Results 21 to 30 of about 2,808,407 (277)
Store-operated calcium entry in neuroglia [PDF]
Neuroscience Bulletin, 2013 Neuroglial cells are homeostatic neural cells. Generally, they are electrically non-excitable and their activation is associated with the generation of complex intracellular Ca(2+) signals that define the "Ca(2+) excitability" of glia. In mammalian glial cells the major source of Ca(2+) for this excitability is the lumen of the endoplasmic reticulum ...
Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898 +1 more
openaire +3 more sources
Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
eLife, 2021 The dimeric ER Ca2+ sensor STIM1 controls store-operated Ca2+ entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane.
Stijn van Dorp +7 more
doaj +1 more source
Reorganization and Suppression of Store-Operated Calcium Entry in Podocytes of Type 2 Diabetic Rats [PDF]
International Journal of Molecular Sciences, 2023 Kira Derkach +2 more
exaly +2 more sources
Inhibiting store-operated calcium entry attenuates white matter secondary degeneration following SCI
Neurobiology of Disease, 2020 Axonal degeneration plays a key role in the pathogenesis of numerous neurological disorders including spinal cord injury. After the irreversible destruction of the white matter elements during the primary (mechanical) injury, spared axons and their ...
Ben C. Orem +2 more
doaj +1 more source
Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
Cells, 2021 Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
doaj +1 more source
Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer
Frontiers in Pharmacology, 2021 Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells, and regulates a variety of cellular functions including proliferation, motility, apoptosis, and death.
Xiaojing Liang +5 more
doaj +1 more source
Store-operated calcium entry and diabetic complications [PDF]
Experimental Biology and Medicine, 2015 Store-operated Ca 2+ entry (SOCE) is mediated by the store-operated Ca 2+ channel (SOC) that opens upon depletion of internal Ca 2+ stores following activation of G protein-coupled receptors or receptor tyrosine ...
Sarika, Chaudhari, Rong, Ma
openaire +2 more sources
Store-operated calcium entry is reduced in spastin-linked hereditary spastic paraplegia [PDF]
, 2022 Pathogenic variants in SPAST, the gene coding for spastin, are the single most common cause of hereditary spastic paraplegia, a progressive motor neuron disease.
Rizo, Tania +13 more
core +1 more source
TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. Here we have used the induced pluripotent stem cell technology to produce patient-specific terminally ...
Vladimir A. Vigont +17 more
doaj +1 more source