Results 81 to 90 of about 9,094 (168)

Lithium Sensitivity of Store Operated Ca2+ Entry and Survival of Fibroblasts Isolated from Chorea-Acanthocytosis Patients

Cellular Physiology and Biochemistry, 2017
Background: The widely expressed protein chorein fosters activation of the phosphoinositide 3 kinase (PI3K) pathway thus supporting cell survival. Loss of function mutations of the chorein encoding gene VPS13A (vacuolar protein sorting-associated protein
Lisann Pelzl, Bhaeldin Elsir, Itishri Sahu, Rosi Bissinger, Yogesh Singh, Basma Sukkar, Sabina Honisch, Ludger Schoels, Mohamed Jemaà, Elisabeth Lang, Alexander Storch, Andreas Hermann, Christos Stournaras, Florian Lang   +13 more
doaj   +1 more source

SOCE is required for HBV replication.

, 2017
(A and B) Primary rat hepatocytes were loaded with 5 μM Fura-4F and treated with 2 μM TG in Ca2+-free buffer, followed by treatment with DMSO or the SOCE inhibitor 50 μM APB (A) or 100 nM La3+ (B) before the addition of 1 mM CaCl2 (Ca2+).
Michael J. Bouchard (824878), R. Jason Lamontagne (3712525), Laura F. Steel (228812), Jessica C. Casciano (3712522), Nicholas J. Duchemin (3712528)   +4 more
core   +1 more source

Spontaneous Ca2+ Influx in Drosophila Pupal Neurons Is Modulated by IP3-Receptor Function and Influences Maturation of the Flight Circuit

Frontiers in Molecular Neuroscience, 2017
Inositol 1,4,5-trisphosphate receptors (IP3R) are Ca2+ channels on the neuronal endoplasmic reticulum (ER) membrane. They are gated by IP3, produced upon external stimulation and activation of G protein-coupled receptors on the plasma membrane (PM).
Sumita Chakraborty, Gaiti Hasan
doaj   +1 more source

Purinergic Activation of Store-Operated Calcium Entry (SOCE) Regulates Cell Migration in Metastatic Ovarian Cancer Cells

, 2023
Store-operated calcium entry (SOCE) is an important process in calcium signaling. Its role in physiological and pathological events is well recognized.
Esperanza Mata-Martínez, Adriana Gonzalez-Gallardo, Mauricio Díaz-Muñoz, Francisco G. Vázquez-Cuevas   +3 more
core   +1 more source

SOCE increases phosphorylation of ERK in melanoma.

, 2014
(A) Densitometric analyses (bar graph) of western blots show that thapsigargin increased phosphorylation of ERK1/2 in metastatic melanoma cell lines.
Lai-Hua Xie (61988), Erdene Baljinnyam (525855), Yoshihiro Ishikawa (324232), Kousaku Iwatsubo (525861), Utako Yokoyama (324208), Takayuki Fujita (324224), Ayako Makino (525859), Xianfeng Feng (525857), Stefan Feske (236350), Kayoko Oda (525858), Mizuka Iwatsubo (525860), Masanari Umemura (525854), Suzie Chen (438020), James S. Goydos (303127), Mariana S. De Lorenzo (525856)   +14 more
core   +1 more source

STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma

Genes and Diseases
Dysregulated calcium (Ca2+) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for Ca2+ influx is through stromal interaction molecule 1 ...
Ran Ren, Yu Chen, Yu Zhou, Luyao Shen, Yang Chen, Juan Lei, Jingchun Wang, Xudong Liu, Nan Zhang, Dongqin Zhou, Huakan Zhao, Yongsheng Li   +11 more
doaj   +1 more source

Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca2+ entry in HEK293 cells.

PLoS ONE
Calcium (Ca2+) is a key second messenger in eukaryotes, with store-operated Ca2+ entry (SOCE) being the main source of Ca2+ influx into non-excitable cells. ORAI1 is a highly Ca2+-selective plasma membrane channel that encodes SOCE.
Katherine Norman, Karen E Hemmings, Heba Shawer, Hollie L Appleby, Alan J Burnett, Nurasyikin Hamzah, Rajendra Gosain, Emily M Woodhouse, David J Beech, Richard Foster, Marc A Bailey   +10 more
doaj   +1 more source

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes

Frontiers in Physiology, 2018
Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen, Hairuo Wen, Zhenghang Zhao, Nadezhda Fefelova, Lai-Hua Xie   +4 more
doaj   +1 more source

NSCLC cells display SOCE.

, 2013
Thapsigargin (TG, 1 µM) applied to NCI-H23 cells (A) or NCI-H460 (B) in 0 mM Ca2+ solution (0Ca) induced an increase of F350/F380 fluorescence. Re-introduction of 5 mM Ca2+ solution (5Ca) induced stable increase in Ca2+ signal, a characteristic of SOCE ...
Nazim Benzerdjerb (458394), Ahmed Ahidouch (49130), Henri Sevestre (49129), Anne-Sophie Ay (458393), Halima Ouadid-Ahidouch (49131)   +4 more
core   +1 more source

Store-operated Ca2+ entry plays a role in HMGB1-induced vascular endothelial cell hyperpermeability.

PLoS ONE, 2015
AimsEndothelial dysfunction, including increased endothelial permeability, is considered an early marker for atherosclerosis. High-mobility group box 1 protein (HMGB1) and extracellular Ca2+ entry, primarily mediated through store-operated Ca2+ entry ...
Mengchen Zou, Hangming Dong, Xiaojing Meng, Chunqing Cai, Chenzhong Li, Shaoxi Cai, Yaoming Xue   +6 more
doaj   +1 more source