Results 21 to 30 of about 4,465 (176)

Store-independent modulation of Ca2+ entry through Orai by Septin 7

Nature Communications, 2016
Orai channels are well known to mediate store-operated calcium entry. Here authors show that in neurons of the Drosophilaflight circuit, Septin 7 acts as a negative regulator of Orai channels, surprisingly, by modulating store-independent calcium entry ...
Bipan Kumar Deb, Trayambak Pathak, Gaiti Hasan   +2 more
doaj   +1 more source

Store-operated calcium channels in skin

Frontiers in Physiology, 2022
The skin is a complex organ that acts as a protective layer against the external environment. It protects the internal tissues from harmful agents, dehydration, ultraviolet radiation and physical injury as well as conferring thermoregulatory control ...
Declan Manning, Declan Manning, Caroline Dart, Richard L Evans   +3 more
doaj   +1 more source

CRACking the Molecular Regulatory Mechanism of SOCE during Platelet Activation in Thrombo-Occlusive Diseases

Cells, 2022
Thrombo-occlusive diseases such as myocardial infarction, ischemic stroke and deep vein thrombosis with subsequent pulmonary embolism still represent a major health burden worldwide.
Patrick Münzer, Oliver Borst
doaj   +1 more source

The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells.

PLoS ONE, 2013
BackgroundThe influx of extracellular Ca(2+) into mast cells is critical for the FcεR1-dependent release of preformed granule-derived mediators and newly synthesised autacoids and cytokines.
Ian Ashmole, S Mark Duffy, Mark L Leyland, Peter Bradding   +3 more
doaj   +1 more source

Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells

Frontiers in Immunology, 2022
Mast cells (MCs) are tissue resident immune cells that play important roles in the pathogenesis of allergic disorders. These responses are mediated via the cross-linking of cell surface high affinity IgE receptor (FcϵRI) by antigen resulting in calcium ...
Shaswati Chaki, Ibrahim Alkanfari, Ibrahim Alkanfari, Saptarshi Roy, Aetas Amponnawarat, Aetas Amponnawarat, Yvonne Hui, Carole A. Oskeritzian, Hydar Ali   +8 more
doaj   +1 more source

Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?

Chinese Journal of Cancer, 2016
The stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) play pivotal roles in the modulation of Ca2+-regulated pathways from gene transcription to cell apoptosis ...
Jing Wen, Ying-Cheng Huang, Huan-Huan Xiu, Zhi-Ming Shan, Kang-Qing Xu   +4 more
doaj   +1 more source

TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes

Frontiers in Physiology, 2023
Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning, Richard Barrett-Jolley, Richard L. Evans, Caroline Dart   +3 more
doaj   +1 more source

ORAI Ca²⁺ Channels in Cancers and Therapeutic Interventions

Biomolecules
The ORAI proteins serve as crucial pore-forming subunits of calcium-release-activated calcium (CRAC) channels, pivotal in regulating downstream calcium-related signaling pathways.
Qian Zhang, Chen Wang, Lian He
doaj   +1 more source

Molecular understanding of calcium permeation through the open Orai channel.

PLoS Biology, 2019
The Orai channel is characterized by voltage independence, low conductance, and high Ca2+ selectivity and plays an important role in Ca2+ influx through the plasma membrane (PM).
Xiaofen Liu, Guangyan Wu, Yi Yu, Xiaozhe Chen, Renci Ji, Jing Lu, Xin Li, Xing Zhang, Xue Yang, Yuequan Shen   +9 more
doaj   +1 more source

Structures reveal opening of the store-operated calcium channel Orai

eLife, 2018
The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER).
Xiaowei Hou, Shana R Burstein, Stephen Barstow Long   +2 more
doaj   +1 more source