Results 11 to 20 of about 7,679 (208)

A novel TRPC6 mutation that causes childhood FSGS.

PLoS ONE, 2009
BackgroundTRPC6, encoding a member of the transient receptor potential (TRP) superfamily of ion channels, is a calcium-permeable cation channel, which mediates capacitive calcium entry into the cell.
Saskia F Heeringa, Clemens C Möller, Jianyang Du, Lixia Yue, Bernward Hinkes, Gil Chernin, Christopher N Vlangos, Peter F Hoyer, Jochen Reiser, Friedhelm Hildebrandt   +9 more
doaj   +4 more sources

Revisiting TRPC1 and TRPC6 mechanosensitivity [PDF]

Pflügers Archiv - European Journal of Physiology, 2007
This article addresses whether TRPC1 or TRPC6 is an essential component of a mammalian stretch-activated mechano-sensitive Ca(2+) permeable cation channel (MscCa). We have transiently expressed TRPC1 and TRPC6 in African green monkey kidney (COS) or Chinese hamster ovary (CHO) cells and monitored the activity of the stretch-activated channels using a ...
Gottlieb, P., Folgering, J., Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Bowman, C., Bichet, D., Patel, A., Sachs, F., Martinac, B., Hamill, O. P., Honore, E.   +12 more
openaire   +6 more sources

TRPC6 Enhances Angiotensin II-induced Albuminuria [PDF]

Journal of the American Society of Nephrology, 2011
Mutations in the canonical transient receptor potential cation channel 6 (TRPC6) are responsible for familial forms of adult onset focal segmental glomerulosclerosis (FSGS). The mechanisms by which TRPC6 mutations cause kidney disease are not well understood. We used TRPC6-deficient mice to examine the function of TRPC6 in the kidney.
Eckel, Jason, Lavin, Peter J, Finch, Elizabeth A, Mukerji, Nirvan, Burch, Jarrett, Gbadegesin, Rasheed, Wu, Guanghong, Bowling, Brandy, Byrd, Alison, Hall, Gentzon, Sparks, Matthew, Zhang, Zhu Shan, Homstad, Alison, Barisoni, Laura, Birbaumer, Lutz, Rosenberg, Paul, Winn, Michelle P   +16 more
openaire   +4 more sources

TRPC6 and FSGS: The latest TRP channelopathy [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
Focal and segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome in children and adults throughout the world. In the past 50 years, significant advances have been made in the identification and characterization of familial forms of nephrotic syndrome and FSGS.
Mukerji, Nirvan, Damodaran, Tirupapuliyur V., Winn, Michelle P.   +2 more
openaire   +3 more sources

VEGF regulates TRPC6 channels in podocytes

Nephrology Dialysis Transplantation, 2011
Both, increased plasma concentrations of vascular endothelial growth factor (VEGF) and increased expression of transient receptor potential canonical type 6 (TRPC6) channels in podocytes have been associated with proteinuric kidney diseases. Now, we investigated the hypothesis that VEGF regulates TRPC6 in podocytes.TRPC6 messenger RNA (mRNA) and TRPC6 ...
Thilo, Florian, Liu, Ying, Loddenkemper, Christoph, Schuelein, Ralf, Schmidt, Antje, Yan, Zengcheng, Zhu, Zhiming, Zakrzewicz, Andreas, Gollasch, Maik, Tepel, Martin; id_orcid 0000-0002-0086-0997   +9 more
openaire   +3 more sources

TRPC6 Is Found in Distinct Compartments of the Human Kidney [PDF]

International Journal of Translational Medicine, 2022
In the context of renal proteinuric diseases, TRPC6 has been shown to play an important role in ultrafiltration associated with the slit diaphragm through the control of the intracellular Ca2+ concentration in the podocytes of glomeruli. However, to date,
Colya N. Englisch, Daniel Röhricht, Mariesa Walz, Kerstin Junker, Anja Beckmann, Carola Meier, Friedrich Paulsen, Martin Jung, Thomas Tschernig   +8 more
doaj   +2 more sources

Activation of Human TRPC6 Channels by Receptor Stimulation [PDF]

Journal of Biological Chemistry, 2004
The human TRPC6 channel was expressed in human embryonic kidney (HEK) cells, and activity was monitored using the giga-seal technique. Whole cell membrane currents with distinctive inward and outward rectification were activated by carbachol (CCh) in TRPC6-expressing cells, but not in lacZ-transfected controls.
Mark, Estacion, Su, Li, William G, Sinkins, Martin, Gosling, Parmjit, Bahra, Chris, Poll, John, Westwick, William P, Schilling   +7 more
openaire   +3 more sources

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols [PDF]

, 2023
The selective modulation of TRPC6 ion channels has emerged as a promising therapeutic approach for treating neuro-degenerative diseases and depression. Here, we present a significant advancement in this field by demonstrating the se-lective activation of
Philipp, Peslalz, Bernd, Plietker, Andreas , Kany, Yamina, El Hamdaoui, Kristina, Friedland, Anton, Bleisch, Frank, Kraus, Anna, Hirsch, Flavia, Izzo, Ina, Schulz   +9 more
core   +1 more source

AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function

Frontiers in Cell and Developmental Biology, 2021
Transient Receptor Potential Canonical 6 (TRPC6) has been suggested to be involved in synapse function and contribute to hippocampal-dependent cognitive processes. Gene silencing of TRPC6 was performed by injecting adeno-associated virus (AAV) expressing
Ruxin Xie, Zhongke Wang, Tianyao Liu, Rui Xiao, Keyi Lv, Chuan Wu, Yi Luo, Yun Cai, Xiaotang Fan   +8 more
doaj   +1 more source

Mammalian target of rapamycin complex 2 signaling pathway regulates transient receptor potential cation channel 6 in podocytes. [PDF]

PLoS ONE, 2014
Transient receptor potential cation channel 6 (TRPC6) is a nonselective cation channel, and abnormal expression and gain of function of TRPC6 are involved in the pathogenesis of hereditary and nonhereditary forms of renal disease.
Fangrui Ding, Xiaoyan Zhang, Xuejuan Li, Yanqin Zhang, Baihong Li, Jie Ding   +5 more
doaj   +1 more source