Results 11 to 20 of about 32,791,583 (267)

Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle [PDF]

Cells, 2021
Calsequestrin 1 (CASQ1) in skeletal muscle buffers and senses Ca2+ in the sarcoplasmic reticulum (SR). CASQ1 also regulates store-operated Ca2+ entry (SOCE) by binding to stromal interaction molecule 1 (STIM1). Abnormal SOCE and/or abnormal expression or
Seung Yeon Jeong, Mi Ri Oh, Jun Hee Choi, Jin Seok Woo, Eun Hui Lee   +4 more
doaj   +4 more sources

Swing-out opening of stromal interaction molecule 1. [PDF]

Protein Sci, 2023
AbstractStromal interaction molecule 1 (STIM1) resides in the endoplasmic reticulum (ER) membrane and senses luminal calcium (Ca2+) concentration. STIM1 activation involves a large‐scale conformational transition that exposes a STIM1 domain termed “CAD/SOAR”, ‐ which is required for activation of the calcium channel Orai. Under resting cell conditions,
Horvath F, Berlansky S, Maltan L, Grabmayr H, Fahrner M, Derler I, Romanin C, Renger T, Krobath H.   +8 more
europepmc   +5 more sources

Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction. [PDF]

Circ Res, 2017
Rationale: Pathological increases in cardiac afterload result in myocyte hypertrophy with changes in myocyte electrical and mechanical phenotype. Remodeling of contractile and signaling Ca 2+ occurs in pathological hypertrophy and is central to myocyte ...
Troupes CD, Wallner M, Borghetti G, Zhang C, Mohsin S, von Lewinski D, Berretta RM, Kubo H, Chen X, Soboloff J, Houser S.   +10 more
europepmc   +5 more sources

Critical Role for Stromal Interaction Molecule 1 in Cardiac Hypertrophy [PDF]

Circulation, 2011
Background— Cardiomyocytes use Ca 2+ not only in excitation-contraction coupling but also as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely unclear how Ca 2+ triggers signaling in cardiomyocytes in the presence of the rapid ...
Hulot, S., Fauconnier, J., Ramanujam, D., Chaanine, A., Aubart, F., Sassi, Y., Merkle, S., Cazorla, Olivier, Ouille, A., Dupuis, M., Hadri, L., Jeong, D., Muhlstedt, S., Schmitt, J., Braun, A., Bénard, L., Saliba, Y., Laggerbauer, B., Nieswandt, B., Lacampagne, Alain, Hajjar, R., Lompre, A.-M., Engelhardt, S.   +22 more
openaire   +4 more sources

miR-185 silencing promotes the progression of atherosclerosis via targeting stromal interaction molecule 1. [PDF]

Cell Cycle, 2019
Atherosclerosis (AS) is a major risk factor for cardiovascular disease. microRNAs play a key role in gene regulation in the formation and development of atherosclerotic plaques. Herein, the role and target gene of miR-185 in AS were explored.Cell viability, migration and invasion were examined by cell counting kit-8 (CCK-8) and transwell assay.
Fang M, Li Y, Wu Y, Ning Z, Wang X, Li X.   +5 more
europepmc   +5 more sources

Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke

Pflügers Archiv - European Journal of Physiology, 2021
Stroke represents a main cause of death and permanent disability worldwide. In the attempt to develop targeted preventive and therapeutic strategies, several efforts were performed over the last decades to identify the specific molecular abnormalities preceding cerebral ischemia and neuronal death.
Stanzione, Rosita, Forte, Maurizio, Cotugno, Maria, Bianchi, Franca, Marchitti, Simona, Rubattu, Speranza   +5 more
openaire   +4 more sources

A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1). [PDF]

J Biol Chem, 2014
Store-operated Ca(2+) entry, essential for the adaptive immunity, is initiated by the endoplasmic reticulum (ER) Ca(2+) sensor STIM1. Ca(2+) entry occurs through the plasma membrane resident Ca(2+) channel Orai1 that directly interacts with the C-terminal STIM1 domain, named SOAR/CAD.
Fahrner M, Muik M, Schindl R, Butorac C, Stathopulos P, Zheng L, Jardin I, Ikura M, Romanin C.   +8 more
europepmc   +5 more sources

Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1). [PDF]

J Biol Chem, 2016
Calcium flux through store-operated calcium entry is a central regulator of intracellular calcium signaling. The two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction ...
Palty R, Isacoff EY.
europepmc   +4 more sources

Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins [PDF]

Cells, 2018
The incidence of colorectal cancer (CRC) has significantly increased in recent decades, and this disease has become an important health issue worldwide. Currently, there is no useful prognostic or diagnostic biomarker for CRC.
Chien-Yu Huang, Po-Li Wei, Wei-Yu Chen, Wei-Chiao Chang, Yu-Jia Chang   +4 more
doaj   +2 more sources

Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency [PDF]

The Journal of Immunology, 2012
Abstract Stromal interaction molecule 1 (STIM1) deficiency is a rare genetic disorder of store-operated calcium entry, associated with a complex syndrome including immunodeficiency and immune dysregulation. The link from the molecular defect to these clinical manifestations is incompletely understood.
Fuchs, Sebastian, Rensing-Ehl, Anne, Speckmann, Carsten, Bengsch, Bertram, Schmitt-Gräff, Annette, Bondzio, Ilka, Maul-Pavicic, Andrea, Bass, Thilo, Vraetz, Thomas, Strahm, Brigitte, Ankermann, Tobias, Benson, Melina, Caliebe, Almuth, Foelster-Holst, Regina, Kaiser, Petra, Thimme, Robert, Schamel, Wolfgang, Schwarz, Klaus, Feske, Stefan, Ehl, Stephan   +19 more
openaire   +5 more sources