Results 11 to 20 of about 10,284 (252)
TRPC channels and store-operated Ca2+ entry
Biochimica Et Biophysica Acta - Molecular Cell Research, 2009 Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) influx. Since SOCE was first proposed two decades ago many techniques have been used in attempting to identify the nature of store-operated Ca(2+) (SOC) channels. The first identified and best-characterised store-operated current is I(CRAC), but a number of other currents activated by ...
Stewart Sage +2 more
exaly +3 more sources
Lithium- Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release
Neurosignals, 2015 Background/Aims: Lithium, a widely used drug for the treatment of mood disorders, has previously been shown to stimulate the release of fibroblast growth factor FGF23, a powerful regulator of 1,25(OH)2D3 formation and mineral metabolism.
Bingbing Zhang +6 more
doaj +4 more sources
Molecular Determinants for STIM1 Activation During Store- Operated Ca2+ Entry. [PDF]
Curr Mol Med, 2017 STIM/ORAI-mediated store-operated Ca2+ entry (SOCE) mediates a myriad of Ca2+-dependent cellular activities in mammals. Genetic defects in STIM1/ORAI1 lead to devastating severe combined immunodeficiency; whereas gain-offunction mutations in STIM1/ORAI1 are intimately associated with tubular aggregate myopathy. At molecular level, a decrease in the Ca2+
Ma G +7 more
europepmc +4 more sources
Caffeine-induced Ca2+ oscillations in type I horizontal cells of the carp retina and the contribution of the store-operated Ca2+ entry pathway. [PDF]
PLoS ONE, 2014 The mechanisms of release, depletion, and refilling of endoplasmic reticulum (ER) Ca2+ were investigated in type I horizontal cells of the carp retina using a fluo-3-based Ca2+ imaging technique.
Ting Lv, Hai-Qing Gong, Pei-Ji Liang
doaj +1 more source
Frontiers in Physiology, 2023 Thapsigargin (TG) inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump and, when applied acutely, it initiates a Ca2+ mobilisation that begins with the loss of Ca2+ from the endoplasmic reticulum (ER) and culminates with store-operated Ca2 ...
Tillman Pick +3 more
doaj +1 more source
Store‐operated Ca2+ entry depends on mitochondrial Ca2+ uptake [PDF]
The EMBO Journal, 2002 Store-operated Ca(2+) channels, which are activated by the emptying of intracellular Ca(2+) stores, provide one major route for Ca(2+) influx. Under physiological conditions of weak intracellular Ca(2+) buffering, the ubiquitous Ca(2+) releasing messenger InsP(3) usually fails to activate any store-operated Ca(2+) entry unless mitochondria are ...
Glitsch, M, Bakowski, D, Parekh, A
openaire +2 more sources
Journal of Pharmacological Sciences, 2007 ATP-receptor (P2Y) stimulation induced sustained Ca2+-entry, which was essential for the enhanced cell-proliferation in t-BBEC117, an immortalized cell-line derived from bovine brain endothelial cells.
Daiju Yamazaki +3 more
doaj +1 more source
Shaped by leaky ER: Homeostatic Ca2+ fluxes
Frontiers in Physiology, 2022 At any moment in time, cells coordinate and balance their calcium ion (Ca2+) fluxes. The term ‘Ca2+ homeostasis’ suggests that balancing resting Ca2+ levels is a rather static process.
Annemarie Schulte +2 more
doaj +1 more source
Lafutidine-Induced Increase in Intracellular Ca2+ Concentrations in PC12 and Endothelial Cells
Journal of Pharmacological Sciences, 2005 Lafutidine, a histamine H2 receptor antagonist, exerts gastroprotective effects in addition to gastric antisecretory activity. The gastrointestinal protective effects of lafutidine are mediated by capsaicin-sensitive neurons, where capsaicin excites ...
Kana Kunieda +4 more
doaj +1 more source
Calcium Transport in Specialized Dental Epithelia and Its Modulation by Fluoride
Frontiers in Endocrinology, 2021 Most cells use calcium (Ca2+) as a second messenger to convey signals that affect a multitude of biological processes. The ability of Ca2+ to bind to proteins to alter their charge and conformation is essential to achieve its signaling role.
Veronica Costiniti +5 more
doaj +1 more source