Results 41 to 50 of about 5,913 (199)
TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
doaj +1 more source
Olhares & Trilhas, 2017 O objetivo deste número da Olhares & Trilhas é fornecer a pesquisadores e educadores subsídios para o trabalho com os gêneros orais . É, portanto, um número temático sobre gêneros textuais ou discursivos orais, organizado a partir de estudos realizados pelo Grupo de Pesquisa sobre Texto e Discurso (PETEDI) e outros pesquisadores,
Luiz Carlos Travaglia, Claudia Goulart
openaire +1 more source
ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension [PDF]
, 2018 Pulmonary hypertension is a complex and fatal disease that lacks treatments. Its pathophysiology involves pulmonary artery hyperreactivity, endothelial dysfunction, wall remodelling, inflammation, and thrombosis, which could all depend on ORAI Ca2 ...
Marthan, R +14 more
core +1 more source
USING ORAI APPLICATION IN TEACHING PRONUNCIATION
Indonesian EFL Journal, 2019 Teaching in 4.0 era cannot be separated with Information and Communication Technology (ICT). There are many applications that can be used in learning and teaching process.
Lilis Suryani +2 more
doaj +1 more source
Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia
Pulmonary Circulation, 2020 Obstructive sleep apnea (OSA), a breathing disorder featured by chronic intermittent hypoxia (CIH) is associated with pulmonary hypertension (PH). Rodents exposed to CIH develop pulmonary vascular remodeling and PH, but the pathogenic mechanisms are not ...
Sebastian Castillo-Galán +4 more
doaj +1 more source
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
Functional Role of STIM-1 and Orai1 in Human Microvascular Aging
Cells, 2022 The impact of aging on vascular function is heterogeneous depending on the vascular territories. Calcium regulation plays a key role in vascular function and has been implicated in aging-related hypercontractility of corpus cavernosum.
Mariam El Assar +8 more
doaj +1 more source
Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease
Arthritis &Rheumatology, EarlyView.Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel +12 more
wiley +1 more source
Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site [PDF]
Nature Communications, 2014 STIM1 and STIM2 are widely expressed endoplasmic reticulum (ER) Ca(2+) sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane Orai Ca(2+) channels. Although they are structurally similar, we reveal critical differences in the function of the short STIM-Orai-activating regions (SOAR) of STIM1 and ...
Wang, Xizhuo +8 more
openaire +3 more sources