Results 41 to 50 of about 7,679 (208)

Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury

JVS - Vascular Science, 2020
Objective: Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies utilizing a carotid wire-injury
Andrew H. Smith, MD, Priya Putta, PhD, Erin C. Driscoll, BS, Pinaki Chaudhuri, PhD, Lutz Birnbaumer, PhD, Michael A. Rosenbaum, MD, Linda M. Graham, MD   +6 more
doaj   +1 more source

Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress

Stem Cell Research & Therapy, 2022
Introduction The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention.
Li Wang, Hong Liang, Bingjing Sun, Jing Mi, Xianqin Tong, Yuhui Wang, Meihua Chen, Liming Yu, Jie Pan, Shangfeng Liu, Yan-Jun Liu, Yuehua Liu   +11 more
doaj   +1 more source

Regulation of TRPC6 Channel Activity by Tyrosine Phosphorylation [PDF]

Journal of Biological Chemistry, 2004
Various hormonal stimuli and growth factors activate the mammalian canonical transient receptor potential (TRPC) channel through phospholipase C (PLC) activation. However, the precise mechanism of the regulation of TRPC channel activity remains unknown.
Chihiro, Hisatsune, Yukiko, Kuroda, Kyoko, Nakamura, Takafumi, Inoue, Takeshi, Nakamura, Takayuki, Michikawa, Akihiro, Mizutani, Katsuhiko, Mikoshiba   +7 more
openaire   +2 more sources

Pharmakologische und genetische Hemmung der TRPC6-induzierten Gentranskription [PDF]

, 2022
Der „transient receptor potential canonical“-6-Kanal (TRPC6) ist ein nichtselektiver Kalzium-Ionen Kanal, der in menschlichen Zellen zu finden ist. Wird der Kanal aktiviert, induziert er eine Signalkaskade, die über die„mitogen-activated-protein“-Kinase-
Scheuble, Julia
core   +1 more source

Integration of Phosphoinositide- and Calmodulin-Mediated Regulation of TRPC6 [PDF]

Molecular Cell, 2007
Multiple TRP channels are regulated by phosphoinositides (PIs). However, it is not known whether PIs bind directly to TRP channels. Furthermore, the mechanisms through which PIs regulate TRP channels are obscure. To analyze the role of PI/TRP interactions, we used a biochemical approach, focusing on TRPC6.
Kwon, Young, Hofmann, Thomas, Montell, Craig   +2 more
openaire   +2 more sources

Structural basis for pharmacological modulation of the TRPC6 channel

eLife, 2020
Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathological cardiac and renal conditions, mechanistic understanding of TRPC6 function and modulation remains ...
Yonghong Bai, Xinchao Yu, Hao Chen, Daniel Horne, Ryan White, Xiaosu Wu, Paul Lee, Yan Gu, Sudipa Ghimire-Rijal, Daniel C-H Lin, Xin Huang   +10 more
openaire   +3 more sources

Der nicht-selektive Kationenkanal TRPC6 in menschlichen Gefäßen [PDF]

, 2022
Zusammenfassung 1.1 Zusammenfassung (english version below) 1.1.1 Einleitung und klinische Relevanz Kardiovaskuläre Erkrankungen sind eine der häufigsten Todesursachen weltweit.
Abdinghoff, Jan, Abdinghoff, Jan Josef Joachim   +1 more
core   +1 more source

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells.

, 2005
NIH: HL55426 y AI058173 Interdisciplinary Training Program in Muscle Biology, University of Maryland School of MedicineThe ubiquitously expressed canonical transient receptor potential (TRPC) ion channels are considered important in Ca2+ signal ...
Spassova, Maria, Soboloff, Jonathan, Wen, Xu, Cuesta Rubio, Natalia, Gill, Donald, Li-Ping, He   +5 more
core   +1 more source

TRPC6 mediates high glucose-induced mitochondrial fission through activation of CDK5 in cultured human podocytes

Frontiers in Physiology, 2022
Mitochondrial abnormalities contribute to the development of diabetic nephropathy (DN). However, the precise mechanisms of mitochondrial dysfunction in DN remain unclear.
Haomiao Yu, Yili Chen, Huimin Ma, Zihan Wang, Rui Zhang, Jundong Jiao, Jundong Jiao   +6 more
doaj   +1 more source