Results 51 to 60 of about 32,791,583 (267)

A gastrointestinal stromal tumor (GIST) masquerading as an ovarian mass [PDF]

, 2004
Background Malignant gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating in the wall of the gastrointestinal tract. Myogenic gastrointestinal stromal tumor, a distinctive morphologic variant is characterized by an unusually ...
CARLOMAGNO, Giorgio, Carlomagno Giorgio, Beneduce Pasquale, B. E. N. E. D. U. C. E. P. A. Gastrointestinal Stromal Tumor Gist Masquerading As An Ovarian Mass   +3 more
core   +1 more source

Conformational Switching Mechanisms Underlying the Activation of Stromal Interaction Molecule 1 (STIM1) [PDF]

Biophysical Journal, 2013
Physiological Ca2+ signalling in T lymphocytes and various other mammalian cells depends on the STIM-ORAI pathway of store-operated Ca2+ entry. STIM1 and STIM2 are Ca2+ sensors located in the endoplasmic reticulum (ER) membrane, with ER-luminal domains that monitor cellular Ca2+ stores and cytoplasmic domains that gate ORAI channels in the plasma ...
Zhou, Yubin, Seymour, Sam, Razavi, Shiva, Meraner, Paul, Rao, Anjana, Hogan, Patrick G.   +5 more
openaire   +1 more source

Munc 18-1 Protein Molecules Move between Membrane Molecular Depots Distinct from Vesicle Docking Sites [PDF]

, 2013
Four evolutionarily conserved proteins are required for mammalian regulated exocytosis: three SNARE proteins, syntaxin, SNAP-25, and synaptobrevin, and the SM protein, Munc18-1. Here, using single-molecule imaging, we measured the spatial distribution of
Rickman, Colin, Lu, Weiping, Yang, Lei, Hamilton, Charlotte, Smyth, Annya M., Cousin, Michael A., Rickman, Colin; id_orcid, Martin, Kirsty J., Duncan, Rory R., Cousin, Michael A.; id_orcid   +9 more
core   +1 more source

STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling

Cell Reports, 2017
Summary: Potentiation of synaptic strength relies on postsynaptic Ca2+ signals, modification of dendritic spine structure, and changes in gene expression.
Philip J. Dittmer, Angela R. Wild, Mark L. Dell’Acqua, William A. Sather   +3 more
doaj   +1 more source

Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions

Cells, 2022
Orai1, the Ca2+-selective pore in the plasma membrane, is one of the key components of the Ca2+release-activated Ca2+ (CRAC) channel complex. Activated by the Ca2+ sensor in the endoplasmic reticulum (ER) membrane, stromal interaction molecule 1 (STIM1),
Christina Humer, Christoph Romanin, Carmen Höglinger   +2 more
doaj   +1 more source

Hydrogen peroxide disrupts the regulatory pathway of saliva secretion in two salivary acinar rat cell lines

Frontiers in Molecular Biosciences
BackgroundSecretion of saliva is controlled by autonomic nerve signals via regulation of Ca2+-dependent ion transport across acinar cell membranes. Oxidative stress may affect this process, leading to a decrease in saliva production.
Golnaz Golnarnik, Tine M. Søland, Hilde K. Galtung, Trude M. Haug   +3 more
doaj   +1 more source

Chlamydia trachomatis suppresses host cell store-operated Ca2+ entry and inhibits NFAT/calcineurin signaling

Scientific Reports, 2022
The obligate intracellular bacterium, Chlamydia trachomatis, replicates within a parasitophorous vacuole termed an inclusion. During development, host proteins critical for regulating intracellular calcium (Ca2+) homeostasis interact with the inclusion ...
Nicholas B. Chamberlain, Zoe Dimond, Ted Hackstadt   +2 more
doaj   +1 more source

Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus [PDF]

, 2012
The junctional adhesion molecule (JAM)-C is a widely expressed adhesion molecule regulating cell adhesion, cell polarity and inflammation. JAM-C expression and function in the central nervous system (CNS) has been poorly characterized to date.
Michel Mittelbronn, Imhof, Beat A., Aurrand-Lions, Michel, Michel Aurrand-Lions, Deutsch, Urban, Karl H Plate, Adams, Ralf H, Liebner, Stefan, Schäfer, Julia, Enzmann, Gaby, Plate, Karl H, Urban Deutsch, Beat A Imhof, Adams, Ralf Heinrich, Mittelbronn, Michel, Imhof, Beat, Mittelbronn, Michel Guy André, Plate, Karl, Gaby Enzmann, Ralf H Adams, Engelhardt, Britta, Britta Engelhardt, Lena Wyss, Stefan Liebner, Plate, Karl H., Julia Schäfer, Wyss, Lena, Adams, Ralf H.   +27 more
core   +3 more sources

Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers. [PDF]

Oncotarget, 2015
STIM1 overexpression has been observed in a portion of colorectal cancer (CRC) patients and associated with cancer cell invasion and migration. To characterize the distinctive expression profiles associated with stromal interaction molecule 1 (STIM1) overexpression/low-expression between CRC subtypes, and further assess the divergence transcription ...
Wong HS, Chang WC.
europepmc   +4 more sources

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos [PDF]

, 2012
Background The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos.
Weimar, Charlotte H. E., Gellersen, Birgit, Heijnen Cobi J., Johanna M T de Vreeden-Elbertse, Jan J. Brosens (109247), de Vreeden-Elbertse Johanna M. T., de Vreeden-Elbertse, Johanna M.T., Nick S Macklon, Macklon Nick S., Kavelaars, Annemieke, Charlotte H. E. Weimar (148304), Nick S. Macklon (148320), Jan J Brosens, Weimar Charlotte H. E., Gellersen Birgit, Cobi J. Heijnen (148314), Brosens Jan J., Macklon, Nick S., Weimar, Charlotte H.E., Kavelaars Annemieke, Cobi J Heijnen, Charlotte H E Weimar, Birgit Gellersen (148307), de Vreeden-Elbertse, Johanna M. T., Brosens, Jan J., Heijnen, Cobi J., Annemieke Kavelaars, Annemieke Kavelaars (12570), Birgit Gellersen, Johanna M. T. de Vreeden-Elbertse (148309)   +29 more
core   +2 more sources