Novel fluorescent reporters for the Stromal Interaction Molecule 1
The FASEB Journal, 2013 The stromal interaction molecule 1 (Stim1) is a Ca 2+ sensor in the endoplasmic/sarcoplasmic reticulum whose Ca 2+ sensing triggers its dimerization and subsequent activation of store‐operated Ca 2+ entry via ...
Mark VerMeer, KIM TRAN
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环境与职业医学, 2022 BackgroundIt has been found that fluoride may cause cell damage by inducing intracellular calcium overload. Store-operated calcium entry (SOCE) plays an important role in maintaining intracellular calcium homeostasis, but the effect of fluoride on renal ...
Xuan WU, Fan DING, Yingying LIU, Qing WU
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Genetic polymorphisms of stromal interaction molecule 1 associated with the erythrocyte sedimentation rate and C-reactive protein in HLA-B27 positive ankylosing spondylitis patients. [PDF]
PLoS ONE, 2012 Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. The development of ankylosing spondylitis is still unclear.
James Cheng-Chung Wei +8 more
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An essential role for stromal interaction molecule 1 in neointima formation following arterial injury [PDF]
Cardiovascular Research, 2008 There is evidence to suggest that stromal interaction molecule 1 (STIM1) functions as a Ca2+ sensor on the endoplasmic reticulum, leading to transduction of signals to the plasma membrane and opening of store-operated Ca2+ channels (SOC). SOC have been detected in vascular smooth muscle cells (VSMCs) and are thought to have an essential role in the ...
Rui-Wei, Guo +9 more
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Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency [PDF]
The Journal of Immunology, 2012 Abstract Stromal interaction molecule 1 (STIM1) deficiency is a rare genetic disorder of store-operated calcium entry, associated with a complex syndrome including immunodeficiency and immune dysregulation. The link from the molecular defect to these clinical manifestations is incompletely understood.
Fuchs, Sebastian +19 more
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Endothelin Receptor Signaling: New Insight Into Its Regulatory Mechanisms
Journal of Pharmacological Sciences, 2013 The endothelin (ET) system consists of two G protein coupled–receptors (GPCRs), ET type A receptor (ETAR) and ET type B receptor (ETBR), and three endogenous ligands, ET-1, ET-2, and ET-3.
Takahiro Horinouchi +3 more
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Stromal interaction molecule 1 plays an important role in gastric cancer progression
Oncology Reports, 2016 Studies have shown that stromal interaction molecule 1 (STIM1) is expressed in a variety of cancers and is related to tumor growth. The present study aimed to investigate the expression and roles of STIM1 in gastric carcinoma. Immunohistochemistry and western blotting revealed that STIM1 was expressed at higher levels in gastric cancer tissues (82 ...
Jin-Mei, Xu +5 more
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POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters [PDF]
Proceedings of the National Academy of Sciences, 2011 Specialized proteins in the plasma membrane, endoplasmic reticulum (ER), and mitochondria tightly regulate intracellular calcium. A unique mechanism called store-operated calcium entry is activated when ER calcium is depleted, serving to restore intra-ER calcium levels.
Grigory, Krapivinsky +4 more
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Calcium sensing by the STIM1 ER-luminal domain
Nature Communications, 2018 Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological ...
Aparna Gudlur +10 more
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Stromal interaction molecule 1 promotes tumor growth in Esophageal squamous cell carcinoma
Genomics, 2020 Esophageal squamous cell carcinoma (ESCC) is a disease with poor prognosis which urgently is in need of effective prognostic marker. To discover novel prognostic protein marker for ESCC, we applied a high-throughput monoclonal antibody microarray to compare tumor and adjacent non-tumor tissues from ESCC patients.
Jian, Tang +5 more
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