Results 81 to 90 of about 3,353,625 (210)
Cellular Physiology and Biochemistry, 2018 Background/Aims: Upon Ca2+ store depletion, stromal interaction molecule 1 (STIM1) oligomerizes, redistributes near plasmalemma to interact with Ca2+ selective channel-forming subunit (Orai1) and initiates store-operated Ca2+ entry (SOCE).
Shu Li +9 more
doaj +1 more source
Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1. [PDF]
PLoS ONE, 2016 Using the systematic evolution of ligands by exponential enrichment (SELEX) method, we identified oligonucleotides that bind to the first extracellular domain of the Orai1 protein with high affinities and high specificities.
Renshan Sun +3 more
doaj +1 more source
Role of the store‐operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor‐stimulated calcium oscillations in human embryonic kidney cells [PDF]
The Journal of Physiology, 2007 We have investigated the nature of the Ca2+ entry supporting [Ca2+]i oscillations in human embryonic kidney (HEK293) cells by examining the roles of recently described store‐operated Ca2+ entry proteins, Stim1 and Orai1. Knockdown of Stim1 by RNA interference (RNAi) reduced the frequency of [Ca2+]i oscillations in response to a low concentration of ...
Barbara, Wedel +3 more
openaire +2 more sources
Effects of GSK3 inhibitor GSK-XIII on Orai1, STIM1, and STIM2 protein abundance in DCs.
, 2014 A. Original western blot showing the protein abundance of Orai1, STIM2 and respective GAPDH, STIM1 and respective GAPDH, in DCs without (control) and with GSK-XIII treatment (10 µM, 4–24 h).
Florian Lang (176272) +7 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Chronic neuroinflammation in Alzheimer's disease (AD) alters astrocyte physiology and neurovascular unit function. AD patients frequently experience recurrent systemic inflammatory insults from comorbid conditions, which act as “secondary‐hits” believed to worsen cognitive decline.
Chang Liu +4 more
wiley +1 more source
Single-nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression [PDF]
Human Molecular Genetics, 2019 AbstractLoss-of function mutations in Orai1 Ca2+ channels lead to a form of severe combined immunodeficiency, auto-immunity, muscle hypotonia and defects in dental enamel production and sweat gland function. Two single-nucleotide polymorphisms (SNPs) in Orai1 have been found and localize to the second extracellular loop.
Yeh, Y-C +3 more
openaire +2 more sources
Expression of STIM1, STIM2, and Orai1.
, 2013 A: Expression of STIM1, STIM2, Orai1, and GAPDH mRNAs detected by RT-PCR in human airway smooth muscle (ASM) cells is shown. Negative indicates a negative control.
Satoru Ito (283410) +6 more
core +1 more source
Characterisation and structural investigation of disease-related Orai1-T184 mutants
, 2020 Cations, especially calcium (Ca2+), play important roles in many biological processes. Gene regulation, immune defence as well as cell growth and death are initiated and regulated by the entry and release of Ca2+ in excitable and non-excitable cells. The
Sallinger, Matthias
core +2 more sources
Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1338-1352, July 2026.Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan +6 more
wiley +1 more source