Results 41 to 50 of about 9,094 (168)
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
BMC Cardiovascular Disorders, 2022 Purpose Metabolic syndrome (MetS) became a tremendous public health burden in the last decades. Store-operated calcium entry (SOCE) is a unique mechanism that causes a calcium influx, which is triggered by calcium store depletion.
Aysegul Durak +6 more
doaj +1 more source
Oral Diseases, EarlyView.ABSTRACT Objective Pistacia lentiscus L. tree is known for its aromatic mastic gum containing terpenes α‐pinene and β‐myrcene, and has been applied as a traditional remedy in oral care for centuries. Previously, intranasal exposure to mastic resin volatiles increased salivary flow in healthy and dry‐mouth individuals. This study assessed the biological
Wiktoria Potocka +4 more
wiley +1 more source
The role of the Sigma1 receptor (s1R) in Store-operated calcium entry (SOCE) microdomains
, 2020 The Sigma1 receptor (s1R) is an endoplasmic reticulum (ER) chaperone targeted to mitochondrion associated ER membranes (MAMs). The upregulation of s1R is associated with various cancers, whereas the decreased expression and mutant forms of s1R are ...
Petra Visic (16281011)
core +1 more source
Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling
Oral Diseases, EarlyView.ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung +4 more
wiley +1 more source
A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling [PDF]
, 2021 Alternative splicing is a potent modifier of protein function. Stro mal interaction molecule 1 (Stim1) is the essential activator of store-operated Ca2+ entry (SOCE) triggering activation of transcrip tion factors. Here, we characterize Stim1A, a splice
Schroda, Michael +14 more
core +5 more sources
Journal of Biomedical Science, 2020 Background Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis.
Ho-Kai Huang +7 more
doaj +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
, 2017 (A and B) Control and HBx-expressing primary rat hepatocytes were loaded with 5 μM Fura-4F and treated with 2 μM TG in Ca2+-free buffer for 10 min. 1 mM CaCl2 (Ca2+) was then added back to the imaging buffer, and Fura-4F ratios were recorded during the ...
Michael J. Bouchard (824878) +4 more
core +1 more source
Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow
The Journal of Physiology, EarlyView.Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley +1 more source