
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STIM1 regulates store-operated Ca2+ entry in oocytes
Developmental Biology, 2009 The single transmembrane-spanning Ca(2+)-binding protein, STIM1, has been proposed to function as a Ca(2+) sensor that links the endoplasmic reticulum to the activation of store-operated Ca(2+) channels. In this study, the presence, subcellular localization and function of STIM1 in store-operated Ca(2+) entry in oocytes was investigated using the pig ...
Koh, Sehwon +4 more
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