Results 51 to 60 of about 802,879 (181)

Modulation of Transient Receptor Potential C Channel Activity by Cholesterol

Frontiers in Pharmacology, 2019
Changes of cholesterol level in the plasma membrane of cells have been shown to modulate ion channel function. The proposed mechanisms underlying these modulations include association of cholesterol to a single binding site at a single channel ...
Rita Gutorov, Maximilian Peters, Ben Katz, Tal Brandwine, Nicolas A. Barbera, Irena Levitan, Baruch Minke   +6 more
doaj   +1 more source

CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity

Molecular Metabolism, 2022
Objective: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic ...
Jian Qiu, Martha A. Bosch, Todd L. Stincic, Avery C. Hunker, Larry S. Zweifel, Oline K. Rønnekleiv, Martin J. Kelly   +6 more
doaj   +1 more source

TRPC channels as STIM1-regulated SOCs [PDF]

Channels, 2009
Store-operated Ca(2+) channels (SOCs) are Ca(2+) influx channels at the plasma membrane whose opening is determined by the level of Ca(2+) stored in the endoplasmic reticulum lumen. SOCs are activated in response to receptor-mediated or passive depletion of ER Ca(2+) to regulate many Ca(2+)-dependent cellular functions.
Joseph P, Yuan, Min Seuk, Kim, Weizhong, Zeng, Dong Min, Shin, Guo, Huang, Paul F, Worley, Shmuel, Muallem   +6 more
openaire   +2 more sources

Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels

Cells, 2018
Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels.
Michael Mederos y Schnitzler, Thomas Gudermann, Ursula Storch   +2 more
doaj   +1 more source

TRPC channels in smooth muscle cells [PDF]

Frontiers in Bioscience, 2010
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the ...
Jose C, Gonzalez-Cobos, Mohamed, Trebak
openaire   +2 more sources

Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. [PDF]

PLoS ONE, 2007
The canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that are activated by increases in intracellular Ca(2+) and G(q)/phospholipase C-coupled receptors.
Melissa A Fowler, Kyriaki Sidiropoulou, Emin D Ozkan, Christopher W Phillips, Donald C Cooper   +4 more
doaj   +1 more source

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

Association of Immunophilins with Mammalian TRPC Channels [PDF]

Journal of Biological Chemistry, 2004
Drosophila photoreceptor channels TRP and TRPL are held in a large signalplex by the scaffolding protein, INAD. Immunophilin FKBP59, another member of the signalplex, binds to both INAD and TRPL. Mutation P702Q or P709Q in the highly conserved TRPL sequence (701)LPPPFNVLP(709), eliminates TRPL interaction with FKBP59.
William G, Sinkins, Monu, Goel, Mark, Estacion, William P, Schilling   +3 more
openaire   +2 more sources

TRPC expression in human periodontal ligament cells and the periodontal tissue of periodontitis mice: a preliminary study

Laboratory Animal Research, 2023
Background Transient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca2+ and Na+. Despite their importance, there are currently few studies on TRPC in the periodontal ligament (PDL) and bone cells in
Aeryun Kim, Ae Ri Kim, Yeong-Eui Jeon, Yun‑Jung Yoo, Yu-Mi Yang, Eun‑Jung Bak   +5 more
doaj   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source