Results 11 to 20 of about 6,014 (173)

A novel TRPC6 mutation that causes childhood FSGS.

PLoS ONE, 2009
BackgroundTRPC6, encoding a member of the transient receptor potential (TRP) superfamily of ion channels, is a calcium-permeable cation channel, which mediates capacitive calcium entry into the cell.
Saskia F Heeringa, Clemens C Möller, Jianyang Du, Lixia Yue, Bernward Hinkes, Gil Chernin, Christopher N Vlangos, Peter F Hoyer, Jochen Reiser, Friedhelm Hildebrandt   +9 more
doaj   +3 more sources

Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models.

PLoS ONE, 2022
Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6.
Brittney J Brown, Kimber L Boekell, Brian R Stotter, Brianna E Talbot, Johannes S Schlondorff   +4 more
doaj   +2 more sources

Mammalian target of rapamycin complex 2 signaling pathway regulates transient receptor potential cation channel 6 in podocytes. [PDF]

PLoS ONE, 2014
Transient receptor potential cation channel 6 (TRPC6) is a nonselective cation channel, and abnormal expression and gain of function of TRPC6 are involved in the pathogenesis of hereditary and nonhereditary forms of renal disease.
Fangrui Ding, Xiaoyan Zhang, Xuejuan Li, Yanqin Zhang, Baihong Li, Jie Ding   +5 more
doaj   +1 more source

TRPC6 Inactivation Reduces Albuminuria Induced by Protein Overload in Sprague Dawley Rats

Cells, 2022
Canonical transient receptor potential-6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS), and in renal fibrosis following ureteral obstruction in mice.
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source

Role of TRPC6 in kidney damage after acute ischemic kidney injury

Scientific Reports, 2022
Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca2+ and other monovalent cations into cells, is widely expressed in the kidney.
Zhihuang Zheng, Dmitry Tsvetkov, Theda Ulrike Patricia Bartolomaeus, Cem Erdogan, Ute Krügel, Johanna Schleifenbaum, Michael Schaefer, Bernd Nürnberg, Xiaoning Chai, Friedrich-Alexander Ludwig, Gabriele N’diaye, May-Britt Köhler, Kaiyin Wu, Maik Gollasch, Lajos Markó   +14 more
doaj   +1 more source

Elderly with Varying Extents of Cardiac Disease Show Interindividual Fluctuating Myocardial TRPC6-Immunoreactivity

Journal of Cardiovascular Development and Disease, 2023
Both particular myocardial locations in the human heart and the canonical transient receptor potential 6 (TRPC6) cation channel have been linked with cardiac pathophysiologies.
Jan Michael Federspiel, Jil Gartner, Peter Lipp, Peter Schmidt, Thomas Tschernig   +4 more
doaj   +1 more source

Revisiting TRPC1 and TRPC6 mechanosensitivity [PDF]

Pflügers Archiv - European Journal of Physiology, 2007
This article addresses whether TRPC1 or TRPC6 is an essential component of a mammalian stretch-activated mechano-sensitive Ca(2+) permeable cation channel (MscCa). We have transiently expressed TRPC1 and TRPC6 in African green monkey kidney (COS) or Chinese hamster ovary (CHO) cells and monitored the activity of the stretch-activated channels using a ...
Gottlieb, P., Folgering, J., Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Bowman, C., Bichet, D., Patel, A., Sachs, F., Martinac, B., Hamill, O. P., Honore, E.   +12 more
openaire   +5 more sources

TRPC6 is altered in COVID-19 pneumonia

Chemico-Biological Interactions, 2022
In this Letter to the Editor supportive data were presented to a recent paper published in this journal reporting the involvement of TRP channels in COVID-19 pneumonia and its role for new therapies. Since gene expression of TRP channels was found in human lung tissues the protein was not being reported so far.
Gina Leidinger, Fidelis Flockerzi, Johannes Hohneck, Rainer M. Bohle, Armin Fieguth, Thomas Tschernig   +5 more
openaire   +2 more sources

Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells

Renal Failure, 2022
Purpose Glomerular mesangial cell (GMC) dysfunction plays a vital role in the pathogenesis of diabetic kidney disease (DKD). Transient receptor potential canonical 6 (TRPC6) has been demonstrated to be involved in the development of DKD.
Jian Yu, Chunchun Li, Lisha Ma, Bin Zhai, Aiping Xu, Decui Shao   +5 more
doaj   +1 more source

Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats

Cells, 2021
Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) in patients and animal models, as well as in renal fibrosis following ureteral obstruction in ...
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source