Results 51 to 60 of about 2,808,407 (277)
The importance of calcium in the regulation of megakaryocyte function
Haematologica, 2014 Platelet release by megakaryocytes is regulated by a concert of environmental and autocrine factors. We previously showed that constitutively released adenosine diphosphate by human megakaryocytes leads to platelet production. Here we show that adenosine
Christian Andrea Di Buduo +7 more
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ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets
Pharmaceuticals, 2023 The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators of cell function; therefore, calcium as a universal intracellular mediator is involved in very important human diseases and disorders.
Hussein N. Rubaiy
doaj +1 more source
ORMDL3 modulates store-operated calcium entry and lymphocyte activation. [PDF]
, 2013 T lymphocytes rely on a Ca(2+) signal known as store-operated calcium entry (SOCE) for their activation. This Ca(2+) signal is generated by activation of a T-cell receptor, depletion of endoplasmic reticulum (ER) Ca(2+) stores and activation of Ca(2 ...
Carreras-Sureda, Amado +7 more
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Mechanism of store-operated calcium entry
Journal of Biosciences, 2000 Activation of receptors coupled to the phospholipase C/IP3 signalling pathway results in a rapid release of calcium from its intracellular stores, eventually leading to depletion of these stores. Calcium store depletion triggers an influx of extracellular calcium across the plasma membrane, a mechanism known as the store-operated calcium entry or ...
openaire +2 more sources
Origins of the concept of store-operated calcium entry [PDF]
Frontiers in Bioscience, 2011 The concept of capacitative or store-operated calcium entry, a process by which the release of stored calcium signals the opening of plasma membrane calcium channels, has its roots in the late 1970's, and was formalized in 1986. This short introduction to the current volume of Frontiers in Bioscience briefly summarizes the early experimental work that ...
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The Physiological Function of Store-operated Calcium Entry [PDF]
Neurochemical Research, 2011 Store-operated Ca(2+) entry is a process whereby the depletion of intracellular Ca(2+) stores signals the opening of plasma membrane Ca(2+) channels. It has long been thought that the main function of store-operated Ca(2+) entry was the replenishment of intracellular Ca(2+) stores following their discharge during intracellular Ca(2+) signaling.
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Function, 2022 Cannabis sativa has long been known to affect numerous biological activities. Although plant extracts, purified cannabinoids, or synthetic cannabinoid analogs have shown therapeutic potential in pain, inflammation, seizure disorders, appetite stimulation,
Malika Faouzi +9 more
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Biological Research, 2019 Background Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats but the subcellular mechanism remains unclear.
Jinsen Lu +4 more
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Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
wiley +1 more source
Store‐operated calcium entry in vascular smooth muscle [PDF]
British Journal of Pharmacology, 2008 In non‐excitable cells, activation of G‐protein‐coupled phospholipase C (PLC)‐linked receptors causes the release of Ca2+from intracellular stores, which is followed by transmembrane Ca2+entry. This Ca2+entry underlies a small and sustained phase of the cellular [Ca2+]iincreases and is important for several cellular functions including gene expression,
F P, Leung +4 more
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