Results 61 to 70 of about 6,014 (173)
High Glucose-Induced TRPC6 Channel Activation Decreases Glutamate Uptake in Rat Retinal Müller Cells
Frontiers in Pharmacology, 2020 High glucose (HG) increases the production of reactive oxygen species (ROS), leading to decreased glutamate uptake in Müller cells. The transient receptor potential cation channel 6 (TRPC6) channel, an oxidative stress-sensitive Ca2+-permeable cationic ...
Mingming Ma +29 more
doaj +1 more source
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, Volume 13, Issue 33, 15 June 2026.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
Journal of Chemometrics, Volume 40, Issue 6, June 2026.ABSTRACT This study investigates the performance of near‐infrared (NIR)‐based partial least squares (PLS) regression models for quantifying hyperforin in Hypericum perforatum L., with particular emphasis on temporal validation and robustness analysis. Dried and ground Hypericum samples were analyzed using three different NIR spectrometers: one benchtop
Nele‐Elin Schröter, Knut Baumann
wiley +1 more source
Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes
Clinical and Translational Medicine, 2020 Background Recurrent moderate hypoglycemia (RH), a major adverse effect of hypoglycemic therapy in diabetic patients, is one of the main risk factors for cognitive impairment and dementia.
Chengkang He +15 more
doaj +1 more source
A critical role for the transient receptor potential channel type 6 in human platelet activation. [PDF]
PLoS ONE, 2015 While calcium signaling is known to play vital roles in platelet function, the mechanisms underlying its receptor-operated calcium entry component (ROCE) remain poorly understood.
Hari Priya Vemana +3 more
doaj +1 more source
Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound
Advanced Science, Volume 13, Issue 26, 8 May 2026.In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He +8 more
wiley +1 more source
Mechanobiology in Stem Cell‐Based Bioprinting
Cell Proliferation, Volume 59, Issue 5, May 2026.Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley +1 more source
Journal of Pain Research, 2022 Songchao Xu,1 Yusheng Yi,2 Yanting Wang,1 Pei Wang,1 Yang Zhao,1 Wei Feng1 1Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People’s Republic of China; 2Department of Algology, Affiliated Hospital of ...
Xu S +5 more
doaj
Journal of Diabetes Investigation, Volume 17, Issue 5, Page 766-780, May 2026.This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu +4 more
wiley +1 more source
Cells, 2019 Transient receptor potential canonical channel-6 (TRPC6) is one of the Ca2+-permeable non-selective cation channels. TRPC6 is mainly expressed in dentate granule cell (DGC), which is one of the most resistant neuronal populations to various harmful ...
Ji-Eun Kim +4 more
doaj +1 more source