Results 11 to 20 of about 11,100 (249)
STIM and Orai1 variants in store-operated calcium entry [PDF]
Frontiers in Pharmacology, 2016 Store-operated Ca2+ is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the STIM ...
JUAN ANTONIO ROSADO +3 more
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Store-operated calcium entry in neuroglia [PDF]
Neuroscience Bulletin, 2013 Neuroglial cells are homeostatic neural cells. Generally, they are electrically non-excitable and their activation is associated with the generation of complex intracellular Ca(2+) signals that define the "Ca(2+) excitability" of glia. In mammalian glial cells the major source of Ca(2+) for this excitability is the lumen of the endoplasmic reticulum ...
Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898 +1 more
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Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
eLife, 2021 The dimeric ER Ca2+ sensor STIM1 controls store-operated Ca2+ entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane.
Stijn van Dorp +7 more
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Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
Cells, 2021 Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
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Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer
Frontiers in Pharmacology, 2021 Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells, and regulates a variety of cellular functions including proliferation, motility, apoptosis, and death.
Xiaojing Liang +5 more
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Store-operated calcium entry and diabetic complications [PDF]
Experimental Biology and Medicine, 2015 Store-operated Ca 2+ entry (SOCE) is mediated by the store-operated Ca 2+ channel (SOC) that opens upon depletion of internal Ca 2+ stores following activation of G protein-coupled receptors or receptor tyrosine ...
Sarika, Chaudhari, Rong, Ma
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The heterogeneity of store-operated calcium entry in melanoma [PDF]
Science China Life Sciences, 2016 Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells.
Hooper, Robert +2 more
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TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
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Frontiers in Cell and Developmental Biology, 2021 Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. Here we have used the induced pluripotent stem cell technology to produce patient-specific terminally ...
Vladimir A. Vigont +17 more
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Frontiers in Cellular Neuroscience, 2021 It is well-established that astrocytes respond to norepinephrine with cytosolic calcium rises in various brain areas, such as hippocampus or neocortex. However, less is known about the effect of norepinephrine on olfactory bulb astrocytes. In the present
Timo Fischer +4 more
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