Results 11 to 20 of about 3,353,625 (210)
Short-term high-glucose treatment decreased abundance of Orai1 protein through posttranslational mechanisms in rat mesangial cells [PDF]
American Journal of Physiology - Renal Physiology, 2018 The short-term effect of high-glucose (HG) treatment on store-operated Ca2+entry in mesangial cells (MCs) is not well-known. The aim of the present study was to determine whether and how HG treatment for a short period altered protein abundance of Orai1, the channel mediating store-operated Ca2+entry in MCs. Rat and human MCs were exposed to HG (25 mM)
Sarika Chaudhari +2 more
exaly +5 more sources
NEFA-Sensitive Orai1 Expression in Regulation of De Novo Lipogenesis [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Non-esterified fatty acids (NEFAs) are important inducers of inflammatory responses and hepatic lipid accumulation, which lead to non-alcoholic fatty liver disease (NAFLD). High plasma NEFA is found in NAFLD patients, and associated with
Bingbing Zhang +7 more
doaj +3 more sources
Protein-protein interactions of TRPC3 and ORAI1
, 2011 Graz, Univ., Masterarb., 2011 ...
Jean-Quartier, Claire
core +4 more sources
Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells
Cellular Physiology and Biochemistry, 2016 Background: Chorein, a protein encoded by VPS13A (vacuolar protein sorting-associated protein 13A), is defective in chorea acanthocytosis, a rare disease characterized by acanthocytosis of red blood cells and neuronal cell death with progressive ...
Willi Yu +9 more
doaj +2 more sources
The FASEB Journal, 2015 The Orai1‐mediated store operated calcium entry (SOCE) is associated with many physiological and pathological processes in a variety of cells, including glomerular mesangial cells (MCs). We have previously demonstrated that prolonged treatment of MCs with high glucose (HG) significantly increased Orai1 expression at protein level, but not at mRNA level.
Sarika Chaudhari, Yanxia Wang, Rong Ma
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STIM proteins, Orai1, and gene expression [PDF]
Channels, 2013 Cytoplasmic Ca(2+) is an universal intracellular messenger that activates cellular responses over a broad temporal range, from neurotransmitter release to cell growth and proliferation. Inherent to the use of the multifarious Ca(2+) signal is the question of specificity: how can some Ca(2+)-dependent responses be activated in a cell and not others?
Pulak, Kar, Anant, Parekh
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Cross-linking of Orai1 channels by STIM proteins [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance The work presents a unique understanding of the organization and function of two ubiquitously expressed proteins, central in generating calcium signals in all cell types. These are the intracellular calcium sensing “STIM” proteins, and the highly selective cell surface “Orai” calcium channels. We reveal that STIM proteins
Yandong Zhou +9 more
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STIM1 Mutants Modify CRAC by Altering Orai1 Protein Concentration [PDF]
Biophysical Journal, 2012 The endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) binds and activates plasma membrane localized Orai1 channels, providing a Ca2+ influx pathway (store operated calcium entry, SOCE) that is essential for proper immune cell function.
Kilch, Tatiana +4 more
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Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma [PDF]
Molecular and Cellular Biology, 2015 The incidence of malignant melanoma, a cancer of the melanocyte cell lineage, has nearly doubled in the past 20 years. Wnt5A, akey driver of melanoma invasiveness, induces Ca2 signals. To understand how store-operated calcium entry (SOCE) contributes to Wnt5A-induced malignancy in melanoma models, we examined the expression and function of STIM1 and ...
Robert Hooper +9 more
openaire +2 more sources
STIM2 protein regulates Orai1-mediated store-operated Ca2+ entry in cardiomyocytes
Archives of Cardiovascular Diseases Supplements, 2021 Introduction Stromal interaction molecules, STIM1 and STIM2, are ER Ca2+ sensors that initiate store-operated Ca2+ entry (SOCE). It has been recently identified three STIM2 splice variants (STIM2.1, 2.2 and 2.3), STIM2.2 being SOCE activator whereas STIM2.1 will be SOCE inhibitor.
R. Luo +4 more
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