Results 61 to 70 of about 6,543 (175)

Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.

PLoS ONE, 2014
BackgroundAn increase in the frequency of circulating endothelial colony forming cells (ECFCs), the only subset of endothelial progenitor cells (EPCs) truly belonging to the endothelial phenotype, occurs in patients affected by primary myelofibrosis (PMF)
Silvia Dragoni, Umberto Laforenza, Elisa Bonetti, Marta Reforgiato, Valentina Poletto, Francesco Lodola, Cinzia Bottino, Daniele Guido, Alessandra Rappa, Sumedha Pareek, Mario Tomasello, Maria Rosa Guarrera, Maria Pia Cinelli, Adele Aronica, Germano Guerra, Giovanni Barosi, Franco Tanzi, Vittorio Rosti, Francesco Moccia   +18 more
doaj   +1 more source

Altered TRPM3‐Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post‐COVID‐19 Condition Patients

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Chandi Tabeth Magawa, Natalie Eaton‐Fitch, Katsuhiko Muraki, Sonya Marshall‐Gradisnik   +3 more
wiley   +1 more source

On the Role of Store-Operated Calcium Entry in Acute and Chronic Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2018
In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from ...
Agnese Secondo, Giacinto Bagetta, Diana Amantea   +2 more
doaj   +1 more source

Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease

Frontiers in Cell and Developmental Biology, 2020
Huntington's disease (HD) is a progressive neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric problems. It is caused by a polyglutamine expansion in the huntingtin protein that leads to striatal degeneration via the ...
Magdalena Czeredys
doaj   +1 more source

The Role of Piezo Ion Channels in Pulmonary Hypertension

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary hypertension (PH) is a chronic and devastating disease that currently lacks effective therapies, often ultimately requiring lung transplantation. Pulmonary vascular cells are subjected to various mechanical forces, which contribute to cardiovascular remodeling in PH.
Kewei Chen, Lingchen Li, Yajie Huang, Lixia Ye, Yu Wang, Ziming Zhang, Chengcheng Hang, Qiqi Li, Qianyun Cao, Lizhong Du   +9 more
wiley   +1 more source

Rationale Formulierung von Elektrolyten auf Ether‐Lacton‐Basis für sichere und nachhaltige nickelreiche Lithium‐Ionen‐Batterien

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
Diese Studie berichtet über die Formulierung neuartiger Elektrolyte zur Verbesserung von Sicherheit, Nachhaltigkeit und Kompatibilität mit nickelreichen Kathoden durch den Einsatz eines biobasierten Lösungsmittels (γ‐Valerolacton, GVL) sowie eines sicheren und stabilen Hilfslösungsmittels (Diethylenglycolbutylethylether, DEGBEE).
Juan Luis Gómez‐Urbano, Markus Binder, Endy Nugroho Dwiputra, Thomas Diemant, Dominic Bresser, Adriano Pierini, Andrea Cioffi, Enrico Bodo, Sergio Brutti, Matjaž Koželj, Tom Gouveia, Emma Bremond, Alix Ladam, Sébastien Fantini, Susan Sananes‐Israel, Imanol Landa‐Medrano, Iratxe de Meatza, Andrea Balducci   +17 more
wiley   +1 more source

Vulnerability of Store-Operated Calcium Entry to Inhibitors and Microenvironment in Cells of Different Breast Cancer Subtypes

Life
The incidence and development of cancer are highly dependent on pathological disturbances in calcium homeostasis of the cell. One of the major pathways for calcium entry is store-operated calcium entry (SOCE), which functions in virtually all cell types.
Anton Y. Skopin, Lubov N. Glushankova, Konstantin O. Gusev, Elena V. Kaznacheyeva   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source