Results 111 to 120 of about 3,353,625 (210)

Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]

, 2012
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V., Sub Cellular Protein Chemistry, Sebera, J., Tanaka, Y., Trantirek, L., Cellular Protein Chemistry   +5 more
core   +1 more source

Picky Hsp90-Every Game with Another Mate [PDF]

, 2017
In this issue of Molecular Cell, Sahasrabudhe et al. (2017) present a dramatically renovated functional cycle for the molecular chaperone Hsp90, which stimulates re-thinking of the mechanism of this vital protein folding ...
Sub Cellular Protein Chemistry, Rüdiger, Stefan G D, Radli, Martina, Cellular Protein Chemistry   +3 more
core   +2 more sources

Pregnancy-Specific Beta-1-Glycoprotein 1 Increases HTR-8/SVneo Cell Migration through the Orai1/Akt Signaling Pathway

Biomolecules
The impaired invasion ability of trophoblast cells is related to the occurrence of preeclampsia (PE). We previously found that pregnancy-specific beta-1-glycoprotein 1 (PSG1) levels were decreased in the serum of individuals with early-onset preeclampsia
Qunhua Wang, Yan Fang, Yuan Li, Huali Liu, Maoni Zhu, Xue Hu, Jinzhuo Zhou, Anqi Deng, Bing Shen, Hongbo Chen   +9 more
doaj   +1 more source

Toward a Model for Activation of Orai Channel

iScience, 2019
Summary: Store-operated calcium release-activated calcium (CRAC) channels mediate a variety of cellular signaling functions. The CRAC channel pore-forming protein, Orai1, is a hexamer arranged with 3-fold symmetry.
Hao Dong, Yiming Zhang, Ruiheng Song, Jingjie Xu, Yigao Yuan, Jindou Liu, Jia Li, Sisi Zheng, Tiantian Liu, Benzhuo Lu, Youjun Wang, Michael L. Klein   +11 more
doaj   +1 more source

Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1. [PDF]

, 2014
NFAT-dependent gene expression is essential for the development and function of the nervous, immune, and cardiovascular systems and kidney, bone, and skeletal muscle.
Samanta, K, Kar, Pulak, Kar, P, Kramer, H, Morris, Otto, Morris, O, Bakowski, D, Parekh, Anant B., Samanta, Krishna, Bakowski, Daniel, Parekh, AB, Parekh, Anant, Kramer, Holger   +12 more
core   +1 more source

Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Istaroxime is a validated inotropic Na+/K+ ATPase inhibitor currently in development for the treatment of various cardiac conditions. Recent findings established that this steroidal drug exhibits potent apoptotic responses in prostate ...
Matias Julian Stagno, Nefeli Zacharopoulou, Jonas Bochem, Anna Tsapara, Lisann Pelzl, Tamer al-Maghout, Galatea Kallergi, Saad Alkahtani, Konstantinos Alevizopoulos, Konstantinos Dimas, Theodora Calogeropoulou, Steven W. Warmann, Florian Lang, Evi Schmid, Christos Stournaras   +14 more
doaj   +1 more source

Suppressed ORAI1-STIM1-dependent Ca2+ entry by protein kinase C isoforms regulating platelet procoagulant activity

Journal of Biological Chemistry
Agonist-induced rises in cytosolic Ca2+ control most platelet responses in thrombosis and hemostasis. In human platelets, we earlier demonstrated that the ORAI1-STIM1 pathway is a major component of extracellular Ca2+ entry, in particular when induced via the ITAM-linked collagen receptor, glycoprotein VI (GPVI).
Jinmi Zou, Pengyu Zhang, Fiorella A. Solari, Claudia Schönichen, Isabella Provenzale, Nadine J.A. Mattheij, Marijke J.E. Kuijpers, Julia S. Rauch, Frauke Swieringa, Albert Sickmann, Barbara Zieger, Kerstin Jurk, Johan W.M. Heemskerk   +12 more
openaire   +3 more sources

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

Orai1 Expression and Vascular Function in Kidney Donors Determine Graft Outcomes at Short/Mid-Term

Cells
We aimed to determine the influence of donors’ vascular function on renal function in recipients and to evaluate the role of Orai1 calcium channels as a potential marker. A prospective collaborative multicenter study was designed.
Esther García-Rojo, Javier Angulo, Mariam El Assar, Rocío Santos-Pérez de la Blanca, Borja García-Gómez, José Medina-Polo, Alejandro Sevilleja-Ortiz, Leocadio Rodríguez-Mañas, Argentina Fernández, Eduardo Gutiérrez-Martínez, Enrique Morales-Ruiz, Alfredo Rodríguez-Antolín, Javier Romero-Otero   +12 more
doaj   +1 more source

Hydrogen peroxide disrupts the regulatory pathway of saliva secretion in two salivary acinar rat cell lines

Frontiers in Molecular Biosciences
BackgroundSecretion of saliva is controlled by autonomic nerve signals via regulation of Ca2+-dependent ion transport across acinar cell membranes. Oxidative stress may affect this process, leading to a decrease in saliva production.
Golnaz Golnarnik, Tine M. Søland, Hilde K. Galtung, Trude M. Haug   +3 more
doaj   +1 more source