Results 21 to 30 of about 11,100 (249)

CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines

IBRO Neuroscience Reports, 2022
Calcium/calmodulin-dependent protein kinase II (CaMKII) and neuronal store-operated calcium entry (nSOCE) have been implicated in the development of Alzheimer's disease (AD).
Nikita Zernov, Ilya Bezprozvanny, Elena Popugaeva   +2 more
doaj   +1 more source

Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.

PLoS ONE, 2009
Calcium is a messenger ion that controls all aspects of cone photoreceptor function, including synaptic release. The dynamic range of the cone output extends beyond the activation threshold for voltage-operated calcium entry, suggesting another calcium ...
Tamas Szikra, Peter Barabas, Theodore M Bartoletti, Wei Huang, Abram Akopian, Wallace B Thoreson, David Krizaj   +6 more
doaj   +1 more source

Store-Operated Calcium Entry in Skeletal Muscle: What Makes It Different?

Cells, 2021
Current knowledge on store-operated Ca2+ entry (SOCE) regarding its localization, kinetics, and regulation is mostly derived from studies performed in non-excitable cells.
Elena Lilliu, Stéphane Koenig, Xaver Koenig, Maud Frieden   +3 more
doaj   +1 more source

Overexpression of SARAF Ameliorates Pressure Overload–Induced Cardiac Hypertrophy Through Suppressing STIM1-Orai1 in Mice

Cellular Physiology and Biochemistry, 2018
Background/Aims: Activation of stromal interaction molecule 1 (STIM1) and Orai1 participates in the development of cardiac hypertrophy. Store-operated Ca2+ entry-associated regulatory factor (SARAF) is an intrinsic inhibitor of STIM1-Orai1 interaction ...
Fengdan Dai, Yan Zhang, Qiang Wang, De Li, Yongjian Yang, Shuangtao Ma, Dachun Yang   +6 more
doaj   +1 more source

Sulfhydryl modification induces calcium entry through IP₃-sensitive store-operated pathway in activation-dependent human neutrophils. [PDF]

PLoS ONE, 2011
As the first line of host defense, neutrophils are stimulated by pro-inflammatory cytokines from resting state, facilitating the execution of immunomodulatory functions in activation state.
Leiting Pan, Xian Wu, Dan Zhao, Nason Ma'ani Hessari, Imshik Lee, Xinzheng Zhang, Jingjun Xu   +6 more
doaj   +1 more source

The role of endothelial leak in pulmonary hypertension (2017 Grover Conference Series)

Pulmonary Circulation, 2018
The canonical transient receptor potential 4 (TRPC4) protein contributes to the molecular make-up of endothelial store-operated calcium entry channels. Store-operated calcium entry is a prominent mode of calcium influx in endothelium.
Chun Zhou, C. Michael Francis, Ningyong Xu, Troy Stevens   +3 more
doaj   +1 more source

The many states of STIM1

eLife, 2021
Harnessing single-molecule FRET illuminates the structural changes necessary for a protein to fine-tune the influx of calcium when reserves inside a cell run low.
Marc Fahrner, Christoph Romanin
doaj   +1 more source

Impact of SOCE Abolition by ORAI1 Knockout on the Proliferation, Adhesion, and Migration of HEK-293 Cells

Cells, 2021
Store-operated calcium entry (SOCE) provided through channels formed by ORAI proteins is a major regulator of several cellular processes. In immune cells, it controls fundamental processes such as proliferation, cell adhesion, and migration, while in ...
Alexandre Bokhobza, Nathalie Ziental-Gelus, Laurent Allart, Oksana Iamshanova, Fabien Vanden Abeele   +4 more
doaj   +1 more source

Store-independent modulation of Ca2+ entry through Orai by Septin 7

Nature Communications, 2016
Orai channels are well known to mediate store-operated calcium entry. Here authors show that in neurons of the Drosophilaflight circuit, Septin 7 acts as a negative regulator of Orai channels, surprisingly, by modulating store-independent calcium entry ...
Bipan Kumar Deb, Trayambak Pathak, Gaiti Hasan   +2 more
doaj   +1 more source

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes

Frontiers in Physiology, 2018
Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen, Hairuo Wen, Zhenghang Zhao, Nadezhda Fefelova, Lai-Hua Xie   +4 more
doaj   +1 more source