Results 91 to 100 of about 3,353,625 (210)
European Journal of Immunology, Volume 56, Issue 7, July 2026.Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Chandi Tabeth Magawa +3 more
wiley +1 more source
STIM1 and Orai1 are expressed and functional in 16HBE cells.
, 2014 A–B, Western blots show the presence of STIM1 (A) and STIM2 (B) in 16HBE lysates. Aggregate data from 3 independent experiments are shown in B. C, RT-PCR reveals the presence of Orai transcripts. D, Averaged data are compared.
Daniel Bakowski (621895) +2 more
core +1 more source
Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p
Frontiers in Immunology, 2019 The gut microbiota influences several biological functions including immune responses. Inflammatory bowel disease is favorably influenced by consumption of several dietary natural plant products such as pomegranate, walnuts, and berries containing ...
Shaqiu Zhang +11 more
doaj +1 more source
Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity
Pulmonary Circulation, Volume 16, Issue 3, July 2026.ABSTRACT Mechanosensitive cation channels expressed in pulmonary arterial smooth muscle (SMC) and endothelial (EC) cells contribute to the regulation of vasoconstriction and vasodilation of the pulmonary vasculature. Here, we report that activating Piezo1, a mechanosensitive cation channel, with Yoda1 induced a mild increase in pulmonary arterial ...
Sophia Parmisano +17 more
wiley +1 more source
cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells [PDF]
Journal of Biological Chemistry, 2012 The events leading to the activation of store-operated Ca(2+) entry (SOCE) involve Ca(2+) depletion of the endoplasmic reticulum (ER) resulting in translocation of the transmembrane Ca(2+) sensor protein, stromal interaction molecule 1 (STIM1), to the junctions between ER and the plasma membrane where it binds to the Ca(2+) channel protein Orai1 to ...
Tian, Geng +3 more
openaire +3 more sources
Orai1 mediates exacerbated Ca(2+) entry in dystrophic skeletal muscle. [PDF]
PLoS ONE, 2012 There is substantial evidence indicating that disruption of Ca(2+) homeostasis and activation of cytosolic proteases play a key role in the pathogenesis and progression of Duchenne Muscular Dystrophy (DMD).
Xiaoli Zhao +4 more
doaj +1 more source
Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem +2 more
wiley +1 more source
CD95 triggers Orai1-mediated localized Ca 2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation [PDF]
Proceedings of the National Academy of Sciences, 2011 The death receptor CD95 plays a pivotal role in immune surveillance and immune tolerance. Binding of CD95L to CD95 leads to recruitment of the adaptor protein Fas-associated death domain protein (FADD), which in turn aggregates caspase-8 and caspase-10.
Khadra, Nadine +12 more
openaire +2 more sources
Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]
, 2018 Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias +5 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source