Results 11 to 20 of about 6,543 (175)
SOCE in the cardiomyocyte: the secret is in the chambers
Pflügers Archiv - European Journal of Physiology, 2021 Store-operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway that is present in virtually every cell type. Over the last two decades, many studies have implicated this non-voltage dependent Ca2+ entry pathway in cardiac physiology. The relevance of the SOCE pathway in cardiomyocytes is often questioned given the well-established
Paul Rosenberg +3 more
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SOCE as a regulator of neuronal activity
The Journal of Physiology, 2023 AbstractStore operated Ca2+ entry (SOCE) is a ubiquitous signalling module with established roles in the immune system, secretion and muscle development. Recent evidence supports a complex role for SOCE in the nervous system. In this review we present an update of the current knowledge on SOCE function in the brain with a focus on its role as a ...
Raphael Courjaret +2 more
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On the Connections between TRPM Channels and SOCE
Cells, 2022 Plasma membrane protein channels provide a passageway for ions to access the intracellular milieu. Rapid entry of calcium ions into cells is controlled mostly by ion channels, while Ca2+-ATPases and Ca2+ exchangers ensure that cytosolic Ca2+ levels ([Ca2+]cyt) are maintained at low (~100 nM) concentrations.
Guilherme H. Souza Bomfim +3 more
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Physiological and pathophysiological functions of SOCE in the immune system [PDF]
Frontiers in Bioscience, 2012 Calcium signals play a critical role in many cell-type specific effector functions during innate and adaptive immune responses. The predominant mechanism to raise intracellular (Ca²⁺) used by most immune cells is store-operated Ca²⁺ entry (SOCE), whereby the depletion of endoplasmic reticulum (ER) Ca²⁺ stores triggers the influx of extracellular Ca² ...
Patrick J, Shaw, Stefan, Feske
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The Molecular Basis for SOCE Regulation by SARAF [PDF]
Biophysical Journal, 2020 Author(s): Meshcheriakova, Anna; Kimberlin, Christopher; Palty, Raz; Karbat, Izhar; Minor, Daniel L; Reuveny ...
Meshcheriakova, Anna +5 more
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TRPC Channels in the SOCE Scenario
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well known that these channels are activated by stimuli that induce PIP2 hydrolysis.
Jose J. Lopez +5 more
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The role of STIM1 and SOCE in smooth muscle contractility [PDF]
Cell Calcium, 2017 Contraction is a central feature for skeletal, cardiac and smooth muscle; this unique feature is largely dependent on calcium (Ca2+) signaling and therefore maintenance of internal Ca2+ stores. Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane protein that functions as a Ca2+ sensor for the activation store-operated calcium channels
C H, Feldman +2 more
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International Journal of Cancer, 2015 Ca(2+) acts as a universal and versatile second messenger in the regulation of a myriad of biological processes, including cell proliferation, differentiation, migration and apoptosis. Store-operated Ca(2+) entry (SOCE) mediated by ORAI and the stromal interaction molecule (STIM) constitutes one of the major routes of calcium entry in nonexcitable ...
Xie, Jiansheng +4 more
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Saudi Pharmaceutical Journal, 2023 Store-operated calcium entry (SOCE) is an important pathway for calcium signaling that regulates calcium influx across the plasma membrane upon the depletion of calcium stores in the endoplasmic reticulum.
Abdullah S. Alhamed +11 more
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F1000Research, 2021 Background: Voluntary therapeutic interventions to reduce unwanted same-sex sexuality are collectively known as sexual orientation change efforts (SOCE). To date almost all evidence addressing the contested question whether SOCE is effective or safe has
D. Paul Sullins +2 more
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