Results 71 to 80 of about 74,552 (234)

Role of store-operated Ca2+ entry in cardiovascular disease

Cell Communication and Signaling, 2022
Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in non-excitable and excitable (i.e., skeletal and cardiac muscle) cells.
Ting Lu, Yihua Zhang, Yong Su, Dayan Zhou, Qiang Xu   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Zinc binding to a conserved motif in STIM1 induces clustering and SOCE activation

Cell Communication and Signaling
Background STIM1 is a key regulator of calcium homeostasis in the endoplasmic reticulum (ER), activated upon ER calcium depletion through calcium dissociation from its EF-hand domain.
Benedicte Alary, Viktoriia E. Baksheeva, Sabrina Beaumier, Géraldine Ferracci, Claude Villard, Andrey V. Golovin, Sébastien Courrier, François Devred, Marc Bartoli, Philipp O. Tsvetkov   +9 more
doaj   +1 more source

Mechanism of Scutellaria baicalensis extracellular vesicles in attenuating Mycoplasma gallisepticum-induced inflammation via TRPC1 - STIM1/ORAI1 channel inhibition

Poultry Science
Abstact: Major Objectives: The infection caused by Mycoplasma gallisepticum (MG) has had a significant impact on the poultry industry. Scutellaria baicalensis extract has shown great potential in anti-MG infection, but the role and mechanism of its ...
Fangbing Xu, Lige Bao, Yecheng Yao, Yifan Li, Yu Liu, Mingyu Yu, Shun Wang, Weiqi Liu, Zhiyong Wu   +8 more
doaj   +1 more source

STIM1 Mediates Hypoxia-Driven Hepatocarcinogenesis via Interaction with HIF-1

Cell Reports, 2015
Hypoxia and intracellular Ca2+ transients are fundamental traits of cancer, whereas the route and regulation of Ca2+ mobilization in hypoxic tumorigenesis are unknown.
Yongsheng Li, Bo Guo, Qichao Xie, Duyun Ye, Dongxin Zhang, Ying Zhu, Hongxiang Chen, Bo Zhu   +7 more
doaj   +1 more source

TRPP2 and STIM1 form a microdomain to regulate store-operated Ca2+ entry and blood vessel tone

Cell Communication and Signaling, 2020
Background Polycystin-2 (TRPP2) is a Ca2+ permeable nonselective cationic channel essential for maintaining physiological function in live cells. Stromal interaction molecule 1 (STIM1) is an important Ca2+ sensor in store-operated Ca2+ entry (SOCE). Both
Jizheng Guo, Ren Zhao, Muyao Zhou, Jie Li, Xiaoqiang Yao, Juan Du, Jiexia Chen, Bing Shen   +7 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes.

PLoS Biology, 2020
Trimeric intracellular cation (TRIC) channels have been proposed to modulate Ca2+ release from the endoplasmic reticulum (ER) and determine oscillatory Ca2+ signals.
Niroj Shrestha, Bernadett Bacsa, Hwei Ling Ong, Susanne Scheruebel, Helmut Bischof, Roland Malli, Indu Suresh Ambudkar, Klaus Groschner   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source