Results 41 to 50 of about 4,465 (176)
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, EarlyView.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
The remote allosteric control of Orai channel gating.
PLoS Biology, 2019 Calcium signals drive an endless array of cellular responses including secretion, contraction, transcription, cell division, and growth. The ubiquitously expressed Orai family of plasma membrane (PM) ion channels mediate Ca2+ entry signals triggered by ...
Yandong Zhou +5 more
doaj +1 more source
Frontiers in Physiology, 2014 Store-operated calcium (Ca2+) entry (SOCE) can be mediated by two novel proteins, STIM/Orai. We have previously demonstrated that members of the TRPC family, putative basal and store operated calcium entry channels, are present in human myometrium and ...
Evonne eChin-Smith +3 more
doaj +1 more source
Communications Biology, 2023 Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties, such as Ca2+ signaling pathways, remain unexplored.
Braxton Phillips +3 more
doaj +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT Although the use of AI technologies (e.g., chatbots and automated writing evaluations (AWE)) has gained considerable attention in language learning fields in recent years, how AI technologies have been designed and implemented in language learning education, as well as their effectiveness, is understudied.
Shen Qiao +2 more
wiley +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow
The Journal of Physiology, EarlyView.Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley +1 more source
Olhares & Trilhas, 2017 O objetivo deste número da Olhares & Trilhas é fornecer a pesquisadores e educadores subsídios para o trabalho com os gêneros orais . É, portanto, um número temático sobre gêneros textuais ou discursivos orais, organizado a partir de estudos realizados pelo Grupo de Pesquisa sobre Texto e Discurso (PETEDI) e outros pesquisadores,
Luiz Carlos Travaglia, Claudia Goulart
openaire +1 more source
Target Molecules of STIM Proteins in the Central Nervous System
Frontiers in Molecular Neuroscience, 2020 Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER). They serve as calcium ion (Ca2+) sensors within the ER.
Karolina Serwach +1 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington +4 more
wiley +1 more source