Results 31 to 40 of about 3,353,625 (210)
Kidney & Blood Pressure Research, 2014 Background/Aims: Mineralocorticoid excess leads to vascular injury, which is partially due to hypertension but in addition involves increased concentration of cytosolic Ca2+ concentration in platelets, key players in the pathophysiology of occlusive ...
Guoxing Liu +7 more
doaj +1 more source
The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis
Scientific Reports, 2021 Regulation of Ca2+ signaling is critical for the progression of cell division, especially during meiosis to prepare the egg for fertilization. The primary Ca2+ influx pathway in oocytes is Store-Operated Ca2+ Entry (SOCE).
Rawad Hodeify +9 more
doaj +1 more source
环境与职业医学, 2022 BackgroundIt has been found that fluoride may cause cell damage by inducing intracellular calcium overload. Store-operated calcium entry (SOCE) plays an important role in maintaining intracellular calcium homeostasis, but the effect of fluoride on renal ...
Xuan WU, Fan DING, Yingying LIU, Qing WU
doaj +1 more source
Sequential Steps of CRAC Channel Activation
Cell Reports, 2017 Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. How STIM1 binds and activates ORAI1 remains poorly understood.
Raz Palty, Zhu Fu, Ehud Y. Isacoff
doaj +1 more source
Overexpression of Orai1 and STIM1 Proteins Alters Regulation of Store-operated Ca2+ Entry by Endogenous Mediators [PDF]
Journal of Biological Chemistry, 2012 Orai1 and STIM1 have been identified as the main determinants of the store-operated Ca(2+) entry (SOCE). Their specific roles in SOCE and their molecular interactions have been studied extensively following heterologous overexpression or molecular knockdown and extrapolated to the endogenous processes in naïve cells.
Tomasz, Gwozdz +3 more
openaire +2 more sources
Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry. [PDF]
, 2016 N-glycosylation of cell surface proteins affects protein function, stability, and interaction with other proteins. Orai channels, which mediate store-operated Ca(2+) entry (SOCE), are composed of N-glycosylated subunits.
Kappel, Sven +6 more
core +1 more source
Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. [PDF]
PLoS ONE, 2011 The interaction between Ca(2+) sensors STIM1 and STIM2 and Ca(2+) channel-forming protein ORAI1 is a crucial element of store-operated calcium entry (SOCE) in non-excitable cells. However, the molecular mechanism of SOCE in neurons remains unclear.
Joanna Gruszczynska-Biegala +3 more
doaj +1 more source
Cells, 2021 Store-operated calcium entry (SOCE) provided through channels formed by ORAI proteins is a major regulator of several cellular processes. In immune cells, it controls fundamental processes such as proliferation, cell adhesion, and migration, while in ...
Alexandre Bokhobza +4 more
doaj +1 more source
Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function. [PDF]
PLoS ONE, 2013 Despite the attractiveness of ion channels as therapeutic targets, there are no examples of monoclonal antibodies directed against ion channels in clinical development.
Jennifer H Cox +13 more
doaj +1 more source
Store-operated calcium entry and the localization of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells [PDF]
Frontiers in Physiology, 2015 In many non-excitable and excitable cells, store-operated calcium entry (SOCE) represents an additional pathway for calcium entry upon Ca(2+) store depletion. In a previous study, we demonstrated SOCE activity in intact mouse cardiac pacemaker tissue, specifically from sinoatrial node (SAN) tissue.
Liu, Jie +4 more
openaire +3 more sources