Results 1 to 10 of about 7,679 (208)

Genetic ablation of TRPC6 facilitated age-dependent atherosclerosis progression in an ApoE-/- mouse model [PDF]

Frontiers in Physiology
BackgroundTRPC6 channels are expressed in endothelial cells, smooth muscle cells, and macrophages within the atherosclerotic segments of conduit blood vessels.
Isaac S. Demaree, Sreepadaarchana Munjuluri, Saketh Boyapalli, Regan E. Beaty, Dru A. Wilkerson, Sruthilatha Sakthi Velavan, Fletcher A. White, Alexander G. Obukhov   +7 more
doaj   +2 more sources

Urotensin II Receptor Deletion Mitigates Kidney Injury and Renal Lipid Remodeling in Mice Fed a Long-Term High-Fat Diet. [PDF]

FASEB Bioadv
Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Kanthakumar P, Adebiyi A.
europepmc   +2 more sources

TRPC6 mediates goblet cell differentiation in COPD [PDF]

Respiratory Research
Background Goblet cell metaplasia is a pathological feature of airway remodelling in chronic obstructive pulmonary disease (COPD). Basal cell clones with goblet cell metaplasia demonstrate high transient receptor potential cation channel subfamily C ...
Haiqing Li, Guoping Hu, Lizhi Huang, Erkang Yi, Nan Di, Jingwen Li, Chuang Hu, Li Che, Yuning Huang, Jiaqi Wang, Qianmei Wen, Xiaojing Yang, Yu Liu, Ge Bai, Xiaoyan Lu, Weitao Cao, Xinyue Mei, Xinyuan Liu, Peiyi Li, Fan Wu, Binwei Hao, Jinding Pu, Xinru Ran, Ruiting Sun, Wei Hong, Yang Peng, Yumin Zhou, Wenguang Yin, Pixin Ran   +28 more
doaj   +2 more sources

TRPC6-Mediated Ca²⁺ Influx Activates MAPK and NFκB Signaling and Elicits Pro-Inflammatory and Catabolic Responses in Human Intervertebral Disc Cells [PDF]

Cells
Intervertebral disc degeneration is characterized by inflammation, extracellular matrix breakdown, and neurovascular ingrowth, processes that contribute to discogenic, chronic back pain.
Janitri Venkatachala Babu, Varun Puvanesarajah, Addisu Mesfin, Jonathan P. Japa, Kevin Yoon, Mark Ehioghae, Michael G. Schrlau, Laura S. Stone, Wolfgang Hitzl, Karin Wuertz-Kozak   +9 more
doaj   +2 more sources

Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats

Cells, 2021
Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) in patients and animal models, as well as in renal fibrosis following ureteral obstruction in ...
Eun Young Kim, Stuart E. Dryer
exaly   +3 more sources

TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis [PDF]

Molecular Metabolism
Brown adipose tissue (BAT) thermogenesis combats obesity, but mechanisms linking calcium dynamics to thermogenic programming remain incompletely defined.
Danyingzhu Xie, Ying Peng, Susu Zhang, Xudong Mai, Weiheng Wen, Ming Wang, Qiao-Ping Wang, Jia Sun   +7 more
doaj   +2 more sources

TRPC6 loss triggers mitochondrial dysfunction that drives white adipose tissue vulnerability to obesity and insulin resistance [PDF]

Experimental and Molecular Medicine
Calcium signaling is essential for adipocyte function; however, the upstream Ca2+ channels coordinating adipose metabolism remain poorly defined. Here, we identify TRPC6 as a Ca2+ channel enriched in early adipocyte progenitors that orchestrate white ...
Phan Anh Nguyen, Kyu-Hee Hwang, Duyen Thi Thuy Tran, Tae Sic Lee, Kyu-Sang Park, Seung-Kuy Cha   +5 more
doaj   +2 more sources

Inhibition of TRPC6 channel suppresses bladder cancer proliferation by disrupting store-operated calcium entry [PDF]

Scientific Reports
Despite its prevalence, bladder cancer (BC) remains an unsolved pathogenesis. It is believed that TRPC6 channels have unique electrophysiological properties that contribute to intracellular Ca2+  signalling and tumorigenesis in cells.
Jinhui Zha, Xiaotong Guo, Wentao Liao, Peitao Wu, Yuhong Wu, Yingyue Guo, Weifeng Yang, Li Gao   +7 more
doaj   +2 more sources

TRPC6 effects on albumin permeation, nephrin shedding, and apoptosis in podocytes: Role of calcineurin and metalloproteases [PDF]

Physiological Reports
The effects of TRPC6 activation for various periods of time on three classes of functional outputs were examined in cultured podocytes: albumin permeation across a confluent layer; changes in nephrin dynamics; and cell death.
Eun Young Kim, Stuart E. Dryer
doaj   +2 more sources

Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models.

PLoS ONE, 2022
Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6.
Brittney J Brown, Kimber L Boekell, Brian R Stotter, Brianna E Talbot, Johannes S Schlondorff   +4 more
doaj   +2 more sources