Results 11 to 20 of about 9,094 (168)

Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes. [PDF]

PLoS ONE, 2019
AimsGlucocorticoid (GC) stimulation has been shown to increase cardiac contractility by elevated intracellular [Ca] but the sources for Ca entry are unclear. This study aims to determine the role of store-operated Ca entry (SOCE) for GC-mediated inotropy.
Michael Wester, Anton Heller, Michael Gruber, Lars S Maier, Christian Schach, Stefan Wagner   +5 more
doaj   +3 more sources

Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration.

PLoS ONE, 2014
Store-operated Ca(2+) entry (SOCE) is a major mechanism of Ca(2) (+) import from extracellular to intracellular space, involving detection of Ca(2+) store depletion in endoplasmic reticulum (ER) by stromal interaction molecule (STIM) proteins, which then
Masanari Umemura, Erdene Baljinnyam, Stefan Feske, Mariana S De Lorenzo, Lai-Hua Xie, Xianfeng Feng, Kayoko Oda, Ayako Makino, Takayuki Fujita, Utako Yokoyama, Mizuka Iwatsubo, Suzie Chen, James S Goydos, Yoshihiro Ishikawa, Kousaku Iwatsubo   +14 more
doaj   +2 more sources

Dental enamel cells express functional SOCE channels [PDF]

, 2015
Dental enamel formation requires large quantities of Ca(2+) yet the mechanisms mediating Ca(2+) dynamics in enamel cells are unclear. Store-operated Ca(2+) entry (SOCE) channels are important Ca(2+) influx mechanisms in many cells.
Srikanth, S, Nurbaeva, MK, Hubbard, MJ, Feske, S, Smith, CE, Lacruz, RS, Paine, ML, Concepcion, AR, Eckstein, M, Gwack, Y   +9 more
core   +3 more sources

Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells [PDF]

, 2020
The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal SOCE seem to underlie several diseases that notably include allergy, inflammation,

core   +2 more sources

Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers. [PDF]

Hum Immunol
Store-operated calcium entry (SOCE) plays a critical role in regulating intracellular calcium signaling and is essential for immune cell functions. SOCE blockade with the pyrazole derivative BTP2 has been explored as an anti-inflammatory strategy in ...
Stephanou A, Mantri M, Shankaranarayanan D, Li C, Lagman M, Xiang J, Pan C, Sun Y, Muthukumar T, Machaca K, De Vlaminck I, Suthanthiran M.   +11 more
europepmc   +3 more sources

Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries.

PLoS ONE, 2020
Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity.
Selina M Garcia, Lindsay M Herbert, Benjimen R Walker, Thomas C Resta, Nikki L Jernigan   +4 more
doaj   +1 more source

Efficacy and risk of sexual orientation change efforts: a retrospective analysis of 125 exposed men [version 1; peer review: 2 approved]

F1000Research, 2021
Background: Voluntary therapeutic interventions to reduce unwanted same-sex sexuality are collectively known as sexual orientation change efforts (SOCE).  To date almost all evidence addressing the contested question whether SOCE is effective or safe has 
D. Paul Sullins, Christopher H. Rosik, Paul Santero   +2 more
doaj   +1 more source

Antioxidants restore store‐operated Ca2+ entry in patient‐iPSC‐derived myotubes with tubular aggregate myopathy‐associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein

FASEB BioAdvances, 2023
Store‐operated Ca2+ entry (SOCE) is indispensable for intracellular Ca2+ homeostasis in skeletal muscle, and constitutive activation of SOCE causes tubular aggregate myopathy (TAM). To understand the pathogenesis of TAM, we induced pluripotent stem cells
Fusako Sakai‐Takemura, Fumiaki Saito, Ken'ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Kiichiro Matsumura, Shin'ichi Takeda, Yoshitsugu Aoki, Yuko Miyagoe‐Suzuki   +8 more
doaj   +1 more source

Celastrol inhibits store operated calcium entry and suppresses psoriasis

Frontiers in Pharmacology, 2023
Introduction: Psoriasis is an inflammatory autoimmune skin disease that is hard to cure and prone to relapse. Currently available global immunosuppressive agents for psoriasis may cause severe side effects, thus it is crucial to identify new therapeutic ...
Xiaoman Yuan, Bin Tang, Bin Tang, Yilan Chen, Lijuan Zhou, Jingwen Deng, Jingwen Deng, Lin Han, Lin Han, Yonggong Zhai, Yandong Zhou, Donald L. Gill, Chuanjian Lu, Chuanjian Lu, Youjun Wang, Youjun Wang   +15 more
doaj   +1 more source

Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart

Biology Open, 2020
Store-operated Ca2+ entry (SOCE) is an essential Ca2+ signaling mechanism present in most animal cells. SOCE refers to Ca2+ influx that is activated by depletion of sarco/endoplasmic reticulum (S/ER) Ca2+ stores.
Courtney E. Petersen, Matthew J. Wolf, Jeremy T. Smyth   +2 more
doaj   +1 more source