Results 91 to 100 of about 32,791,583 (267)

CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1

Cellular Physiology and Biochemistry, 2018
Background/Aims: Upon Ca2+ store depletion, stromal interaction molecule 1 (STIM1) oligomerizes, redistributes near plasmalemma to interact with Ca2+ selective channel-forming subunit (Orai1) and initiates store-operated Ca2+ entry (SOCE).
Shu Li, Jingyi Xue, Zhipeng Sun, Tiantian Liu, Lane Zhang, Limin Wang, Hongjie You, Zheng Fan, Yuanyuan Zheng, Dali Luo   +9 more
doaj   +1 more source

Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity

, 2015
The thrombospondins (TSPs) are a family of matricellular proteins that regulate cellular phenotype through interactions with a myriad of other proteins and proteoglycans.
Thompson, Jill, Lawler, Jack, Duquette, Mark, Okuhara, Dayne, Shuttleworth, Trevor, Nadler, Monica   +5 more
core   +1 more source

Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo [PDF]

, 2004
We have investigated the contribution of the tight junction (TJ) transmembrane protein junction-adhesion-molecule 1 (JAM-1) to trophectoderm epithelial differentiation in the mouse embryo.
Fay C. Thomas, Dejana, E., Bhavwanti Sheth, Tom P. Fleming, Fleming, T.P., Sheth, B., Judith J. Eckert, Gianfranco Bazzoni, Elisabetta Dejana, Bazzoni, G., Thomas, F.C., Eckert, J.J.   +11 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Strukturelle und funktionelle Untersuchungen des Stromal Interaction Molecule 1

, 2022
Calcium (Ca2+) ist ein wichtiger zellulärer Botenstoff, der an biologischen Signalprozessen, die für Befruchtung, Genexpression, Zellwachstum und Zelldifferenzierung, Immunabwehr, Muskelkontraktion sowie Apoptose erforderlich sind, beteiligt ist ...
Grabmayr, Herwig Reinhard
core   +1 more source

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis

Breast Cancer Research, 2019
Background Stromal interaction molecule (STIM) 2 is a key calcium-sensing molecule that regulates the stabilization of calcium ions (Ca2+) and therefore regulates downstream Ca2+-associated signaling and cellular events.
Yutian Miao, Qiang Shen, Siheng Zhang, Hehai Huang, Xiaojing Meng, Xianchong Zheng, Zhuocheng Yao, Zhanxin He, Sitong Lu, Chunqing Cai, Fei Zou   +10 more
doaj   +1 more source

Engineered three-dimensional microenvironments as functional in vitro models of stromal tissues [PDF]

, 2014
Currently, the majority of current cultures is still carried out with long-established techniques like the exploitation of 2D supports, the use of tissue-derived immortalized cell lines, and the administration of un-physiological doses of soluble factors
Piccinini, Elia
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Role of store-operated Ca2+ entry in cardiovascular disease

Cell Communication and Signaling, 2022
Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in non-excitable and excitable (i.e., skeletal and cardiac muscle) cells.
Ting Lu, Yihua Zhang, Yong Su, Dayan Zhou, Qiang Xu   +4 more
doaj   +1 more source

Stromal-Interacting Molecule 1 (Stim1)/Orai1 Modulates Endothelial Permeability in Ventilator-Induced Lung Injury [PDF]

Medical Science Monitor, 2018
BACKGROUND Increased endothelial permeability is involved in ventilator-induced lung injury (VILI). Stim1/Orai1 mediates store-operated Ca2+ activation, which modulates endothelial permeability. However, the underlying mechanisms of the Stim1/Orai1 pathway in VILI are poorly understood. MATERIAL AND METHODS Wistar rats were exposed to low tidal volume (
Song, Xiumei, Liu, Yang, Dong, Ling, Wang, Yuelan   +3 more
openaire   +2 more sources