Results 121 to 130 of about 3,353,625 (210)

Viral subversion of host cell Ca²⁺ signaling through STIM1-Orai1-mediated SOCE: Mechanisms and implications

Pharmacological Research
Viral infection hijacks host cell physiological processes to replicate and spread, in which the calcium ion (Ca2 +) signaling pathway plays a key role in the viral life cycle.
Qingqing Lu, Yuan Ding, Yan Zhang, Shuzhen Liu   +3 more
doaj   +1 more source

PROLONGED HIGH GLUCOSE TREATMENT INCREASED STIM1/ORAI1 PROTEIN EXPRESSION AND ENHANCED STORE-OPERATED CA2+ ENTRY IN HUMAN GLOMERULAR MESANGIAL CELLS

, 2013
Purpose: Stromal interaction molecule1 (STIM1) and Orai1 regulate intracellular Ca2+ signaling via store operated Ca2+ entry (SOCE). Our previous study demonstrated that STIM1 is required for SOCE in human mesangial cells (HMC) of kidneys.
Chaudhari, Sarika
core  

Generation of specific anti-human Orai1 monoclonal antibody.

, 2013
A) Representation of human Orai1 tetra-membrane spanning protein with two extracellular loops of approximately 20 and 40 amino acids, respectively. B) Titration of purified monoclonal anti-Orai1 antibody binding to loop 2 peptide in ELISA assay. C) Ba/F3
John-Vu Bui (501562), Jun Zhang (48506), Stefan Zahn (501567), Henrik Søndergaard (203225), Jennifer H. Cox (379107), Claus Haase (501566), Jen Running Deer (501563), Kirstine Roepstorff (501561), Zhan-Guo Li (309607), Kasper Lamberth (78383), Peter Helding Kvist (501564), Søren Padkjær (501565), Scott Hussell (501560), Valerie H. Odegard (501568)   +13 more
core   +1 more source

STIM Proteins Cluster Orai1 Channels and Modulate Receptor-Mediated Calcium Signals [PDF]

Biophysical Journal, 2018
Robert M. Nwokonko, Yandong Zhou, Xiangyu Cai, Natalia Loktionova, Mohamed Trebak, Donald L. Gill   +5 more
openaire   +1 more source

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

, 2010
et al.Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca2+) entry through plasma membrane Orai1 channels in response to decreased Ca2+ concentrations in the endoplasmic reticulum lumen. We identified an acidic motif within the STIM1 coiled-
Manjarrés, Isabel M., Korzeniowski, Marek K.   +1 more
core   +1 more source

Functional analysis of Orai1 using unnatural amino acids

, 2019
Calcium ions (Ca2+) are important key players in a healthy, functional cell. Their entry is mediated by Ca2+ ion channels of which the most prominent one is the calcium released-activated calcium (CRAC) channel.
Leopold, Melanie
core   +1 more source

Orai1-Mediated I _CRAC Is Essential for Neointima Formation After Vascular Injury

, 2011
Rationale: The molecular correlate of the calcium release-activated calcium current ( I CRAC ), the channel ...
Wei Zhang, Katharine E. Halligan, Khalid Matrougui, Peter A. Vincent, Margarida Barroso, Rajender K. Motiani, Guoqing Hu, Xuexin Zhang, Jiliang Zhou, Harold A. Singer, Mohamed Trebak, Jonathan M. Bisaillon, José C. Gonzalez-Cobos   +12 more
core   +1 more source

Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish. [PDF]

, 2012
Mutations in the store-operated Ca²⁺ entry pore protein ORAI1 have been reported to cause myopathies in human patients but the mechanism involved is not known. Cardiomyocytes express ORAI1 but its role in heart function is also unknown.
Völkers, Mirko, Most, Patrick, Sussman, Mark A, Gude, Natalie, Hassel, David, Dolatabadi, Nima   +5 more
core  

Potassium channel KCa2.3 (KCNN3; SK3); transmembrane protein 142A (ORAI1; TMEM142A; CRACM1) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases. [PDF]

Channels (Austin)
Liao X, Pan C, Guo X, Cheng J.
europepmc   +1 more source