Results 91 to 100 of about 7,679 (208)

Cytoskeleton Rearrangements Modulate TRPC6 Channel Activity in Podocytes

, 2021
The actin cytoskeleton of podocytes plays a central role in the functioning of the filtration barrier in the kidney. Calcium entry into podocytes via TRPC6 (Transient Receptor Potential Canonical 6) channels leads to actin cytoskeleton rearrangement ...
Elena Kaznacheyeva, Alexander Staruschenko, Leonid S. Shuyskiy, Ruslan Bohovyk, Oleg Palygin, Alexey Shalygin   +5 more
core   +1 more source

TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics

Cells, 2019
Transient receptor potential canonical channel-6 (TRPC6) is one of the Ca2+-permeable non-selective cation channels. TRPC6 is mainly expressed in dentate granule cell (DGC), which is one of the most resistant neuronal populations to various harmful ...
Ji-Eun Kim, Hana Park, Seo-Hyeon Choi, Min-Jeong Kong, Tae-Cheon Kang   +4 more
doaj   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy

Journal of Nanobiotechnology
Background Glucocorticoid (GC) intolerance and systemic toxicity pose significant challenges in the treatment of primary nephrotic syndrome (PNS), underscoring the urgent need for targeted therapies that maximize efficacy while minimizing adverse effects.
Lin Wu, Yang Liu, Ziqi Fu, Honglei Guo, Kang Liu, Jiafa Ren, Zhimin Huang, Fang Yang, Huijuan Mao   +8 more
doaj   +1 more source

Performance of NIR‐Based Regression Models for Hyperforin Quantification in St. John's Wort Under Temporal Validation

Journal of Chemometrics, Volume 40, Issue 6, June 2026.
ABSTRACT This study investigates the performance of near‐infrared (NIR)‐based partial least squares (PLS) regression models for quantifying hyperforin in Hypericum perforatum L., with particular emphasis on temporal validation and robustness analysis. Dried and ground Hypericum samples were analyzed using three different NIR spectrometers: one benchtop
Nele‐Elin Schröter, Knut Baumann
wiley   +1 more source

Photopharmacology reveals high-specificity linkage of Ca2+ entry at TRPC6 nanodomains to NFAT activation in mast cells

Frontiers in Immunology
IntroductionPhotopharmacology has recently emerged as a strategy for high-precision modulation of immune functions. Here we explored efficiency and specificity of interventions based on light-induced TRPC6 activation in the RBL-2H3 mast cell model ...
Denis Krivić, Olga Panasiuk, Johannes Pilic, Roland Malli, Roland Malli, Bernadett Bacsa, Bernadett Bacsa, Sanja Ćurčić, Sanja Ćurčić, Klaus Groschner, Klaus Groschner   +10 more
doaj   +1 more source

Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6

Renal Failure, 2019
Objective: To investigate effects of combination use of leflunomide and benazepril on diabetic nephropathy (DN) both in vivo and in vitro. Methods: The streptozotocin (STZ) induced Sprague-Dawley rats were treated with leflunomide (15 mg/kg/d ...
Huili Li, Yuanyuan Wang, Zhangqing Zhou, Fang Tian, Huanhuan Yang, Juzhen Yan   +5 more
doaj   +1 more source

Inhibition of TRPC6 Signal Pathway Alleviates Podocyte Injury Induced by TGF-β1

Cellular Physiology and Biochemistry, 2017
Background/Aims: Transforming growth factor beta 1 (TGF-β1) plays a critical role in the pathogenesis of glomerulosclerosis. The purpose of this study was to examine the effects of inhibition of transient receptor potential cation channel C6 (TRPC6) on ...
Haiting Huang, Yanwu You, Xu Lin, Chunrong Tang, Xiangjun Gu, Meiying Huang, Youling Qin, Junhua Tan, Feifan Huang   +8 more
doaj   +1 more source

TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells

Channels, 2018
Store depletion has been shown to induce Ca2+ entry by Na+/Ca+ exchange (NCX) 1 reversal in proliferative vascular smooth muscle cells (VSMCs). The study objective was to investigate the role of transient receptor potential canonical (TRPC) channels in ...
Bin Zhang, Bei Liu, Carolyn M. Roos, Michael A. Thompson, Y. S. Prakash, Jordan D. Miller, Rui-wei Guo   +6 more
doaj   +1 more source

Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles.

PLoS ONE, 2020
α-Klotho is a type 1 transmembrane protein that exhibits aging suppression function. The large amino-terminal extracellular domain of α-klotho is shed as soluble klotho (sKlotho) and functions as a circulating cardioprotective hormone.
Jian Xie, Sung-Wan An, Xin Jin, Yuan Gui, Chou-Long Huang   +4 more
doaj   +1 more source