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Calculated incidence (%) of secondary structures of S100A1 and TRPC6_(801–878) WT and TRPC6 single mutant R852A and complex of TRPC6_(801–878) WT/S100A1.

, 2013
Calculated incidence (%) of secondary structures of S100A1 and TRPC6(801–878) WT and TRPC6 single mutant R852A and complex of TRPC6(801–878) WT/S100A1.
Kristyna Bousova (409729) +6 more
core +1 more source

Étude structure-activité du canal calcique TRPC6

Les canaux calciques « Transient receptor potential canonical 6 » (TRPC6) jouent un rôle important dans l'entrée du Ca2+ dans plusieurs processus physiologiques et pathologiques. Des mutations de type gain de fonction dans le gène TRPC6 conduisent à
Keshvari, Mahtab
core +1 more source

TRPC6-mediated calcium signaling is involved in T2DM-induced hepatic steatosis and fibrosis and the modulation of ginsenoside Rg1

Journal of Pharmacological Sciences
Hepatic steatosis and fibrosis represent major complications of type 2 diabetes mellitus (T2DM) with limited therapeutic options. Ginsenoside Rg1, a bioactive constituent of Panax ginseng, exhibits hepatoprotective properties, but its mechanism in ...
Haoyu Liang +7 more
doaj +1 more source

Mechanosensitivity of the TRPC6 ion channel

The transient receptor potential (TRP) ion channel family is a diverse group of channels gated by various physical and chemical stimuli. One of the members, TRPC6, is a cation channel, which is expressed in ventricular cardiomyocytes (CMs).
Yury A. Nikolaev (21276944)
core

The role of TRPC6 channels in renal fibrosis [PDF]

Metabolic syndrome presents a significant global public health challenge, closely linked to adverse renal and cardiovascular outcomes. Inhibition of TRPC6 has been identified as a potential therapeutic approach in mitigating renal complications ...
Xu, Yao
core +1 more source

Implication de l'ubiquitination dans la signalisation de TRPC6 [PDF]

, 2013
Le Ca[indice supérieur 2+] intracellulaire est impliqué dans un grand nombre de processus biologiques chez toutes les cellules de l’organisme. Chez les cellules non-excitables, les protéines TRPC, pour transient receptor potentiel canonical, situées à la
Phaneuf, Francis
core

Delivery of siRNAs Against Selective Ion Channels and Transporter Genes Using Hyaluronic Acid-coupled Carbonate Apatite Nanoparticles Synergistically Inhibits Growth and Survival of Breast Cancer Cells

International Journal of Nanomedicine
Mohammad Borhan Uddin,1 Mark M Banaszak Holl,2,3 Ezharul Hoque Chowdhury4,5 1Department of Pharmaceutical Sciences, School of Health and Life Sciences, North South University, Dhaka, Bangladesh; 2Department of Mechanical and Materials Engineering, School
Uddin MB, Holl MMB, Chowdhury EH
doaj

TRPC6 is a Biomarker for Prognosis and Immunotherapy of Stomach Adenocarcinoma Based on Bioinformatic Analysis and Experimental Validation

ImmunoTargets and Therapy
Xingchi Hu,1,2 Hongwei Wang,1,2 Haitao Sun,3 Jingxin Zhang,3 ZhenXiong Ye,4 Zhenhua Huang3 1Department of General Surgery, Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, Yancheng, Jiangsu, 224000, People’s Republic of ...
Hu X, Wang H, Sun H, Zhang J, Ye Z, Huang Z +5 more
doaj

Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression

We recently reported that transient receptor potential canonical (TRPC) 6 channel activity contributes to intracellular Zn2+ homeostasis in the heart. Zn2+ has also been implicated in the regulation of intestinal redox and microbial homeostasis.
Yuri Kato +7 more
core +1 more source

A novel TRPC6 variant (c.131C>T, p.(Pro44Leu)) associated with focal segmental glomerulosclerosis: a case report. [PDF]

Front Genet
Yang F +8 more
europepmc +1 more source

medicine