Results 21 to 30 of about 32,791,583 (267)

Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans. [PDF]

Circ Arrhythm Electrophysiol, 2019
Cacheux M, Strauss B, Raad N, Ilkan Z, Hu J, Benard L, Feske S, Hulot JS, Akar FG.   +8 more
europepmc   +2 more sources

Paraquat is an agonist of STIM1 and increases intracellular calcium levels

Communications Biology, 2022
The herbicide paraquat is an agonist of Stromal Interaction Molecule 1 (STIM1), leading to extracellular calcium entry observed in epithelial-mesenchymal transition in alveolar cells during pulmonary fibrosis.
Wenyu Yang, Rui Tian, Yong Zhu, Peijie Huang, Xinrun Ma, Xiaoxiao Meng, Wentao Dai, Yiming Tao, Daonan Chen, Jiaxiang Zhang, Jian Lu, Hui Xie, Xiangdong Jian, Zhengfeng Yang, Ruilan Wang   +14 more
doaj   +1 more source

Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload [PDF]

Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload
Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+- dependent signal that promotes cardiac hypertrophy. However, whether STIM1 has adaptive role that helps to protect against cardiac overload stress remains unknown.
Iino, Kenji, Watanabe, Hiroyuki, Baba, Yoshihiro, Adachi, Takeshi, Ohba, Takayoshi, Ono, Kyoichi, Ito, Hiroshi, Murakami, Manabu, Kurosaki, Tomohiro   +8 more
openaire   +2 more sources

The Function of Stromal Interaction Molecule 1 (STIM1) in Heart [PDF]

Biophysical Journal, 2016
Stromal interaction molecule 1 (STIM1), an ER/SR Ca2+ sensor, has been well described as an activator of store-operated calcium channel (SOCC) Orai1 or the equivalents, upon SR/ER (Sarco/endoplasmic reticulum) Ca2+ depletion in many cell types. In heart, however, we found that the canonical actions of STIM1 do not apply.
Zhao, Guiling, Zhang, Hengtao, Li, Tianyu, Brochet, Didier X.P., Rosenberg, Paul, Lederer, W. Jonathan   +5 more
openaire   +1 more source

Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca²⁺ Signaling in Nasopharyngeal Carcinoma

Pathogens, 2021
Epstein-Barr virus (EBV) promotes tumor angiogenesis in nasopharyngeal carcinoma (NPC) by activating store-operated Ca2+ entry. Since such entry has been linked to stromal interaction molecule 1 (STIM1), we examined whether the virus acts via STIM1 ...
Jiaxiang Ye, Jiazhang Wei, Yue Luo, Yayan Deng, Ting Que, Xiaojian Zhang, Fei Liu, Jinyan Zhang, Xiaoling Luo   +8 more
doaj   +1 more source

Germline Genetic Association between Stromal Interaction Molecule 1 (STIM1) and Clinical Outcomes in Breast Cancer Patients. [PDF]

J Pers Med, 2020
Among all cancers in women, breast cancer has the highest incidence. The mortality of breast cancer is highly associated with metastasis. Migration and malignant transformation of cancer cells have been reported to be modulated by store-operated calcium (
Huang CC, Lin MR, Yang YC, Hsu YW, Wong HS, Chang WC.   +5 more
europepmc   +2 more sources

Essential role for smooth muscle cell stromal interaction molecule-1 in myocardial infarction. [PDF]

J Hypertens, 2018
Stromal interacting molecule-1 (STIM1) plays a role in coordinating calcium signaling in different cell types. The increase or deletion of STIM1 expression in cardiomyocyte causes cardiac complication. Moreover, the deletion of STIM1 in endothelial cell causes vascular endothelial dysfunction.
Mali V, Haddox S, Belmadani S, Matrougui K.   +3 more
europepmc   +4 more sources

Differential role for stromal interacting molecule 1 in the regulation of vascular function [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
We determined the in vivo role of stromal-interacting molecule 1 (STIM1) in the regulation of vascular function using endothelial cell (EC)- and smooth-muscle (SM)-specific knockout mice. Systolic blood pressure and glucose levels were similar in all mice (Stim1(SMC-/-), Stim1(SMC-/+), Stim1(EC-/-), Stim1(EC-/+)), but body weight was reduced in Stim1 ...
Modar, Kassan, Wei, Zhang, Karima Ait, Aissa, Judith, Stolwijk, Mohamed, Trebak, Khalid, Matrougui   +5 more
openaire   +2 more sources

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

eLife, 2022
The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function.
Tiantian Wei, Jue Wang, Ruqi Liang, Wendong Chen, Yilan Chen, Mingzhe Ma, An He, Yifei Du, Wenjing Zhou, Zhiying Zhang, Xin Zeng, Chu Wang, Jin Lu, Xing Guo, Xiao-Wei Chen, Youjun Wang, Ruijun Tian, Junyu Xiao, Xiaoguang Lei   +18 more
doaj   +1 more source

Knockdown of stromal interaction molecule 1 inhibits proliferation of colorectal cancer cells by inducing apoptosis. [PDF]

Oncol Lett, 2018
Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca2+ sensor which has been reported to be overexpressed in numerous types of cancer, and is involved in the cell proliferation, invasion, migration and metastasis frequently observed in cancer. However, the role of STIM1 in colorectal cancer (CRC) remains unknown.
Yang D, Dai X, Li K, Xie Y, Zhao J, Dong M, Yu H, Kong Z.   +7 more
europepmc   +4 more sources