Results 81 to 90 of about 6,543 (175)

Factors affecting SOCE activation in mammalian skeletal muscle fibers

The Journal of Physiological Sciences, 2009
Enzymatically dissociated mouse FDB muscle fibers, loaded with Fura-2 AM, were used to study the effect of mitochondrial uncoupling on the capacitative Ca(2+) entry, SOCE. Sarcoplasmic reticulum (SR) Ca(2+) stores were depleted by repetitive exposures to high K(+) or 4-chloro-m-Cresol (4-CmC) in the absence of extracellular Ca(2+).
Pura, Bolaños, Alis, Guillén, Reinaldo, DiPolo, Carlo, Caputo   +3 more
openaire   +2 more sources

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes

Frontiers in Physiology, 2018
Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen, Hairuo Wen, Zhenghang Zhao, Nadezhda Fefelova, Lai-Hua Xie   +4 more
doaj   +1 more source

Store-operated Ca2+ entry plays a role in HMGB1-induced vascular endothelial cell hyperpermeability.

PLoS ONE, 2015
AimsEndothelial dysfunction, including increased endothelial permeability, is considered an early marker for atherosclerosis. High-mobility group box 1 protein (HMGB1) and extracellular Ca2+ entry, primarily mediated through store-operated Ca2+ entry ...
Mengchen Zou, Hangming Dong, Xiaojing Meng, Chunqing Cai, Chenzhong Li, Shaoxi Cai, Yaoming Xue   +6 more
doaj   +1 more source

Discovery and development of small molecules targeting IDO1 and SOCE

, 2021
My PhD thesis is focused on two main projects: the discovery of Store-Operated Calcium Entry (SOCE) modulators and the development of indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors. SOCE is a specialized form of calcium influx across the plasma membrane that is induced by the depletion of this ion in the endoplasmic reticulum.
openaire   +3 more sources

NODES_Inndiana_D14_RM4_Biphenyl Amides as Dual-Targeting SOCE/DHODH Inhibitors

The patent application titled “Biphenyl Amides as Dual-Targeting SOCE/DHODH Inhibitors” (No. 102024000024384) describes novel biphenyl amides that can simultaneously modulate Store-Operated Calcium Entry (SOCE) and human dihydroorotate dehydrogenase (hDHODH) for the treatment of autoimmune, inflammatory, and chronic degenerative diseases, as well as ...
Di Martino, Rita Maria Concetta, PIRALI, Tracey   +1 more
openaire   +2 more sources

Functional model for amelogenesis: polarization and pH sensitivity of calcium uptake in ameloblast-derived HAT-7 cells. [PDF]

Calcif Tissue Int
Kádár K, Földes A, Rácz R, Van-Weert S, Soós Á, Bruce J, Steward MC, DenBesten P, Varga G, Zsembery Á.   +9 more
europepmc   +1 more source

Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm. [PDF]

Biomolecules
Wang YQ, Pan M, Lin YC, Zheng SY, Chen QY, Gui LX, Lin MJ, Lin DC.   +7 more
europepmc   +1 more source

Inhibition of TRPC6 channel suppresses bladder cancer proliferation by disrupting store-operated calcium entry. [PDF]

Sci Rep
Zha J, Guo X, Liao W, Wu P, Wu Y, Guo Y, Yang W, Gao L.   +7 more
europepmc   +1 more source

CRAC channels as targets for immunotherapy. [PDF]

Curr Opin Immunol
Stauderman K, Hebbar S, Feske S.
europepmc   +1 more source

Unraveling new functions of the Ca2+ sensor STIM1 in cell signaling. [PDF]

Biochem Soc Trans
Sanchez-Lopez I, Orantos-Aguilera Y, Lopez-Guerrero AM, Pozo-Guisado E, Martin-Romero FJ.   +4 more
europepmc   +1 more source