Results 21 to 30 of about 5,913 (199)
Exploration of Immunology, 2023 Aim: Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease. Thymic stromal lymphopoietin (TSLP) is highly expressed in the epidermis of patients with AD and induces T helper 2 (Th2) immune responses and itching.
Masanori Fujii +7 more
doaj +1 more source
The Impact of Mutation L138F/L210F on the Orai Channel: A Molecular Dynamics Simulation Study
Frontiers in Molecular Biosciences, 2021 The calcium release-activated calcium channel, composed of the Orai channel and the STIM protein, plays a crucial role in maintaining the Ca2+ concentration in cells.
Xiaoqian Zhang +6 more
doaj +1 more source
Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart
Biology Open, 2020 Store-operated Ca2+ entry (SOCE) is an essential Ca2+ signaling mechanism present in most animal cells. SOCE refers to Ca2+ influx that is activated by depletion of sarco/endoplasmic reticulum (S/ER) Ca2+ stores.
Courtney E. Petersen +2 more
doaj +1 more source
Orai channel pharmacological manipulation reduces metabolic flexibility in cardiac fibroblasts. [PDF]
Am J Physiol Cell PhysiolCardiac fibroblasts (CFs) play a crucial role in regulating normal heart function and are also involved in the pathological remodeling of the heart that occurs due to hypertension, myocardial infarction, and heart failure.
Pantoja Newman PDS +4 more
europepmc +2 more sources
Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
eLife, 2021 The dimeric ER Ca2+ sensor STIM1 controls store-operated Ca2+ entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane.
Stijn van Dorp +7 more
doaj +1 more source
Transmembrane Domain 3 (TM3) Governs Orai1 and Orai3 Pore Opening in an Isoform-Specific Manner
Frontiers in Cell and Developmental Biology, 2021 STIM1-mediated activation of calcium selective Orai channels is fundamental for life. The three Orai channel isoforms, Orai1-3, together with their multiple ways of interplay, ensure their highly versatile role in a variety of cellular functions and ...
Adéla Tiffner +7 more
doaj +1 more source
Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening. [PDF]
Protein SciAbstract The calcium (Ca2+) channel Orai1—the pore‐forming subunit of the Ca2+ release‐activated Ca2+ channel—is opened by its physiological activator, the endoplasmic reticulum (ER)‐resident Ca2+ sensor stromal interaction molecule 1 (STIM1) upon ER Ca2+ store‐depletion.
Fröhlich M +17 more
europepmc +2 more sources
Patch-clamp measurement of ICRAC and ORAI channel activity. [PDF]
, 2014 Depletion of internal Ca(2+) stores activates store-operated Ca(2+) channels. The most prominent members of this class of channels are Ca(2+) release-activated Ca(2+) (CRAC) channels, which are present in a variety of cell types including immune cells ...
Holzmann, Christian +5 more
core +1 more source
Students’ Perception on The Implementation of Orai Application In CLL Method in Teaching Speaking
JEELS (Journal of English Education and Linguistics Studies), 2022 This study aims to examine EFL learners’ perception toward the application of Orai App in CLL method in teaching speaking. The study employed likert-scale questionnaires to enable researchers to collect massive data.
Halimah +2 more
doaj +1 more source
Circulation Research, 2013 Three decades ago, Putney1 forwarded the idea of store-operated Ca2+ entry in mammalian cells. He rationalized that after the discharge of Ca2+ from an intracellular pool, an undefined signaling pathway would enhance extracellular Ca2+ influx and promote store refilling.
openaire +2 more sources