Results 51 to 60 of about 3,353,625 (210)

An Essential Role of STIM1, Orai1, and S100A8–A9 Proteins for Ca2+ Signaling and FcγR-Mediated Phagosomal Oxidative Activity [PDF]

The Journal of Immunology, 2011
Abstract Phagocytosis is a process of innate immunity that allows for the enclosure of pathogens within the phagosome and their subsequent destruction through the production of reactive oxygen species (ROS). Although these processes have been associated with increases of intracellular Ca2+ concentrations, the mechanisms by which Ca2 ...
Steinckwich, Natacha, SCHENTEN, Véronique, MELCHIOR, Chantal, BRÉCHARD, Sabrina, TSCHIRHART, Eric   +4 more
openaire   +3 more sources

Lithium Sensitive ORAI1 Expression, Store Operated Ca2+ Entry and Suicidal Death of Neurons in Chorea-Acanthocytosis

Scientific Reports, 2017
Chorea-Acanthocytosis (ChAc), a neurodegenerative disorder, results from loss-of-function-mutations of chorein-encoding gene VPS13A. In tumour cells chorein up-regulates ORAI1, a Ca2+-channel accomplishing store operated Ca2+-entry (SOCE) upon ...
Lisann Pelzl, Stefan Hauser, Bhaeldin Elsir, Basma Sukkar, Itishri Sahu, Yogesh Singh, Philip Höflinger, Rosi Bissinger, Mohamed Jemaà, Christos Stournaras, Ludger Schöls, Florian Lang   +11 more
doaj   +1 more source

Orai1 knockdown decreases HMGB1-induced permeability.

, 2015
A. Orai1 protein expression after RNA inference. EA.hy926 cells were transfected for 48 h with Orai1 siRNA-1, Orai1 siRNA-2 or control (scrambled) siRNA.
Chenzhong Li (725649), Shaoxi Cai (158124), Hangming Dong (725647), Mengchen Zou (725646), Yaoming Xue (488659), Xiaojing Meng (478101), Chunqing Cai (725648)   +6 more
core   +1 more source

The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes

Cell & Bioscience, 2020
Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the ...
Joice T. Gavali, Elba D. Carrillo, María C. García, Jorge A. Sánchez   +3 more
doaj   +1 more source

The purified extract of steamed Panax ginseng protects cardiomyocyte from ischemic injury via caveolin-1 phosphorylation-mediating calcium influx

Journal of Ginseng Research, 2023
Background: Caveolin-1, the scaffolding protein of cholesterol-rich invaginations, plays an important role in store-operated Ca2+ influx and its phosphorylation at Tyr14 (p-caveolin-1) is vital to mobilize protection against myocardial ischemia (MI ...
Hai-Xia Li, Yan Ma, Yu-Xiao Yan, Xin-Ke Zhai, Meng-Yu Xin, Tian Wang, Dong-Cao Xu, Yu-Tong Song, Chun-Dong Song, Cheng-Xue Pan   +9 more
doaj   +1 more source

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

eLife, 2023
Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor.
Priscilla S-W Yeung, Megumi Yamashita, Murali Prakriya   +2 more
doaj   +1 more source

Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells [PDF]

Journal of Biological Chemistry, 2016
Voltage-dependent CaV1.2 L-type Ca2+ channels (LTCC) are the main route for calcium entry in vascular smooth muscle cells (VSMC). Several studies have also determined the relevant role of store-operated Ca2+ channels (SOCC) in vascular tone regulation.
Ávila Medina, Javier, Calderón Sánchez, Eva María, González-Rodríguez, Patricia, Monje Quiroga, Francisco, Rosado, Juan Antonio, Castellano Orozco, Antonio Gonzalo, Ordóñez Fernández, José Antonio, Smani Hajami, Tarik   +7 more
openaire   +5 more sources

ORAI1 mutations abolishing store-operated Ca

, 2018
BACKGROUND: Store-operated Ca OBJECTIVE: We performed molecular and immunologic analysis of patients with CID, anhidrosis, and ectodermal dysplasia of unknown etiology.
Issekutz, Thomas, Cuk, Mario, Karmen Bilic, Ehl, Stephan, Jayson Lian, Frédéric Rieux-Laucat, Kacskovics, Imre, Peter Stathopulos, Stephan Ehl, Imre Kacskovics, Vraetz, Thomas, Speckmann, Carsten, Feske, Stefan, Lina Kozhaya, Unutmaz, Derya, Lian, Jayson, Stathopulos, Peter, Melina J. Benson, Antonia Jakovcevic, Mario Cuk, Capucine Picard, Stefan Feske, Sascha Kahlfuss, Kahlfuss, Sascha, Jakovcevic, Antonia, Thomas Issekutz, Kozhaya, Lina, Carsten Speckmann, Thomas Vraetz, Benson, Melina J, Iva Martinac, Rieux-Laucat, Frédéric, Martinac, Iva, Vaeth, Martin, Martin Vaeth, Bilic, Karmen, Derya Unutmaz, Picard, Capucine   +37 more
core   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin

Cellular Physiology and Biochemistry, 2018
Background/Aims: The neurodegenerative disease Chorea-Acanthocytosis (ChAc) is caused by loss-of-function-mutations of the chorein-encoding gene VPS13A.
Basma Sukkar, Stefan Hauser, Lisann Pelzl, Zohreh Hosseinzadeh, Itishri Sahu, Tamer al-Maghout, Abdulla Al Mamun Bhuyan, Nefeli Zacharopoulou, Christos Stournaras, Ludger Schöls, Florian Lang   +10 more
doaj   +1 more source