Results 21 to 30 of about 3,353,625 (210)
Detecting single ORAI1 proteins within the plasma membrane reveals higher-order channel complexes [PDF]
Journal of Cell Science, 2020 ABSTRACT ORAI1 proteins form highly selective Ca2+ channels in the plasma membrane. Crystallographic data point towards a hexameric stoichiometry of ORAI1 channels, whereas optical methods postulated ORAI1 channels to reside as dimers at rest, and other data suggests that they have a tetrameric configuration.
Dalia Alansary +3 more
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Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
, 2022 Orai1, the first identified member of the Orai protein family, is ubiquitously expressed in the animal kingdom. Orai1 was initially characterized as the channel responsible for the store-operated calcium entry (SOCE), a major mechanism that allows ...
Nieto-Felipe, Joel +15 more
core +1 more source
The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry. [PDF]
, 2021 To avoid conflicting and deleterious outcomes, eukaryotic cells often confine second messengers to spatially restricted subcompartments. The smallest signaling unit is the Ca2+ nanodomain, which forms when Ca2+ channels open.
Kar, Pulak +8 more
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Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source
Oncogenesis, 2022 As an important second messenger, calcium (Ca2+) regulates a wide variety of physiological processes. Disturbance of intracellular calcium homeostasis implicated in the occurrence of multiple types of diseases.
Chunming Gu +9 more
doaj +1 more source
Orai1 Boosts SK3 Channel Activation
, 2021 The interplay of SK3, a Ca2+ sensitive K+ ion channel, with Orai1, a Ca2+ ion channel, has been reported to increase cytosolic Ca2+ levels, thereby triggering proliferation of breast and colon cancer cells, although a molecular mechanism has remained ...
Adéla Tiffner +14 more
core +1 more source
The Journal of Physiology, 2009 Two cellular proteins, stromal interaction molecule 1 (STIM1) and Orai1, are recently discovered essential components of the Ca2+ release activated Ca2+ (CRAC) channel. Orai1 polypeptides form the pore of the CRAC channel, while STIM1 plays the role of the endoplasmic reticulum Ca2+ sensor required for activation of CRAC current (ICRAC) by store ...
Ma, LinLin +4 more
openaire +6 more sources
Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins. [PDF]
Cellular microbiology, 2012 Streptolysin O (SLO) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pyogenes. SLO induces diverse types of Ca(2+) signalling in host cells which play a key role in membrane repair and cell fate determination. The mechanisms behind SLO-induced Ca(2+) signalling remain poorly understood.
Shariq M, Usmani +7 more
openaire +2 more sources
Key Components of Store-Operated Ca2+ Entry in Non-Excitable Cells
Journal of Pharmacological Sciences, 2014 .: Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ entry pathway in non-excitable cells. It is activated by the depletion of Ca2+ from intracellular Ca2+ stores, notably the endoplasmic reticulum (ER).
Yosuke Tojyo +3 more
doaj +1 more source
STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions
Cell Reports, 2018 Summary: Ca2+ entry mediated by the calcium channel, Orai1, provides critical Ca2+ signals that regulate cell function. The ER-Ca2+ sensor protein, STIM1, recruits and strongly activates Orai1 within ER-PM junctions.
Krishna Prasad Subedi +4 more
doaj +1 more source