Results 101 to 110 of about 32,791,583 (267)

Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors [PDF]

, 2013
AIM: To investigate primarily the prognostic value of Ki-67, as well as other parameters, in gastrointestinal stromal tumors (GISTs). ----- METHODS: Ki-67, c-KIT, platelet-derived growth factor receptor-alpha (PDGFRα), smooth muscle actin (SMA ...
Alerić, Ivan, Boban, Marko, Antunac Golubić, Zrna, Prejac, Juraj, Vrbanec, Damir, Brčić, Iva, Belev, Borislav, Jakić Razumović, Jasminka, Božikov, Jadranka   +8 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Zinc binding to a conserved motif in STIM1 induces clustering and SOCE activation

Cell Communication and Signaling
Background STIM1 is a key regulator of calcium homeostasis in the endoplasmic reticulum (ER), activated upon ER calcium depletion through calcium dissociation from its EF-hand domain.
Benedicte Alary, Viktoriia E. Baksheeva, Sabrina Beaumier, Géraldine Ferracci, Claude Villard, Andrey V. Golovin, Sébastien Courrier, François Devred, Marc Bartoli, Philipp O. Tsvetkov   +9 more
doaj   +1 more source

Mechanism of Scutellaria baicalensis extracellular vesicles in attenuating Mycoplasma gallisepticum-induced inflammation via TRPC1 - STIM1/ORAI1 channel inhibition

Poultry Science
Abstact: Major Objectives: The infection caused by Mycoplasma gallisepticum (MG) has had a significant impact on the poultry industry. Scutellaria baicalensis extract has shown great potential in anti-MG infection, but the role and mechanism of its ...
Fangbing Xu, Lige Bao, Yecheng Yao, Yifan Li, Yu Liu, Mingyu Yu, Shun Wang, Weiqi Liu, Zhiyong Wu   +8 more
doaj   +1 more source

STIM1 Mediates Hypoxia-Driven Hepatocarcinogenesis via Interaction with HIF-1

Cell Reports, 2015
Hypoxia and intracellular Ca2+ transients are fundamental traits of cancer, whereas the route and regulation of Ca2+ mobilization in hypoxic tumorigenesis are unknown.
Yongsheng Li, Bo Guo, Qichao Xie, Duyun Ye, Dongxin Zhang, Ying Zhu, Hongxiang Chen, Bo Zhu   +7 more
doaj   +1 more source

TRPP2 and STIM1 form a microdomain to regulate store-operated Ca2+ entry and blood vessel tone

Cell Communication and Signaling, 2020
Background Polycystin-2 (TRPP2) is a Ca2+ permeable nonselective cationic channel essential for maintaining physiological function in live cells. Stromal interaction molecule 1 (STIM1) is an important Ca2+ sensor in store-operated Ca2+ entry (SOCE). Both
Jizheng Guo, Ren Zhao, Muyao Zhou, Jie Li, Xiaoqiang Yao, Juan Du, Jiexia Chen, Bing Shen   +7 more
doaj   +1 more source

Transcriptional Profiling of Bone Marrow Stromal Cells in Response to Porphyromonas gingivalis Secreted Products [PDF]

, 2012
Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting (periodontal) tissues. Porphyromonas gingivalis is an oral pathogen highly implicated in the pathogenesis of this disease.
Reddi, D, Belibasakis, GN, Belibasakis, Georgios N, Durga Reddi (140451), Georgios N Belibasakis, Reddi, Durga, Georgios N. Belibasakis (140456), Reddi Durga, Durga Reddi, Belibasakis Georgios N.   +9 more
core   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes.

PLoS Biology, 2020
Trimeric intracellular cation (TRIC) channels have been proposed to modulate Ca2+ release from the endoplasmic reticulum (ER) and determine oscillatory Ca2+ signals.
Niroj Shrestha, Bernadett Bacsa, Hwei Ling Ong, Susanne Scheruebel, Helmut Bischof, Roland Malli, Indu Suresh Ambudkar, Klaus Groschner   +7 more
doaj   +1 more source

Charakterisierung des "Stromal interaction molecule 1" (STIM1) im Myocardium

, 2015
Ca2+ is the ubiquitous second messenger that not only modulates excitation-contraction coupling in cardiomyocytes, but is also an important trigger for transcriptional activation during pathological cardiac remodelling.
Ramanujam, Deepak Prabhu
core