Results 51 to 60 of about 9,094 (168)

CLCA2 enhances ER calcium stores and SOCE.

, 2018
Calcium imaging studies using HEK293 cells loaded with calcium fluorophore Fluo-4. (A) Cells were treated with 2 micromolar ionomycin in the absence of extracellular calcium to allow ER depletion, then calcium was added to allow SOCE.
Aarushi Sharma (5216615), Grace Ramena (2549773), Louis Premkumar (5216612), Yufang Yin (2549770), Randolph C. Elble (502366)   +4 more
core   +1 more source

A potential new approach for treating systemic sclerosis: Dedifferentiation of SSc fibroblasts and change in the microenvironment by blocking store-operated Ca2+ entry.

PLoS ONE, 2019
Transforming growth factor-β (TGF-β) is an important target for treating systemic sclerosis (SSc). However, our study revealed three levels of TGF-β1 expression in SSc patients, indicating that inhibiting TGF-β is not sufficient to treat SSc.
Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Chee-Yin Chai, Chia-Jung Yen, Chu-Huang Chen, Jian-He Lu, Hsin-Su Yu, Tohru Yoshioka   +8 more
doaj   +1 more source

Gastrodin Inhibits Store-Operated Ca2+ Entry and Alleviates Cardiac Hypertrophy

Frontiers in Pharmacology, 2017
Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety issues.
Xiaoqiang Yao, Xiaoqiang Yao, Changbo Zheng, Changbo Zheng, Chun-Yin Lo, Chun-Yin Lo, Zhaoyue Meng, Zhaoyue Meng, Zhaoyue Meng, Zhichao Li, Zhichao Li, Mingkui Zhong, Peng Zhang, Jun Lu, Jun Lu, Zhaoxiang Yang, Fuman Yan, Yunting Zhang, Yu Huang   +18 more
doaj   +1 more source

Pathological Mechanism of a Constitutively Active Form of Stromal Interaction Molecule 1 in Skeletal Muscle

Biomolecules, 2021
Stromal interaction molecule 1 (STIM1) is the main protein that, along with Orai1, mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. Abnormal SOCE due to mutations in STIM1 is one of the causes of human skeletal muscle diseases.
Ji Hee Park, Seung Yeon Jeong, Jun Hee Choi, Eun Hui Lee   +3 more
doaj   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

SOCE and STIM1 signaling in the heart: Timing and location matter

, 2018
Store operated Ca(2+) entry (SOCE) is an ancient and ubiquitous Ca(2+) signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to striated muscle was solidified with
Paul Rosenberg, Danielle Katz, Victoria Bryson, Katz, Danielle, Rosenberg, Paul, Bryson, Victoria   +5 more
core   +1 more source

Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease [PDF]

, 2019
Store-operated Ca2+ entry (SOCE), a major Ca2+ signaling mechanism in non-myocyte cells, has recently emerged as a component of Ca2+ signaling in cardiac myocytes. Though it has been reported to play a role in cardiac arrhythmias and to be upregulated in
Radwanski, P. B., Volpe P., Priori S., Veeraraghavan R., Weisleder N., Belevych, A. E., Liu, B., Bonilla I. M., Stepanov A., Radwanski P. B., Stepanov, A., Mezache, L., Bodnar T., Gyorke, S., Baine S., Bodnar, T., Veeraraghavan, R., Carnes C. A., Baine, S., Priori, S., Sakuta G., Sakuta, G., Weisleder, N., Liu B., Volpe, P., Mezache L., Gyorke S., Bonilla, I. M., Carnes, C. A., Belevych A. E.   +29 more
core   +1 more source

Blocking Store-Operated Ca²⁺ Entry to Protect HL-1 Cardiomyocytes from Epirubicin-Induced Cardiotoxicity

Cells, 2023
Epirubicin (EPI) is one of the most widely used anthracycline chemotherapy drugs, yet its cardiotoxicity severely limits its clinical application.
Xian Liu, Yan Chang, Sangyong Choi, Chuanxi Cai, Xiaoli Zhang, Zui Pan   +5 more
doaj   +1 more source

Using Tower‐Based Observational Networks to Assess the Impact of COVID‐19 Lockdowns on Greenhouse Gas Emissions in Six North American Cities

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 17, 16 September 2026.
Abstract The onset of the COVID‐19 pandemic in North America and the lockdowns that followed in March 2020 brought forth a rapid change to societal functions disrupting many aspects of normal life, including the greenhouse gas emissions associated with them.
Z. R. Barkley, K. J. Davis, N. L. Miles, S. Baray, F. Vogel, J. Kim, R. F. Weiss, J. C. Lin, K. R. Gurney, J. C. Turnbull, H. A. Young   +10 more
wiley   +1 more source