Results 81 to 90 of about 7,679 (208)

High Glucose-Induced TRPC6 Channel Activation Decreases Glutamate Uptake in Rat Retinal Müller Cells

Frontiers in Pharmacology, 2020
High glucose (HG) increases the production of reactive oxygen species (ROS), leading to decreased glutamate uptake in Müller cells. The transient receptor potential cation channel 6 (TRPC6) channel, an oxidative stress-sensitive Ca2+-permeable cationic ...
Mingming Ma, Mingming Ma, Mingming Ma, Mingming Ma, Mingming Ma, Shuzhi Zhao, Shuzhi Zhao, Shuzhi Zhao, Shuzhi Zhao, Shuzhi Zhao, Jian Zhang, Jian Zhang, Jian Zhang, Jian Zhang, Jian Zhang, Tao Sun, Tao Sun, Tao Sun, Tao Sun, Tao Sun, Ying Fan, Ying Fan, Ying Fan, Ying Fan, Ying Fan, Zhi Zheng, Zhi Zheng, Zhi Zheng, Zhi Zheng, Zhi Zheng   +29 more
doaj   +1 more source

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, Volume 40, Issue 15, August 2026.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source

Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes

Clinical and Translational Medicine, 2020
Background Recurrent moderate hypoglycemia (RH), a major adverse effect of hypoglycemic therapy in diabetic patients, is one of the main risk factors for cognitive impairment and dementia.
Chengkang He, Peng Gao, Yuanting Cui, Qiang Li, Yingsha Li, Zongshi Lu, Huan Ma, Yu Zhao, Li Li, Fang Sun, Xiaowei Chen, Hongbo Jia, Daoyan Liu, Gangyi Yang, Hongting Zheng, Zhiming Zhu   +15 more
doaj   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, Volume 81, Issue 8, Page 2675-2712, August 2026.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Smooth muscle cell polycystin 1 (PKD1) is dispensable for physiological regulation of arterial contractility

The Journal of Physiology, Volume 604, Issue 15, Page 6348-6368, 1 August 2026.
Abstract figure legend Physiological functions of PKD1, a large transmembrane polycystin protein, are unclear. Previous results obtained using germline non‐specific knockout mice suggested that PKD1 regulates arterial smooth muscle cell contractility.
Angélica K. Bernardelli, Roberto B. Pontes, Alejandro Mata‐Daboin, Tessa A. C. Garrud, Ulrich C. Mbiakop, Marcos A. S. Leal, Dieniffer Peixoto‐Neves, Jonathan H. Jaggar   +7 more
wiley   +1 more source

Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Mechanosensitive cation channels expressed in pulmonary arterial smooth muscle (SMC) and endothelial (EC) cells contribute to the regulation of vasoconstriction and vasodilation of the pulmonary vasculature. Here, we report that activating Piezo1, a mechanosensitive cation channel, with Yoda1 induced a mild increase in pulmonary arterial ...
Sophia Parmisano, Jiyuan Chen, Yuqin Chen, Pritesh P. Jain, Lauren Yung, Wei‐Ting Wang, Ting Wang, Xiang Li, Angela Balistrieri, Sophia A. Ferrizzi, Cassia Pedron, Owen Brooks, Mona Alotaibi, Jian Wang, Joe G.N. Garcia, Patricia A. Thistlethwaite, Ayako Makino, Jason X.‐J. Yuan   +17 more
wiley   +1 more source

TRPC6 G757D Loss-of-Function Mutation Associates with FSGS

, 2016
FSGS is a CKD with heavy proteinuria that eventually progresses to ESRD. Hereditary forms of FSGS have been linked to mutations in the transient receptor potential cation channel, subfamily C, member 6 (TRPC6) gene encoding a nonselective cation channel.
Winyard, P., Kolatsi-Joannou, M., Hoyer, P.F., Anja K. Büscher, Gohlke, B.O., Paul Winyard, Riehle, M., Harteneck, C., Maik Gollasch, Stefanie Weber, Gollasch, M., Becker, J.U., Jan H. Bräsen, Kaßmann, M., Marc Riehle, Björn-Oliver Gohlke, Mato Nagel, Jan U. Becker, Robert Preissner, Büscher, A.K., Peter F. Hoyer, Preissner, R., Maria Kolatsi-Joannou, Bräsen, J.H., Christian Harteneck, Mario Kaßmann, Krautwurst, D., Dietmar Krautwurst, Nagel, M., Weber, S.   +29 more
core   +1 more source

Dexmedetomidine Alleviates Neuropathic Pain via the TRPC6-p38 MAPK Pathway in the Dorsal Root Ganglia of Rats

Journal of Pain Research, 2022
Songchao Xu,1 Yusheng Yi,2 Yanting Wang,1 Pei Wang,1 Yang Zhao,1 Wei Feng1 1Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People’s Republic of China; 2Department of Algology, Affiliated Hospital of ...
Xu S, Yi Y, Wang Y, Wang P, Zhao Y, Feng W   +5 more
doaj  

Pulmonary Hypertension Molecular Switch: HIF Signaling Pathway

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary hypertension (PH) is a multifaceted disorder characterized by the crucial involvement of activated hypoxia‐inducible factors (HIFs). Recent investigations have unveiled HIFs' ability to orchestrate a wide array of signaling cascades, encompassing voltage‐gated potassium channels, non‐selective cation channels (NSCCs), Ca2+/PKC/MAPKs,
Yinhui Sun, Rongzhen Ding, Xianli Su, Li Qin, Lihuai Wang, Jian Yi, Ruicheng Hu, Shuying You, Zhenfei Tan, Aiguo Dai   +9 more
wiley   +1 more source

Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
TRPC proteins become involved in Ca2+ entry following the activation of Gq-protein coupled receptors. TRPC6 is inserted into the plasma membrane upon stimulation and remains in the plasma membrane as long as the stimulus is present. However, the mechanism that regulates the trafficking of TRPC6 is unclear.
Cayouette, Sylvie, Bousquet, Simon M., Francoeur, Nancy, Dupré, Émilie, Monet, Michaël, Gagnon, Hugo, Guedri, Youssef B., Lavoie, Christine, Boulay, Guylain   +8 more
openaire   +2 more sources