Results 71 to 80 of about 3,353,625 (210)
α-SNAP binds to the hinge region near the Orai1 C-terminus.
, 2021 (A)In vitro binding of α-SNAP to MBP-tagged Orai1 C-terminus 228–301 and its subdomains, Orai1 245–272 and Orai1 272–292. (Top) Ponceau S staining showing the input of MBP-tagged fragments.
Yong Miao (380871) +2 more
core +1 more source
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, Volume 74, Issue S1, Page S58-S64, September 2026.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
Sestrin2 interacts and regulates Orai1 calcium channels [PDF]
, 2020 Department of Biological SciencesStore-operated Ca2+ entry (SOCE) is based on the interaction of endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) with the Orai1 Ca2+ channel which is located in plasma membrane.
Jang, Ki Hyun
core
Journal of Extracellular Vesicles, 2022 Blockade of immune checkpoints as a strategy of cancer cells to overcome the immune response has received ample attention in cancer research recently.
Xi Chen +10 more
doaj +1 more source
FASEB BioAdvances, Volume 8, Issue 9, September 2026.Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Praghalathan Kanthakumar +1 more
wiley +1 more source
Mutations of the ca(2+)-sensing stromal interaction molecule stim1 regulate ca(2+) influx by altered oligomerization of stim1 and by destabilization of the ca(2+) channel orai1 [PDF]
, 2013 A drop of endoplasmic reticulum Ca²⁺ concentration triggers its Ca²⁺ ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize and accumulate within endoplasmic reticulum-plasma membrane junctions where it activates Orai1 channels, providing ...
Rychkov, G. +15 more
core +1 more source
α-SNAP binds a membrane proximal region of Orai1 N-terminus.
, 2021 (A)In vitro binding of α-SNAP to MBP-tagged Orai1 N-terminus 1–103 and its subdomains, Orai1 1–47 and Orai1 48–103. (Top) Ponceau S staining showing the input of MBP-tagged Orai1-N terminus fragments.
Yong Miao (380871) +2 more
core +1 more source
Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3. [PDF]
PLoS ONE, 2014 Dendritic cells (DCs), key players of immunity, are regulated by glycogen synthase kinase GSK3. GSK3 activity is suppressed by PKB/Akt and SGK isoforms, which are in turn stimulated by the PI3K pathway. Exposure to bacterial lipopolysaccharides increases
Evi Schmid +7 more
doaj +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Effects of GSK3 inhibitor SB216763 on Orai1, STIM1, and STIM2 protein abundance in DCs.
, 2014 A. Original western blot showing the protein abundance of Orai1 and respective GAPDH, STIM1 and respective GAPDH, STIM2 and respective GAPDH in DCs without (control) and with SB216763 treatment (1 µM, 4–24 h).
Florian Lang (176272) +7 more
core +1 more source