Regulation of store-operated calcium entry [PDF]
, 2023 Plasma membrane calcium influx through ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP3), which binds to IP3 receptors in the endoplasmic reticulum (ER) to release calcium pools from the ER lumen.
Kodakandla, Goutham +2 more
core +4 more sources
Sulfhydryl modification induces calcium entry through IP₃-sensitive store-operated pathway in activation-dependent human neutrophils. [PDF]
PLoS ONE, 2011 As the first line of host defense, neutrophils are stimulated by pro-inflammatory cytokines from resting state, facilitating the execution of immunomodulatory functions in activation state.
Leiting Pan +6 more
doaj +3 more sources
Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry [PDF]
Cell Reports, 2020 Summary: Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls cellular redox signaling and is itself regulated by redox modifications.
Christine Silvia Gibhardt +26 more
doaj +5 more sources
Astrocyte store-operated calcium entry is required for centrally mediated neuropathic pain [PDF]
PAIN Reports. Introduction:. Acute injuries transition to chronic neuropathic pain through central sensitization (CS), which involves plastic changes to nociceptive networks within the central nervous system.
Mariya A. Prokhorenko, Jeremy T. Smyth
doaj +2 more sources
Frontiers in Physiology, 2018 Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen +4 more
doaj +3 more sources
Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm [PDF]
BiomoleculesAbdominal aortic aneurysm (AAA) is a life-threatening vascular disease characterized by vascular smooth muscle cell (VSMC) dysfunction and disrupted calcium homeostasis.
Yi-Qian Wang +7 more
doaj +2 more sources
CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A. [PDF]
PLoS ONE, 2018 The Chloride Channel Accessory (CLCA) protein family was first characterized as regulators of calcium-activated chloride channel (CaCC) currents (ICaCC), but the mechanism has not been fully established. We hypothesized that CLCAs might regulate ICaCC by
Aarushi Sharma +4 more
doaj +2 more sources
Remodelling of the endoplasmic reticulum during store‐operated calcium entry [PDF]
Biology of the Cell, 2011 SOCE (store‐operated calcium entry) is a ubiquitous cellular mechanism linking the calcium depletion of the ER (endoplasmic reticulum) to the activation of PM (plasma membrane) Ca2+‐permeable channels. The activation of SOCE channels favours the entry of extracellular Ca2+ into the cytosol, thereby promoting the refilling of the depleted ER Ca2+ stores
Shen, Weiwei +2 more
openaire +5 more sources
Store-operated calcium entry in human spermatozoa [PDF]
, 2012 The contribution of store-operated calcium entry (SOCE) in the response of human sperm to progesterone, a steroid secreted from the cumulus cells surrounding the oocyte, has not yet been elucidated.
Nash, Katherine Louise
core +7 more sources
Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids [PDF]
Function, 2022 J Ashot Kozak
doaj +2 more sources