Results 61 to 70 of about 7,679 (208)

p53 transcriptionally regulates TRPC6 promoter.

, 2013
A) A putative p53 binding site is observed in the TRPC6 promoter using Genomatix, Matinspector module. TRPC6-p53RE lies between −422 to −400 bp on the 0.6 kb TRPC6 promoter.
Uttam Pati (258033), Rajan Gogna (258030), Esha Madan (446812), Bernhard Keppler (446813)   +3 more
core   +1 more source

The roles of TRPC6 in renal tubular disorders: a narrative review

Renal Failure
The transient receptor potential canonical 6 (TRPC6) channel, a nonselective cation channel that allows the passage of Ca2+, plays an important role in renal diseases. TRPC6 is activated by Ca2+ influx, oxidative stress, and mechanical stress.
Aiqin Sheng, Fei Liu, Qianhui Wang, Haidong Fu, Jianhua Mao   +4 more
doaj   +1 more source

Sildenafil Prevents Podocyte Injury via PPAR-γ-Mediated TRPC6 Inhibition [PDF]

, 2016
Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria.
van der Vlag, Johan, Dijkman, Henry B, Andrea M. Isidori, Berden, Jo H, Nijenhuis, Tom, Berden, J.H., ISIDORI, Andrea, Carole Henique, Henique, C., Johan van der Vlag, Joost G. Hoenderop, Tom Nijenhuis, Dijkman, H.B.P.M., Tharaux, P.L., Hoenderop, J.G.J., Isidori, A.M., Ramon Sonneveld, Vlag, J. van der, Pierre-Louis Tharaux, Sonneveld, Ramon, Henique, Carole, Henry B. Dijkman, Jo H. Berden, Hoenderop, Joost G, Sonneveld, R., Nijenhuis, T., Tharaux, Pierre Louis   +26 more
core   +2 more sources

Potential Drug Candidates to Treat TRPC6 Channel Deficiencies in the Pathophysiology of Alzheimer’s Disease and Brain Ischemia

Cells, 2020
Alzheimer’s disease and cerebral ischemia are among the many causative neurodegenerative diseases that lead to disabilities in the middle-aged and elderly population. There are no effective disease-preventing therapies for these pathologies.
Veronika Prikhodko, Daria Chernyuk, Yurii Sysoev, Nikita Zernov, Sergey Okovityi, Elena Popugaeva   +5 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Characterization of TRPC6 expression and GSK1702934A response in Trpc6 mutant platelets.

, 2022
A, platelet lysates from wild-type (WT) and Trpc6-/- (KO) littermate mice were analyzed by SDS-PAGE and western blot. Anti-TRPC6 antibodies (top) detected a major band around 105 kD in WT but not KO mice.
Brianna E. Talbot (12936660), Kimber L. Boekell (12936654), Johannes S. Schlondorff (12936663), Brittney J. Brown (12936657)   +3 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Generation and analysis of modified Trpc6 cDNA's.

, 2013
(A) Schematic representation of the Trpc6 constructs utilized for the in vitro studies. Chromatograms of mutations C332A and G2683A that generate aminoacid substitutions P111Q and E896K are shown.
Cesar P. Canales (134406), Jing Li (10611), J. Daniel Carpio (361627), Phillip Ruiz (106963), Juan I. Young (134419), Paola Krall (361623), Paulina Carmona-Mora (134403), Jessica Molina (236817), Pamela Kairath (361624), Katherina Walz (134422), Jochen Reiser (252451), Changli Wei (361630), Sergio A. Mezzano (361629)   +12 more
core   +1 more source

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Scientific Reports, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Sayaka Oda, Takuro Numaga-Tomita, Naoyuki Kitajima, Takashi Toyama, Eri Harada, Tsukasa Shimauchi, Akiyuki Nishimura, Tatsuya Ishikawa, Yoshito Kumagai, Lutz Birnbaumer, Motohiro Nishida   +10 more
doaj   +1 more source

TRPC6-mediated ERK1/2 Activation Regulates Neuronal Excitability via Subcellular Kv4.3 Localization in the Rat Hippocampus

Frontiers in Cellular Neuroscience, 2017
Recently, we have reported that transient receptor potential channel-6 (TRPC6) plays an important role in the regulation of neuronal excitability and synchronization of spiking activity in the dentate granule cells (DGC).
Ji-Eun Kim, Jin-Young Park, Tae-Cheon Kang   +2 more
doaj   +1 more source