Results 51 to 60 of about 6,543 (175)

Gastrodin Inhibits Store-Operated Ca2+ Entry and Alleviates Cardiac Hypertrophy

Frontiers in Pharmacology, 2017
Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety issues.
Xiaoqiang Yao, Xiaoqiang Yao, Changbo Zheng, Changbo Zheng, Chun-Yin Lo, Chun-Yin Lo, Zhaoyue Meng, Zhaoyue Meng, Zhaoyue Meng, Zhichao Li, Zhichao Li, Mingkui Zhong, Peng Zhang, Jun Lu, Jun Lu, Zhaoxiang Yang, Fuman Yan, Yunting Zhang, Yu Huang   +18 more
doaj   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes.

PLoS ONE, 2019
AimsGlucocorticoid (GC) stimulation has been shown to increase cardiac contractility by elevated intracellular [Ca] but the sources for Ca entry are unclear. This study aims to determine the role of store-operated Ca entry (SOCE) for GC-mediated inotropy.
Michael Wester, Anton Heller, Michael Gruber, Lars S Maier, Christian Schach, Stefan Wagner   +5 more
doaj   +1 more source

Blocking Store-Operated Ca²⁺ Entry to Protect HL-1 Cardiomyocytes from Epirubicin-Induced Cardiotoxicity

Cells, 2023
Epirubicin (EPI) is one of the most widely used anthracycline chemotherapy drugs, yet its cardiotoxicity severely limits its clinical application.
Xian Liu, Yan Chang, Sangyong Choi, Chuanxi Cai, Xiaoli Zhang, Zui Pan   +5 more
doaj   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Regulation of STIM1 and SOCE by the Ubiquitin-Proteasome System (UPS)

PLoS ONE, 2010
The ubiquitin proteasome system (UPS) mediates the majority of protein degradation in eukaryotic cells. The UPS has recently emerged as a key degradation pathway involved in synapse development and function. In order to better understand the function of the UPS at synapses we utilized a genetic and proteomic approach to isolate and identify novel ...
Jeffrey M Keil, Zhouxin Shen, Steven P Briggs, Gentry N Patrick   +3 more
openaire   +4 more sources

Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. [PDF]

PLoS ONE, 2012
BACKGROUND:Endothelial progenitor cells (EPCs) may be recruited from bone marrow to sustain tumor vascularisation and promote the metastatic switch. Understanding the molecular mechanisms driving EPC proliferation and tubulogenesis could outline novel ...
Francesco Lodola, Umberto Laforenza, Elisa Bonetti, Dmitry Lim, Silvia Dragoni, Cinzia Bottino, Hwei Ling Ong, Germano Guerra, Carlo Ganini, Margherita Massa, Mariangela Manzoni, Indu S Ambudkar, Armando A Genazzani, Vittorio Rosti, Paolo Pedrazzoli, Franco Tanzi, Francesco Moccia, Camillo Porta   +17 more
doaj   +1 more source

Prosociality: Against Consequentialism and Towards Relationality

Journal for the Theory of Social Behaviour, Volume 56, Issue 3, September 2026.
ABSTRACT Prosocial behaviour is a topic of concern within sociology and the social sciences more broadly. Though defined in various ways, the dominant theme of existing definitions of prosociality centres the causal power of an act in producing real or intended benefits for some other agents, at a cost to the agent that performed the act.
Maurice Bokanga
wiley   +1 more source

How Does Cultural and Colonial Heritage Affect Optimal Branding Strategies? Evidence From the Rice Sector in Senegal

Agribusiness, Volume 42, Issue 3, Page 1288-1300, Summer 2026.
ABSTRACT Africa's cultural and colonial heritage has profoundly segmented rice markets. Whereas in ancient centers of rice domestication, consumers maintained preferences for local rice consistent with their cultural heritage, preferences have shifted toward imported Asian rice in coastal areas around seaports, due to prior exposure to colonial import ...
Kofi Britwum, Matty Demont
wiley   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1338-1352, July 2026.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source