Results 41 to 50 of about 2,808,407 (277)
Cellular Physiology and Biochemistry, 2018 Background/Aims: Activation of stromal interaction molecule 1 (STIM1) and Orai1 participates in the development of cardiac hypertrophy. Store-operated Ca2+ entry-associated regulatory factor (SARAF) is an intrinsic inhibitor of STIM1-Orai1 interaction ...
Fengdan Dai +6 more
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Studies on the role of Coronin 1 and the actin cytoskeleton in T cell signaling and survival [PDF]
, 2009 Calcium ions (Ca2+) function as universal second messengers in most if not all eukaryotic cells, including the cells of the immunesystem. Ca2+ signals are required for the proper activation of lymphocytes, such as T-lymphocytes, their proliferation ...
Müller, Philipp
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The role of endothelial leak in pulmonary hypertension (2017 Grover Conference Series)
Pulmonary Circulation, 2018 The canonical transient receptor potential 4 (TRPC4) protein contributes to the molecular make-up of endothelial store-operated calcium entry channels. Store-operated calcium entry is a prominent mode of calcium influx in endothelium.
Chun Zhou +3 more
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eLife, 2021 Harnessing single-molecule FRET illuminates the structural changes necessary for a protein to fine-tune the influx of calcium when reserves inside a cell run low.
Marc Fahrner, Christoph Romanin
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Cells, 2021 Store-operated calcium entry (SOCE) provided through channels formed by ORAI proteins is a major regulator of several cellular processes. In immune cells, it controls fundamental processes such as proliferation, cell adhesion, and migration, while in ...
Alexandre Bokhobza +4 more
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, 2020 Metabolic syndrome causes adverse effects on the coronary circulation including altered vascular responsiveness and the progression of coronary artery disease (CAD). However the underlying mechanisms linking obesity with CAD are intricated.
Sánchez Pina, Ana Alejandra +7 more
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Mitochondrial DNA mutations affect calcium handling in differentiated neurons. [PDF]
, 2010 Contains fulltext : 88975.pdf (Publisher’s version ) (Closed access)Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood ...
Enriquez, J.A. +26 more
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Store-independent modulation of Ca2+ entry through Orai by Septin 7
Nature Communications, 2016 Orai channels are well known to mediate store-operated calcium entry. Here authors show that in neurons of the Drosophilaflight circuit, Septin 7 acts as a negative regulator of Orai channels, surprisingly, by modulating store-independent calcium entry ...
Bipan Kumar Deb +2 more
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Molecular modulators of store-operated calcium entry
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016 Three decades ago, store-operated Ca(2+) entry (SOCE) was identified as a unique mechanism for Ca(2+) entry through plasma membrane (PM) Ca(2+)-permeable channels modulated by the intracellular Ca(2+) stores, mainly the endoplasmic reticulum (ER). Extensive analysis of the communication between the ER and the PM leads to the identification of the ...
Jose J. Lopez +5 more
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Store-operated calcium entry in differentiated C2C12 skeletal muscle cells [PDF]
, 2005 In this paper, we show further evidences for the existence of store-operated calcium entry in differentiated skeletal muscle C2C12 myotubes after Ca2+ depletion in sarcoplasmic reticulum, using thapsigargin, a potent sarcoplasmic reticulum Ca2+-ATPase ...
Henao, Fernando +5 more
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