Results 101 to 110 of about 3,353,625 (210)

A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

eLife, 2020
Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 ...
Priscilla S-W Yeung, Christopher E Ing, Megumi Yamashita, Régis Pomès, Murali Prakriya   +4 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Ryanodine Receptor Ca2+ Leak‐Induced Redistribution of Ca2+ in Dystrophic mdx Mouse Muscle

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The dystrophic mdx mouse is a widely used model of Duchenne muscular dystrophy. Altered Ca2+ handling is a key feature, including increased Ca2+ leak through the ryanodine receptor (RyR1's), the primary Ca2+ release channel in skeletal muscle. Such leak has important downstream consequences for intracellular Ca2+ homeostasis.
Rhayanna B. Gaglianone, Cedric R. Lamboley, Taylor Dick, Aldo Meizoso‐Huesca, Daniel P. Singh, Bradley S. Launikonis   +5 more
wiley   +1 more source

Up-regulation of Orai1 in mdx muscle.

, 2012
(A) mRNA expression levels of Orai1 and STIM1 in gastrocnemius muscles from wt C57BL/10ScSnJ and dystrophic C57BL/10ScSn-Dmdmdx/J mice were detected by real-time PCR.
Sai Zhang (118714), Shinji Komazaki (118718), Xiaoli Zhao (118708), Joseph G. Moloughney (118711), Noah Weisleder (118722)   +4 more
core   +1 more source

Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Components and properties of Ca2+ buffers in astrocytes, which should be considered for data interpretation and in computational modeling of astrocyte Ca2+ activity. ABSTRACT Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis.
Kerstin Lenk, Andre Zeug, Franziska E. Müller   +2 more
wiley   +1 more source

ORAI1, FGF23, PP13, palladin, and supervillin as potential biomarkers in late-onset pre-eclampsia: a comparative study in maternal and cord blood

BMC Pregnancy and Childbirth
Background Pre-eclampsia continues to be a significant global health burden with complex pathophysiology, necessitating investigation of novel biomarkers to improve understanding, diagnosis and management of this pregnancy-specific disorder.To ...
Hatice Argun Atalmis, Sinem Tekin, Ibrahim Yilmaz, Emine Yilmaz Guler, Filiz Yarsilikal Guleroglu, Ali Cetin   +5 more
doaj   +1 more source

Expressed protein ligation for a large dimeric protein [PDF]

, 2011
Expressed protein ligation (EPL) is a protein engineering tool for post-translational ligation of protein or peptide fragments. This technique allows modification of specific parts of proteins, opening possibilities for incorporating probes for ...
NMR Spectroscopy, Karagöz, G.E., Sub Cellular Protein Chemistry, O. Hsieh, Sub NMR Spectroscopy, T. Sinnige, Rüdiger, S.G.D., Hsieh, O., Sinnige, T, G. E. Karagoz, S. G. D. Rudiger, Cellular Protein Chemistry   +11 more
core   +1 more source

Amplification of CRAC current by STIM1 and CRACM1 (Orai1). [PDF]

, 2006
Depletion of intracellular calcium stores activates store-operated calcium entry across the plasma membrane in many cells. STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (
Koomoa, Dana L, Fleig, Andrea, Peinelt, Christine, Nadler, Monica J S, Murielle Koblan-Huberson, Lis, Annette, Andrea Fleig, Penner, Reinhold, Christine Peinelt, Kinet, Jean-Pierre, Andreas Beck, Monica J. S. Nadler, Annette Lis, Reinhold Penner, Dana L. Koomoa, Jean-Pierre Kinet, Vig, Monika, Beck, Andreas, Monika Vig, Koblan-Huberson, Murielle   +19 more
core   +1 more source

Store-Operated Calcium Channels Contribute to Remifentanil-Induced Postoperative Hyperalgesia via Phosphorylation of CaMKIIα in Rats

Journal of Pain Research, 2021
Zhenhui Zhou,1,* Meng Mao,2,* Xuechun Cai,1 Wei Zhu,1 Jie Sun3 1Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Department of ...
Zhou Z, Mao M, Cai X, Zhu W, Sun J
doaj  

Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels, Orai1 and TRPV3

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To examine the effects of Tribulus terrestris L. (T. terrestris) extract on the modulation of calcium channels to evaluate its use in topical agents for treatment of atopic dermatitis. Methods: The 70% methanol extract of T.
Joo Hyun Nam, Hyo Won Jung, Young-Won Chin, Woo Kyung Kim, Hyo Sang Bae   +4 more
doaj   +1 more source