Results 1 to 10 of about 5,964 (128)

TRPC6 mediates goblet cell differentiation in COPD [PDF]

Respiratory Research
Background Goblet cell metaplasia is a pathological feature of airway remodelling in chronic obstructive pulmonary disease (COPD). Basal cell clones with goblet cell metaplasia demonstrate high transient receptor potential cation channel subfamily C ...
Haiqing Li, Guoping Hu, Lizhi Huang, Erkang Yi, Nan Di, Jingwen Li, Chuang Hu, Li Che, Yuning Huang, Jiaqi Wang, Qianmei Wen, Xiaojing Yang, Yu Liu, Ge Bai, Xiaoyan Lu, Weitao Cao, Xinyue Mei, Xinyuan Liu, Peiyi Li, Fan Wu, Binwei Hao, Jinding Pu, Xinru Ran, Ruiting Sun, Wei Hong, Yang Peng, Yumin Zhou, Wenguang Yin, Pixin Ran   +28 more
doaj   +2 more sources

AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function

Frontiers in Cell and Developmental Biology, 2021
Transient Receptor Potential Canonical 6 (TRPC6) has been suggested to be involved in synapse function and contribute to hippocampal-dependent cognitive processes. Gene silencing of TRPC6 was performed by injecting adeno-associated virus (AAV) expressing
Xiaotang Fan, Rui Xiao, Keyi Lv
exaly   +3 more sources

TRPC6-Mediated Ca²⁺ Influx Activates MAPK and NFκB Signaling and Elicits Pro-Inflammatory and Catabolic Responses in Human Intervertebral Disc Cells [PDF]

Cells
Intervertebral disc degeneration is characterized by inflammation, extracellular matrix breakdown, and neurovascular ingrowth, processes that contribute to discogenic, chronic back pain.
Janitri Venkatachala Babu, Varun Puvanesarajah, Addisu Mesfin, Jonathan P. Japa, Kevin Yoon, Mark Ehioghae, Michael G. Schrlau, Laura S. Stone, Wolfgang Hitzl, Karin Wuertz-Kozak   +9 more
doaj   +2 more sources

TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis [PDF]

Molecular Metabolism
Brown adipose tissue (BAT) thermogenesis combats obesity, but mechanisms linking calcium dynamics to thermogenic programming remain incompletely defined.
Danyingzhu Xie, Ying Peng, Susu Zhang, Xudong Mai, Weiheng Wen, Ming Wang, Qiao-Ping Wang, Jia Sun   +7 more
doaj   +2 more sources

TRPC6 Attenuates Cortical Astrocytic Apoptosis and Inflammation in Cerebral Ischemic/Reperfusion Injury

Frontiers in Cell and Developmental Biology, 2021
Transient receptor potential canonical 6 (TRPC6) channel is an important non-selective cation channel with a variety of physiological roles in the central nervous system.
Xiaoxing Xiong, Shengmei Zhu, Lu Liu
exaly   +3 more sources

Inhibition of TRPC6 channel suppresses bladder cancer proliferation by disrupting store-operated calcium entry [PDF]

Scientific Reports
Despite its prevalence, bladder cancer (BC) remains an unsolved pathogenesis. It is believed that TRPC6 channels have unique electrophysiological properties that contribute to intracellular Ca2+  signalling and tumorigenesis in cells.
Jinhui Zha, Xiaotong Guo, Wentao Liao, Peitao Wu, Yuhong Wu, Yingyue Guo, Weifeng Yang, Li Gao   +7 more
doaj   +2 more sources

Photopharmacology reveals high-specificity linkage of Ca2+ entry at TRPC6 nanodomains to NFAT activation in mast cells [PDF]

Frontiers in Immunology
IntroductionPhotopharmacology has recently emerged as a strategy for high-precision modulation of immune functions. Here we explored efficiency and specificity of interventions based on light-induced TRPC6 activation in the RBL-2H3 mast cell model ...
Denis Krivić, Olga Panasiuk, Johannes Pilic, Roland Malli, Roland Malli, Bernadett Bacsa, Bernadett Bacsa, Sanja Ćurčić, Sanja Ćurčić, Klaus Groschner, Klaus Groschner   +10 more
doaj   +2 more sources

Potential Drug Candidates to Treat TRPC6 Channel Deficiencies in the Pathophysiology of Alzheimer’s Disease and Brain Ischemia

Cells, 2020
Alzheimer’s disease and cerebral ischemia are among the many causative neurodegenerative diseases that lead to disabilities in the middle-aged and elderly population. There are no effective disease-preventing therapies for these pathologies.
Daria Chernyuk, Veronika A Prikhodko, Elena Popugaeva   +2 more
exaly   +3 more sources

TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy [PDF]

Journal of Nanobiotechnology
Background Glucocorticoid (GC) intolerance and systemic toxicity pose significant challenges in the treatment of primary nephrotic syndrome (PNS), underscoring the urgent need for targeted therapies that maximize efficacy while minimizing adverse effects.
Lin Wu, Yang Liu, Ziqi Fu, Honglei Guo, Kang Liu, Jiafa Ren, Zhimin Huang, Fang Yang, Huijuan Mao   +8 more
doaj   +2 more sources

TRPC6 effects on albumin permeation, nephrin shedding, and apoptosis in podocytes: Role of calcineurin and metalloproteases [PDF]

Physiological Reports
The effects of TRPC6 activation for various periods of time on three classes of functional outputs were examined in cultured podocytes: albumin permeation across a confluent layer; changes in nephrin dynamics; and cell death.
Eun Young Kim, Stuart E. Dryer
doaj   +2 more sources