Results 71 to 80 of about 6,543 (175)

Postbiotics of Lacticaseibacillus paracasei CECT 9610 and Lactiplantibacillus plantarum CECT 9608 attenuates store‐operated calcium entry and FAK phosphorylation in colorectal cancer cells

Molecular Oncology
Store‐operated Ca2+ entry (SOCE) is a major mechanism for Ca2+ influx in colorectal cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca2+ stores, is mediated by the endoplasmic reticulum Ca2+ sensors of the stromal ...
Alvaro Macias‐Diaz, Jose J. Lopez, Maria Bravo, Isaac Jardín, Waldo Luis Garcia‐Jimenez, Francisco J. Blanco‐Blanco, Rosario Cerrato, Juan A. Rosado   +7 more
doaj   +1 more source

High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release-Activated Ca2+ Channels in Rat Odontoblasts

Frontiers in Physiology, 2018
Odontoblasts play a crucial role in dentin formation and sensory transduction following the application of stimuli to the dentin surface. Various exogenous and endogenous stimuli elicit an increase in the intracellular free calcium concentration ([Ca2+]i)
Maki Kimura, Koichi Nishi, Asuka Higashikawa, Sadao Ohyama, Sadao Ohyama, Kaoru Sakurai, Masakazu Tazaki, Yoshiyuki Shibukawa   +7 more
doaj   +1 more source

AMPA receptors are involved in store-operated calcium entry and interact with STIM proteins in rat primary cortical neurons

Frontiers in Cellular Neuroscience, 2016
The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 STIM1 and
Joanna Gruszczynska-Biegala, Maria Julia Sladowska, Jacek Kuznicki   +2 more
doaj   +1 more source

Lithium Sensitivity of Store Operated Ca2+ Entry and Survival of Fibroblasts Isolated from Chorea-Acanthocytosis Patients

Cellular Physiology and Biochemistry, 2017
Background: The widely expressed protein chorein fosters activation of the phosphoinositide 3 kinase (PI3K) pathway thus supporting cell survival. Loss of function mutations of the chorein encoding gene VPS13A (vacuolar protein sorting-associated protein
Lisann Pelzl, Bhaeldin Elsir, Itishri Sahu, Rosi Bissinger, Yogesh Singh, Basma Sukkar, Sabina Honisch, Ludger Schoels, Mohamed Jemaà, Elisabeth Lang, Alexander Storch, Andreas Hermann, Christos Stournaras, Florian Lang   +13 more
doaj   +1 more source

Spontaneous Ca2+ Influx in Drosophila Pupal Neurons Is Modulated by IP3-Receptor Function and Influences Maturation of the Flight Circuit

Frontiers in Molecular Neuroscience, 2017
Inositol 1,4,5-trisphosphate receptors (IP3R) are Ca2+ channels on the neuronal endoplasmic reticulum (ER) membrane. They are gated by IP3, produced upon external stimulation and activation of G protein-coupled receptors on the plasma membrane (PM).
Sumita Chakraborty, Gaiti Hasan
doaj   +1 more source

ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai

The Journal of Physiology, 2012
Abstract  Store‐operated Ca2+ entry (SOCE) is a widespread mechanism in cells to raise cytosolic Ca2+ and to refill Ca2+ stores. T cells critically rely on SOCE mediated by stromal interaction molecules (STIM) and Orai molecules for their activation and regulation of gene transcription; cells such as muscle cells, neurons or melanocytes probably ...
Bogeski, Ivan, Kilch, Tatiana, Niemeyer, Barbara A.   +2 more
openaire   +4 more sources

STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma

Genes and Diseases
Dysregulated calcium (Ca2+) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for Ca2+ influx is through stromal interaction molecule 1 ...
Ran Ren, Yu Chen, Yu Zhou, Luyao Shen, Yang Chen, Juan Lei, Jingchun Wang, Xudong Liu, Nan Zhang, Dongqin Zhou, Huakan Zhao, Yongsheng Li   +11 more
doaj   +1 more source

Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca2+ entry in HEK293 cells.

PLoS ONE
Calcium (Ca2+) is a key second messenger in eukaryotes, with store-operated Ca2+ entry (SOCE) being the main source of Ca2+ influx into non-excitable cells. ORAI1 is a highly Ca2+-selective plasma membrane channel that encodes SOCE.
Katherine Norman, Karen E Hemmings, Heba Shawer, Hollie L Appleby, Alan J Burnett, Nurasyikin Hamzah, Rajendra Gosain, Emily M Woodhouse, David J Beech, Richard Foster, Marc A Bailey   +10 more
doaj   +1 more source

Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases

Channels
Store-operated calcium entry (SOCE) mediated by STIM and Orai proteins is a fundamental Ca2+ influx mechanism that critically regulates intracellular calcium homeostasis and participates in cardiovascular pathophysiology.
Xin Liao, Chenglin Pan, Xueqing Guo, Jun Cheng   +3 more
doaj   +1 more source

Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells

, 2020
The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal SOCE seem to underlie several diseases that notably include allergy, inflammation, acute pancreatitis and cancer.
openaire   +2 more sources