Results 41 to 50 of about 3,353,625 (210)

Ligustrazine suppresses platelet aggregation through inhibiting the activities of calcium sensors

Brazilian Journal of Pharmaceutical Sciences, 2022
Ligustrazine is widely used for the treatment of cardiovascular diseases in traditional Chinese medication. It has been reported that Ligustrazine decreases the concentration of intracellular calcium ions (Ca2+); however, the underlying mechanism remains
Shuibo Gao, Zhen Lei, Hong Wu
doaj   +1 more source

Lipid rafts determine association of Orai1, STIM1 and the TRPC1 and TRPC6 proteins

The FASEB Journal, 2010
Different laboratories have shown that proteins involved in Ca 2+ entry are localized in discrete plasma membrane lipid rafts, cholesterol and sphingolipid‐enriched membrane domains that scaffold certain signaling molecules while excluding ...
JUAN A ROSADO, CARMEN GALAN, GINES M SALIDO   +2 more
openaire   +1 more source

ORAI1 calcium channel orchestrates skin homeostasis [PDF]

, 2013
International audienceTo achieve and maintain skin architecture and homeostasis, keratinocytes must intricately balance growth, differentiation, and polarized motility known to be governed by calcium.
Vandenberghe, Matthieu, Raphaël, Maylis, Hastie, Ryan, Skryma, Roman, Hogan, Patrick, Lehen’kyi, V’yacheslav, Gordienko, Dmitri, Rao, Anjana, Oddos, Thierry, Prevarskaya, Natalia   +9 more
core   +1 more source

High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

Cell Death and Disease, 2021
Mitochondrial dysfunction and impaired Ca2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of phosphorylation, and the Orai1 (Ca2+ release-
Qing-Rui Wu, Dan-Lin Zheng, Pei-Ming Liu, Hui Yang, Lu-An Li, Su-Juan Kuang, Ying-Yu Lai, Fang Rao, Yu-Mei Xue, Ji-Jin Lin, Shuang-Xin Liu, Chun-Bo Chen, Chun-Yu Deng   +12 more
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Functional Role of STIM-1 and Orai1 in Human Microvascular Aging

Cells, 2022
The impact of aging on vascular function is heterogeneous depending on the vascular territories. Calcium regulation plays a key role in vascular function and has been implicated in aging-related hypercontractility of corpus cavernosum.
Mariam El Assar, Esther García-Rojo, Alejandro Sevilleja-Ortiz, Alberto Sánchez-Ferrer, Argentina Fernández, Borja García-Gómez, Javier Romero-Otero, Leocadio Rodríguez-Mañas, Javier Angulo   +8 more
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CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

Influence of smooth muscle contractility by inhibition of crac channels activity

European Pharmaceutical Journal, 2017
The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC
Kocmálová M., Kazimierová I.
doaj   +1 more source

A high-concentrate diet provokes inflammation, endoplasmic reticulum stress, and apoptosis in mammary tissue of dairy cows through the upregulation of STIM1/ORAI1

Journal of Dairy Science, 2022
: High-concentrate feeding can induce subacute ruminal acidosis, which leads to mammary tissue injury in dairy cows. Therefore, the purpose of this research was to evaluate the effect of high-concentrate feeding on STIM1 (stromal interaction molecule 1 ...
Meijuan Meng, Lairong Wang, Yan Wang, Nana Ma, Wan Xie, Guangjun Chang, Xiangzhen Shen   +6 more
doaj   +1 more source

Voltage Gating at the Selectivity Filter of the Ca2+ Release-activated Ca2+ Channel Induced by Mutation of the Orai1 Protein [PDF]

Journal of Biological Chemistry, 2008
The Ca(2+) release-activated Ca(2+) (CRAC) channel is a plasma membrane (PM) channel that is uniquely activated when free Ca(2+) level in the endoplasmic reticulum (ER) is substantially reduced. Several small interfering RNA screens identified two membrane proteins, Orai1 and STIM1, to be essential for the CRAC channel function.
Maria A, Spassova, Thamara, Hewavitharana, Richard A, Fandino, Asli, Kaya, Jacqueline, Tanaka, Donald L, Gill   +5 more
openaire   +2 more sources

Overexpression of SARAF Ameliorates Pressure Overload–Induced Cardiac Hypertrophy Through Suppressing STIM1-Orai1 in Mice

Cellular Physiology and Biochemistry, 2018
Background/Aims: Activation of stromal interaction molecule 1 (STIM1) and Orai1 participates in the development of cardiac hypertrophy. Store-operated Ca2+ entry-associated regulatory factor (SARAF) is an intrinsic inhibitor of STIM1-Orai1 interaction ...
Fengdan Dai, Yan Zhang, Qiang Wang, De Li, Yongjian Yang, Shuangtao Ma, Dachun Yang   +6 more
doaj   +1 more source