Results 1 to 10 of about 6,046 (133)

Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening. [PDF]

Protein Sci
Abstract The calcium (Ca2+) channel Orai1—the pore‐forming subunit of the Ca2+ release‐activated Ca2+ channel—is opened by its physiological activator, the endoplasmic reticulum (ER)‐resident Ca2+ sensor stromal interaction molecule 1 (STIM1) upon ER Ca2+ store‐depletion.
Fröhlich M, Radišković T, Hopl V, Prantl M, Najjar H, Harant S, Thallinger D, Anwar MS, Horvath F, Söllner J, Nazarenko Y, Sallinger M, Müller N, Tiffner A, Weiß S, Grabmayr H, Krobath H, Derler I.   +17 more
europepmc   +2 more sources

Orai1-mediated Ca2+ entry regulates lipolysis and mitochondrial activation in brown adipose thermogenesis [PDF]

Experimental and Molecular Medicine
Cold-induced thermogenesis in brown adipose tissue is essential for maintaining energy homeostasis, yet the Ca2+-dependent mechanisms underlying this process remain incompletely understood.
Suji Kim, Phan Anh Nguyen, Kyu-Sang Park, Seung-Kuy Cha, Jun Namkung   +4 more
doaj   +2 more sources

Calcium Channel Protein ORAI1 Mediates TGF-β Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells

Frontiers in Oncology, 2021
Accumulating evidence suggested that calcium release-activated calcium modulator 1(ORAI1), a key calcium channel pore-forming protein-mediated store-operated Ca2+ entry (SOCE), is associated with human cancer. However, its role in colorectal cancer (CRC)
Qingjie Kang, Xudong Peng, Xiangshu Li, Denghua Hu, Guangxu Wen, Zhengqiang Wei, Baohong Yuan   +6 more
doaj   +3 more sources

Structural dynamics of the human Orai1 channel revealed by cryo-electron microscopy. [PDF]

PLoS ONE
The pore-forming Orai1 protein is an essential component of store-operated calcium entry (SOCE), a process vital to diverse cellular and physiological functions.
Yiming Zhang, Yuan Wang, Jindou Liu, Weiwei Bei, Hongkun Wang, Junli Wang, Lei Chen, Youjun Wang   +7 more
doaj   +2 more sources

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels

Function, 2021
To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca2+ nanodomain is a spatially confined signal that arises near open Ca2+ channels.
Pulak Kar, Pradeep Barak, Anna Zerio, Yu-Ping Lin, Amy J Parekh, Val J Watts, Dermot M F Cooper, Manuela Zaccolo, Holger Kramer, Anant B Parekh   +9 more
doaj   +1 more source

Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts

PLoS ONE, 2022
Despite exhibiting cardiotoxicity, doxorubicin (DOX) is widely used for cancer treatments. Cardiac fibroblasts (CFs) are important in the pathogenesis of heart failure. This necessitates the study of the effect of DOX on CFs.
Hiroko Nemoto, Masanari Umemura, Fumina Suzuki, Akane Nagasako, Kagemichi Nagao, Yuko Hidaka, Rina Nakakaji, Keiji Uchida, Shinichi Suzuki, Munetaka Masuda, Yoshihiro Ishikawa   +10 more
doaj   +2 more sources

Expression of Orai1 and STIM1 in human oral squamous cell carcinogenesis

Journal of Dental Sciences, 2022
Background/purpose: Return of Ca2+ to endoplasmic reticulum is mediated by Orai/STIM-mediated store-operated Ca2+ entry (SOCE) channel. We aimed to investigate Orai1 and STIM1 expressions in human oral carcinogenesis.
Yen-Yun Wang, Wen-Chen Wang, Chiang-Wei Su, Ching-Wei Hsu, Shyng-Shiou Yuan, Yuk-Kwan Chen   +5 more
doaj   +1 more source

BMP9 promotes bone differentiation of bone marrow mesenchymal stem cells via Orai1 pathway [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore the role of calcium release activated calcium channel protein 1 (Orai1) in bone marrow mesenchymal stem cells (BMSCs) osteogenesis induced by bone morphogenetic protein 9 (BMP9).
ZHOU Jia-wang, LU Guo-hai, LI Xiao-lin
doaj  

SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel

Physiological Reports, 2022
Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway ...
Tongde Wu, Alexandra S. Goriounova, Erin N. Worthington, Joe A. Wrennall, Arunava Ghosh, Saira Ahmad, M. Flori Sassano, Robert Tarran   +7 more
doaj   +1 more source

Rapid Upregulation of Orai1 Abundance in the Plasma Membrane of Platelets Following Activation with Thrombin and Collagen Related Peptide

Cellular Physiology and Biochemistry, 2015
Background: Blood platelets accomplish primary hemostasis following vascular injury and contribute to the orchestration of occlusive vascular disease. Platelets are activated by an increase of cytosolic Ca2+-activity ([Ca2+]i), which is accomplished by ...
Guilai Liu, Guoxing Liu, Hong Chen, Kousi Alzoubi, Anja T. Umbach, Meinrad Gawaz, Christos Stournaras, Florian Lang   +7 more
doaj   +1 more source