Results 111 to 120 of about 32,791,583 (267)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Crystal Structure of the Neutralizing Llama V-HH D7 and Its Mode of HIV-1 gp120 Interaction [PDF]

, 2010
HIV-1 entry into host cells is mediated by the sequential binding of the envelope glycoprotein gp120 to CD4 and a chemokine receptor. Antibodies binding to epitopes overlapping the CD4-binding site on gp120 are potent inhibitors of HIV entry, such as the
de Haard, Hans, Gorlani, A, David Lutje Hulsik, Verrips, T, Verrips, Theo, Hassan Belrhali, Weissenhorn Winfried, Anna Forsman, Gorlani Andrea, Hulsik, David Lutje, Andreas Hinz, de Haard, H, Belrhali, H, Andrea Gorlani, Forsman Anna, Verrips Theo, Weiss, RA, Weiss Robin A., Willie Wee-Lee Koh, Belrhali Hassan, Hinz Andreas, Lutje Hulsik David, Koh Willie Wee-Lee, Hinz, Andreas, Forsman, A, Winfried Weissenhorn, Belrhali, Hassan, Koh, Willie Wee-Lee, Robin A Weiss, Weissenhorn, W, Koh, WWL, Hulsik, DL, Weissenhorn, Winfried, Forsman, Anna, Theo Verrips, de Haard Hans, Hinz, A, Weiss, Robin A, Hans de Haard, Gorlani, Andrea   +39 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Potential inhibition of CXCL12/SDF-1 by small molecule Hesperetin in management of tobacco associated oral cancer

Oral Oncology Reports
Goal of the perspective: Stromal cell-derived factor-1 alpha CXCL12/SDF-1 has a substantial impact on the tumorigenicity in tobacco related oral cancer. Inhibition could help derive preventive and therapeutic approaches.
G. Radha, Ramya Ramadoss, Pradeep Kumar Yadalam, Rajeshkumar Shanmugam   +3 more
doaj   +1 more source

Stromal Interaction Molecule-1 (STIM1): Orchestrating Calcium Signaling in Cancer and Hematologic Malignancies

Journal of Angiotherapy, 2023
STIM-1 plays pivotal roles in carcinogenesis via calcium signalling. STIM-1 regulatory functions in malignancies were observed to be significantly implicated resulting in various oncogenic properties. STIM-1 induced oncogenic properties mainly via the store operated calcium entry (SOCE) disruption. Moreover, calcium signalling mediated via STIM-1 could
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Tweeters and Woofers: The Complex Orchestra of Calcium Currents in T Lymphocytes

Frontiers in Immunology, 2015
Elevation of intracellular calcium ion (Ca2+) levels is a vital event that regulates T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis.
Lilian L Nohara, Lilian L Nohara, Shawna R Stanwood, Shawna R Stanwood, Kyla D Omilusik, Kyla D Omilusik, Kyla D Omilusik, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies, Wilfred A Jefferies   +12 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Stromal interaction molecule 2 regulates C2C12 myoblast differentiation [PDF]

, 2015
BackgroundEnhanced intracellular Ca2+ signaling by stromal interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) is required for skeletal muscle differentiation.
Phuong, Tam Thi Thanh, Tam Thi Thanh Phuong, Tong Mook Kang, Kang, Tong Mook   +3 more
core   +1 more source