Results 71 to 80 of about 2,808,407 (277)

Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells. [PDF]

Many physiological functions, such as cell differentiation, proliferation, muscle contraction, neurotransmission and fertilisation, are regulated by changes of Ca2+ levels. The major Ca2+ store in cells is the endoplasmic reticulum (ER). Certain cellular
Dernič, Jan, Peinelt, Christine, Hediger, Matthias A, Bhardwaj, Rajesh, Lochner, Martin, Biner, Daniel, Tscherrig, Dominic, Ross-Kaschitza, Daniela   +7 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Immunodeficiency due to defects in store‐operated calcium entry [PDF]

Annals of the New York Academy of Sciences, 2011
Mutations in genes encoding the calcium‐release activated calcium (CRAC) channel abolish calcium influx in cells of the immune system and cause severe congenital immunodeficiency. Patients with autosomal recessive mutations in the CRAC channel gene ORAI1, its activator stromal interaction molecule 1 (STIM1), and mice with targeted deletion of Orai1 ...
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Exacerbated Skeletal Muscle Phenotype in Mice with ‘Homotypic’ Expression of the Tubular Aggregate Myopathy ORAI1 G100S Mutation

Biomedicines
Background: Tubular aggregate myopathy (TAM) is an autosomal dominant myopathy that results from gain-of-function mutations in the STIM1 and ORAI1 genes, which encode the two key proteins that coordinate store-operated Ca2+ entry in skeletal muscle and ...
Nan Zhao, Miao He, Robert T. Dirksen
doaj   +1 more source

Quetiapine inhibits microglial activation by neutralizing abnormal STIM1 mediated intercellular calcium homeostasis and promotes myelin repair in a cuprizone -induced mouse model of de-myelination

Frontiers in Cellular Neuroscience, 2015
Microglial activation has been considered as a crucial process in the pathogenesis of neuro-inflammation and psychiatric disorders. Several antipsychotic drugs have been shown to display inhibitory effects on microglial activation in vitro, possibly ...
Hanzhi eWang, Shubao eLiu, Yanping eTian, Xiyan eWu, Chengren eLi, Yangtao eHe, Michael eNamaka, Jiming eKong, Hongli eLi, Lan eXiao   +9 more
doaj   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation [PDF]

, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Ute Woelfle, Kristina Leuner, Schempp, Christoph M., Kraus, Margarethe, Walter E Müller, Harteneck Christian, Christoph M. Schempp, Walter E. Müller, Margarethe Kraus, Harteneck, Christian, Beschmann, Heike, Beschmann, Heike A., Boehncke, Wolf-Henning, Beschmann Heike, Boehncke Wolf-Henning, Schempp Christoph M., Kraus Margarethe, Christoph M Schempp, Schempp, Christoph Mathis, Wolf-Henning Boehncke, Heike Beschmann, Christian Harteneck, Woelfle Ute, Leuner Kristina, Leuner, Kristina, Wölfle, Ute, Müller Walter E., Woelfle, Ute, Müller, Walter E.   +28 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart

Biology Open, 2020
Store-operated Ca2+ entry (SOCE) is an essential Ca2+ signaling mechanism present in most animal cells. SOCE refers to Ca2+ influx that is activated by depletion of sarco/endoplasmic reticulum (S/ER) Ca2+ stores.
Courtney E. Petersen, Matthew J. Wolf, Jeremy T. Smyth   +2 more
doaj   +1 more source