Results 71 to 80 of about 9,094 (168)

Implication de la protéine MURC/Cavin4 dans la régulation du SOCE chez les cardiomyocytes [PDF]

, 2019
Dans le cœur, le maintien de l’homéostasie du Ca2+ est crucial pour assurer le métabolisme des cardiomyocytes. Des mécanismes cellulaires tels le SOCE (store-operated calcium entry) permettent de réguler finement la concentration du Ca2+ dans ce type ...
Malette, Julien
core   +1 more source

The Mechanobiology of Adipocyte Hypertrophy: Cytoskeletal Remodelling as a Driver of Insulin Resistance in Obesity

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Adipocyte hypertrophy poses an important mechanical challenge—adipocytes can increase in volume up to a thousand‐fold while still maintaining their structural integrity. Although lipid metabolism is well studied, little is known about the cytoskeletal adaptations that are required to accommodate this expansion and the resulting pathological ...
Dhakshmi Sasankan, Renu Mohan
wiley   +1 more source

SOCE inhibitory activity (IC₅₀ ± SE) of the SOCE inhibitors studied, compared to their reported IC₅₀ values.

SOCE inhibitory activity (IC50 ± SE) of the SOCE inhibitors studied, compared to their reported IC50 values.
David J. Beech (9248272), Heba Shawer (4977494), Nurasyikin Hamzah (17833801), Karen E. Hemmings (17833792), Katherine Norman (17833789), Marc A. Bailey (12042573), Emily M. Woodhouse (17833807), Rajendra Gosain (17833804), Hollie L. Appleby (17833795), Richard Foster (4003289), Alan J. Burnett (17833798)   +10 more
core   +1 more source

Deletion of RyR2 reduces SOCE: Reduced time of exposure to 2-APB.

, 2023
Representative experiments showing activation of SOCE in control INS-1 cells A), in RyR2KO cells B), and in IRBITKO cells C) with reduced time of exposure to 2-APB prior to re-introduction of Ca2+. ER Ca2+ stores were depleted with injection thapsigargin
Shiqi Tang (10908109), Gregory H. Hockerman (1976350), Kyle E. Harvey (4375987), Emily K. LaVigne (15411854), Evan P. S. Pratt (7305542)   +4 more
core   +1 more source

Vulnerability of Store-Operated Calcium Entry to Inhibitors and Microenvironment in Cells of Different Breast Cancer Subtypes

Life
The incidence and development of cancer are highly dependent on pathological disturbances in calcium homeostasis of the cell. One of the major pathways for calcium entry is store-operated calcium entry (SOCE), which functions in virtually all cell types.
Anton Y. Skopin, Lubov N. Glushankova, Konstantin O. Gusev, Elena V. Kaznacheyeva   +3 more
doaj   +1 more source

Ryanodine Receptor 1 Is Dispensable for CD4+ T‐Cell Differentiation and Effector Function in Intestinal Inflammation Models

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Ryr1 deletion reduces Ca2+ microdomains and delays global Ca2+ signaling in naïve CD4+ T cells but does not impair their activation, proliferation, or differentiation in vitro. Despite altered Ca2+ signaling, Ryr1 expression in CD4+ T cells was dispensable for their pathogenicity in murine models of intestinal inflammation.
Sogol Dostiar Tabrizi, Mikolaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn‐Phillip Diercks, Nicola Gagliani, Dmitri Lodygin, Alexander Flügel, Andreas H. Guse, Hans‐Willi Mittrücker, Samuel Huber   +14 more
wiley   +1 more source

The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and Store-Operated Calcium Entry (SOCE) [PDF]

, 2014
Store-Operated Calcium Entry (SOCE) is the predominant Ca2+ entry mechanism in nonexcitable cells and controls a variety of physiological and pathological processes. Although significant progress has been made to identify the components required for SOCE,
Ulivieri, C., Marruganti, S., Randazzo, D., Giurisato, E., Gamberucci, A., Giacomello, E., Rossi, E., Sorrentino, V., Giurisato, E, GIACOMELLO, EMILIANA   +9 more
core   +1 more source

Postbiotics of Lacticaseibacillus paracasei CECT 9610 and Lactiplantibacillus plantarum CECT 9608 attenuates store‐operated calcium entry and FAK phosphorylation in colorectal cancer cells

Molecular Oncology
Store‐operated Ca2+ entry (SOCE) is a major mechanism for Ca2+ influx in colorectal cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca2+ stores, is mediated by the endoplasmic reticulum Ca2+ sensors of the stromal ...
Alvaro Macias‐Diaz, Jose J. Lopez, Maria Bravo, Isaac Jardín, Waldo Luis Garcia‐Jimenez, Francisco J. Blanco‐Blanco, Rosario Cerrato, Juan A. Rosado   +7 more
doaj   +1 more source

High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release-Activated Ca2+ Channels in Rat Odontoblasts

Frontiers in Physiology, 2018
Odontoblasts play a crucial role in dentin formation and sensory transduction following the application of stimuli to the dentin surface. Various exogenous and endogenous stimuli elicit an increase in the intracellular free calcium concentration ([Ca2+]i)
Maki Kimura, Koichi Nishi, Asuka Higashikawa, Sadao Ohyama, Sadao Ohyama, Kaoru Sakurai, Masakazu Tazaki, Yoshiyuki Shibukawa   +7 more
doaj   +1 more source

AMPA receptors are involved in store-operated calcium entry and interact with STIM proteins in rat primary cortical neurons

Frontiers in Cellular Neuroscience, 2016
The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 STIM1 and
Joanna Gruszczynska-Biegala, Maria Julia Sladowska, Jacek Kuznicki   +2 more
doaj   +1 more source