Relative contributions of stromal interaction molecule 1 and CalDAG‐GEFI to calcium‐dependent platelet activation and thrombosis [PDF]
Journal of Thrombosis and Haemostasis, 2011 Stromal interaction molecule 1 (STIM1) was recently identified as a critical component of store-operated calcium entry (SOCE) in platelets. We previously reported the Ca(2+) -sensing guanine nucleotide exchange factor CalDAG-GEFI as a critical molecule in Ca(2+) signaling in platelets.To evaluate the contribution of STIM1/SOCE to Ca(2+) -dependent ...
Firdos Ahmad
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Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans [PDF]
Circulation: Arrhythmia and Electrophysiology, 2019 Zeki Ilkan, Stefan Feske, Fadi G Akar
exaly +2 more sources
Paraquat is an agonist of STIM1 and increases intracellular calcium levels
Communications Biology, 2022 The herbicide paraquat is an agonist of Stromal Interaction Molecule 1 (STIM1), leading to extracellular calcium entry observed in epithelial-mesenchymal transition in alveolar cells during pulmonary fibrosis.
Wenyu Yang +14 more
doaj +1 more source
Critical Role for Stromal Interaction Molecule 1 in Cardiac Hypertrophy [PDF]
Circulation, 2011 Background— Cardiomyocytes use Ca 2+ not only in excitation-contraction coupling but also as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely unclear how Ca 2+ triggers signaling in cardiomyocytes in the presence of the rapid ...
Hulot, S. +22 more
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Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1) [PDF]
Journal of Biological Chemistry, 2016 Raz Palty, Ehud Y Isacoff
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Pathogens, 2021 Epstein-Barr virus (EBV) promotes tumor angiogenesis in nasopharyngeal carcinoma (NPC) by activating store-operated Ca2+ entry. Since such entry has been linked to stromal interaction molecule 1 (STIM1), we examined whether the virus acts via STIM1 ...
Jiaxiang Ye +8 more
doaj +1 more source
The Function of Stromal Interaction Molecule 1 (STIM1) in Heart [PDF]
Biophysical Journal, 2016 Stromal interaction molecule 1 (STIM1), an ER/SR Ca2+ sensor, has been well described as an activator of store-operated calcium channel (SOCC) Orai1 or the equivalents, upon SR/ER (Sarco/endoplasmic reticulum) Ca2+ depletion in many cell types. In heart, however, we found that the canonical actions of STIM1 do not apply.
Zhao, Guiling +5 more
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Differential role for stromal interacting molecule 1 in the regulation of vascular function [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 We determined the in vivo role of stromal-interacting molecule 1 (STIM1) in the regulation of vascular function using endothelial cell (EC)- and smooth-muscle (SM)-specific knockout mice. Systolic blood pressure and glucose levels were similar in all mice (Stim1(SMC-/-), Stim1(SMC-/+), Stim1(EC-/-), Stim1(EC-/+)), but body weight was reduced in Stim1 ...
Modar, Kassan +5 more
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Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry
eLife, 2022 The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function.
Tiantian Wei +18 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Emerging data suggest that CLL-cells efficiently evade immunosurveillance. T-cell deficiencies in CLL include immuno(metabolic) exhaustion that is achieved by inhibitory molecules,
Paolo Ghia +9 more
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