Results 21 to 30 of about 12,900 (288)

Regulation of Store-Operated Ca²⁺ Entry by SARAF. [PDF]

Cells, 2021
Calcium (Ca2+) signaling plays a dichotomous role in cellular biology, controlling cell survival and proliferation on the one hand and cellular toxicity and cell death on the other. Store-operated Ca2+ entry (SOCE) by CRAC channels represents a major pathway for Ca2+ entry in non-excitable cells. The CRAC channel has two key components, the endoplasmic
Dagan I, Palty R.
europepmc   +5 more sources

Regulation of store-operated Ca²⁺ entry by IP₃ receptors independent of their ability to release Ca². [PDF]

Elife, 2023
Loss of endoplasmic reticular (ER) Ca2+ activates store-operated Ca2+ entry (SOCE) by causing the ER localized Ca2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS).
Chakraborty P, Deb BK, Arige V, Musthafa T, Malik S, Yule DI, Taylor CW, Hasan G.   +7 more
europepmc   +7 more sources

S-acylation of Orai1 regulates store-operated Ca2+ entry. [PDF]

J Cell Sci, 2022
ABSTRACT Store-operated Ca2+ entry is a central component of intracellular Ca2+ signaling pathways. The Ca2+ release-activated channel (CRAC) mediates store-operated Ca2+ entry in many different cell types. The CRAC channel is composed of the plasma membrane (PM)-localized Orai1 channel and endoplasmic reticulum (ER)-localized STIM1 Ca2+
West SJ, Kodakandla G, Wang Q, Tewari R, Zhu MX, Boehning D, Akimzhanov AM.   +6 more
europepmc   +3 more sources

Lysosomal agents inhibit store-operated Ca²⁺ entry. [PDF]

J Cell Sci, 2021
Pharmacological manipulation of lysosome membrane integrity or ionic movements is a key strategy for probing lysosomal involvement in cellular processes. However, we have found an unexpected inhibition of store-operated Ca2+ entry (SOCE) by these agents. Dipeptides (GPN and LLOMe) that are inducers of lysosomal membrane permeabilization (LMP) uncoupled
Morgan AJ, Galione A.
europepmc   +3 more sources

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]

, 2004
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Arnoult, Christophe, Cristiano Grasso, Treves, Susan, Ronjat, Michel, Mikoshiba, Katsuhiko, ARNOULT C, GRASSO C, TREVES, Susan Nella, Ducreux, Sylvie, DUCREUX S, Smida-Rezgui, Sophia, Franzini-Armstrong, Clara, MIKOSHIBA K, SCHRUM A, Sylvie Ducreux, Susan Treves, RONJAT M, Grasso, Cristiano, Zhu, Michael X., Zorzato, Francesco, SMIDA REZGUI S, Sophia Smida-Rezgui, MOCCAGATTA L, Zhu, Michael, Francesco Zorzato, Clara Franzini-Armstrong, Christophe Arnoult, Luca Moccagatta, Schrum, Adam, Michel Ronjat, ZHU MX, GIRARD T, Girard, Thierry, Katsuhiko Mikoshiba, Thierry Girard, FRANZINI ARMSTRONG C, Moccagatta, Luca, Michael X. Zhu, Adam Schrum   +38 more
core   +1 more source

Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes [PDF]

, 2009
In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP2) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles [PDF]

, 2016
We exploited a variety of mouse models to assess the roles of JP45-CASQ1 (CASQ, calsequestrin) and JP45-CASQ2 on calcium entry in slow twitch muscles.
Treves S, Treves, Susan, TREVES, Susan Nella, Protasi F, De Negri M4, Bongianino, Rossana, Bergamelli L, De Negri M, Bongianino R4, Mosca B, Priori, Silvia G., Priori SG, Zorzato, Francesco, Eckhardt J, Eckhardt, Jan, Mosca, Barbara, Bergamelli, Leda, Protasi F6, PRIORI, SILVIA GIULIANA, Zorzato F, De Negri, Marco, Eckhardt J2, Protasi, Feliciano, Bongianino R, Priori SG5   +24 more
core   +1 more source

The Involvement of TRPC3 channels in Sinoatrial Arrhythmias

Frontiers in Physiology, 2015
Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge.
Yue-Kun eJu, Bon Hyang Lee, Sofie eTrajanovska, Guoliang eHao, David G Allen, Ming eLei, Mark B Cannell   +6 more
doaj   +1 more source

Calcium Transport in Specialized Dental Epithelia and Its Modulation by Fluoride

Frontiers in Endocrinology, 2021
Most cells use calcium (Ca2+) as a second messenger to convey signals that affect a multitude of biological processes. The ability of Ca2+ to bind to proteins to alter their charge and conformation is essential to achieve its signaling role.
Veronica Costiniti, Guilherme H. Bomfim, Erna Mitaishvili, Ga-Yeon Son, Yi Li, Rodrigo S. Lacruz   +5 more
doaj   +1 more source

Studies on the role of Coronin 1 and the actin cytoskeleton in T cell signaling and survival [PDF]

, 2009
Calcium ions (Ca2+) function as universal second messengers in most if not all eukaryotic cells, including the cells of the immunesystem. Ca2+ signals are required for the proper activation of lymphocytes, such as T-lymphocytes, their proliferation ...
Müller, Philipp
core   +1 more source