Results 71 to 80 of about 6,014 (173)
Physiological Reports, Volume 14, Issue 9, May 2026.Abstract Glomerular podocytes play a key role in the pathogenesis of diabetic kidney disease (DKD). Recent studies suggest that natriuretic peptides (NPs) are podocyte protective. The beneficial effects of NPs are inhibited by the removal of NPs from the circulation by the NP clearance receptor (NPRC).
Liming Wang +4 more
wiley +1 more source
Exploration, Volume 6, Issue 2, April 2026.Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9‐mediated RBFOX1 loss in APOE4 human cerebral organoids induces autonomous microglial genesis and accelerates AD pathology, revealing a protective role of RBFOX1 and establishing a model ...
Bowen Zhang +13 more
wiley +1 more source
Renal Failure, 2019 Objective: To investigate effects of combination use of leflunomide and benazepril on diabetic nephropathy (DN) both in vivo and in vitro. Methods: The streptozotocin (STZ) induced Sprague-Dawley rats were treated with leflunomide (15 mg/kg/d ...
Huili Li +5 more
doaj +1 more source
Inhibition of TRPC6 Signal Pathway Alleviates Podocyte Injury Induced by TGF-β1
Cellular Physiology and Biochemistry, 2017 Background/Aims: Transforming growth factor beta 1 (TGF-β1) plays a critical role in the pathogenesis of glomerulosclerosis. The purpose of this study was to examine the effects of inhibition of transient receptor potential cation channel C6 (TRPC6) on ...
Haiting Huang +8 more
doaj +1 more source
pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma
Acta Physiologica, Volume 242, Issue 4, April 2026.ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab +37 more
wiley +1 more source
PLoS ONE, 2020 α-Klotho is a type 1 transmembrane protein that exhibits aging suppression function. The large amino-terminal extracellular domain of α-klotho is shed as soluble klotho (sKlotho) and functions as a circulating cardioprotective hormone.
Jian Xie +4 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: Although increased expression and gain function of transient receptor potential cation channel 6 (TRPC6) has been associated with the pathogenesis of some proteinuric glomerular diseases, it remains elusive how TRPC6 participates in the ...
Hai-Tao Zhang +6 more
doaj +1 more source
A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section
JOR SPINE, Volume 9, Issue 2, June 2026.
Neharika Bhadouria +43 more
wiley +1 more source
TRPC3 and TRPC6 Contribute to the Pathogenesis of Hypertension
American Journal of Molecular Biology, 2015 Recently studies found that TRPC3 and TRPC6 played an important role in cardiovascular disease. Hypertension, as a cardiovascular disease causing the highest morbidity and mortality, has close relationship with the expressions of TRPC3 and TRPC6. Unbalanced calcium homeostasis is the major factor of pathogenesis of hypertension.
Qin Zou, Cui Zhang, Yuqing Guo
openaire +2 more sources
TRPC Channels in Proteinuric Kidney Diseases
Cells, 2019 Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
Gentzon Hall +2 more
doaj +1 more source