Results 31 to 40 of about 6,543 (175)

Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes

open access: yesCells, 2019
Whereas cardiac TRPC (transient receptor potential canonical) channels and the associated store-operated Ca2+ entry (SOCE) are abnormally elevated during cardiac hypertrophy and heart failure, the mechanism of this upregulation is not fully elucidated ...
Fiona Bartoli   +6 more
doaj   +1 more source

A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. [PDF]

open access: yesPLoS ONE, 2010
Store-operated Ca(2+) entry (SOCE) channels are the main pathway of Ca(2+) entry in non-excitable cells such as neural progenitor cells (NPCs). However, the role of SOCE channels has not been defined in the neuronal differentiation from NPCs.
Hye Young Shin   +9 more
doaj   +1 more source

Store-operated calcium entry and the localisation of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells

open access: yesFrontiers in Physiology, 2015
In many nonexcitable and excitable cells, store-operated calcium entry (SOCE) represents an additional pathway for calcium entry upon Ca2+ store depletion.
Jie eLiu   +4 more
doaj   +1 more source

Inhibition of store-operated calcium entry attenuates MPP(+)-induced oxidative stress via preservation of mitochondrial function in PC12 cells: involvement of Homer1a. [PDF]

open access: yesPLoS ONE, 2013
The process of store-operated calcium entry (SOCE), whereby the release of intracellular Ca(2+) from endoplasmic reticulum (ER) activates Ca(2+) influx channels in the plasma membrane, has been demonstrated to impact a diverse range of cell functions. In
Xia Li   +4 more
doaj   +1 more source

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis

open access: yesCells, 2021
Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
doaj   +1 more source

Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical Neurons

open access: yesFrontiers in Cellular Neuroscience, 2017
Store-operated calcium entry (SOCE) is a Calcium (Ca2+) influx pathway activated by depletion of intracellular stores that occurs in eukaryotic cells. In neurons, the presence and functions of SOCE are still in question.
Paloma González-Sánchez   +9 more
doaj   +1 more source

Efficacy and risk of sexual orientation change efforts: a retrospective analysis of 125 exposed men [version 2; peer review: 2 approved]

open access: yesF1000Research, 2021
Background: Voluntary therapeutic interventions to reduce unwanted same-sex sexuality are collectively known as sexual orientation change efforts (SOCE).
D. Paul Sullins   +2 more
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

open access: yesAdvanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu   +4 more
wiley   +1 more source

STIM1-Orai1 interaction mediated calcium influx activation contributes to cardiac contractility of insulin-resistant rats

open access: yesBMC Cardiovascular Disorders, 2022
Purpose Metabolic syndrome (MetS) became a tremendous public health burden in the last decades. Store-operated calcium entry (SOCE) is a unique mechanism that causes a calcium influx, which is triggered by calcium store depletion.
Aysegul Durak   +6 more
doaj   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

open access: yesArthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel   +12 more
wiley   +1 more source

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