Results 31 to 40 of about 11,100 (249)
Regulation of store-operated calcium entry
, 2023 Plasma membrane calcium influx through ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP3), which binds to IP3 receptors in the endoplasmic reticulum (ER) to release calcium pools from the ER lumen.
Kodakandla, Goutham +2 more
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The importance of calcium in the regulation of megakaryocyte function
Haematologica, 2014 Platelet release by megakaryocytes is regulated by a concert of environmental and autocrine factors. We previously showed that constitutively released adenosine diphosphate by human megakaryocytes leads to platelet production. Here we show that adenosine
Christian Andrea Di Buduo +7 more
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ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets
Pharmaceuticals, 2023 The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators of cell function; therefore, calcium as a universal intracellular mediator is involved in very important human diseases and disorders.
Hussein N. Rubaiy
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Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry
Cell Reports, 2020 Summary: Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls cellular redox signaling and is itself regulated by redox modifications.
Christine Silvia Gibhardt +26 more
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CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A. [PDF]
PLoS ONE, 2018 The Chloride Channel Accessory (CLCA) protein family was first characterized as regulators of calcium-activated chloride channel (CaCC) currents (ICaCC), but the mechanism has not been fully established. We hypothesized that CLCAs might regulate ICaCC by
Aarushi Sharma +4 more
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Mechanism of store-operated calcium entry
Journal of Biosciences, 2000 Activation of receptors coupled to the phospholipase C/IP3 signalling pathway results in a rapid release of calcium from its intracellular stores, eventually leading to depletion of these stores. Calcium store depletion triggers an influx of extracellular calcium across the plasma membrane, a mechanism known as the store-operated calcium entry or ...
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The Physiological Function of Store-operated Calcium Entry [PDF]
Neurochemical Research, 2011 Store-operated Ca(2+) entry is a process whereby the depletion of intracellular Ca(2+) stores signals the opening of plasma membrane Ca(2+) channels. It has long been thought that the main function of store-operated Ca(2+) entry was the replenishment of intracellular Ca(2+) stores following their discharge during intracellular Ca(2+) signaling.
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Function, 2022 Cannabis sativa has long been known to affect numerous biological activities. Although plant extracts, purified cannabinoids, or synthetic cannabinoid analogs have shown therapeutic potential in pain, inflammation, seizure disorders, appetite stimulation,
Malika Faouzi +9 more
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Origins of the concept of store-operated calcium entry [PDF]
Frontiers in Bioscience, 2011 The concept of capacitative or store-operated calcium entry, a process by which the release of stored calcium signals the opening of plasma membrane calcium channels, has its roots in the late 1970's, and was formalized in 1986. This short introduction to the current volume of Frontiers in Bioscience briefly summarizes the early experimental work that ...
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Biological Research, 2019 Background Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats but the subcellular mechanism remains unclear.
Jinsen Lu +4 more
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