Results 101 to 110 of about 7,679 (208)

Soluble klotho selectively blocks DAG-stimulated TRPC6 exocytosis.

, 2020
(A) Diagram illustrating sKlotho selectively blocks exocytosis. (B-D) Effect of sKlotho on TRPC6 currents stimulated by BIRA0411XX or by OAG. HEK cells expressing recombinant TRPC6 channels were treated with sKlotho or vehicle overnight.
Yuan Gui (8538243), Sung-Wan An (8538240), Chou-Long Huang (623526), Xin Jin (108988), Jian Xie (629484)   +4 more
core   +1 more source

Expression of TRPC6 channels in human epithelial breast cancer cells [PDF]

, 2008
Background TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear.
Haren Nathalie, Guilbert Arnaud, Yassine EL Hiani, Halima Ouadid-Ahidouch, Henri Sevestre, Ahidouch Ahmed, Sevestre Henri, Arnaud Guilbert, Dhennin-Duthille Isabelle, Khorsi Hafida, Isabelle Dhennin-Duthille, Nathalie Haren, Hiani Yassine EL, Ahmed Ahidouch, Ouadid-Ahidouch Halima, Hafida Khorsi   +15 more
core   +2 more sources

The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis

Cellular Physiology and Biochemistry, 2016
Background/Aims: Although increased expression and gain function of transient receptor potential cation channel 6 (TRPC6) has been associated with the pathogenesis of some proteinuric glomerular diseases, it remains elusive how TRPC6 participates in the ...
Hai-Tao Zhang, Wei-Wei Wang, Li-Hong Ren, Xia-Xia Zhao, Zhi-Hui Wang, De-Li Zhuang, Yun-Nuo Bai   +6 more
doaj   +1 more source

Distribution of TRPC1, TRPC3, and TRPC6 in the human thyroid

Pathology - Research and Practice
Little is known about the protein expression of the transient receptor potential canonical (TRPC) channels 1, 3, and 6 in the thyroid. Research in human tissue is insufficient. Our aim was to investigate the distribution of TRPC1, 3, and 6 in the healthy human thyroid.Healthy samples were collected from seven nitrite pickling salt-ethanol-polyethylene ...
Kirstein, Emilie, Diebolt, Coline M., Wagner, Mathias, Bozzato, Alessandro, Federspiel, Jan M., Schaudien, Dirk, Tschernig, Thomas, Englisch, Colya N.   +7 more
openaire   +2 more sources

p53 directly binds to the TRPC6 promoter.

, 2013
A) EMSA is conducted to study the binding between p53 and its response element at the TRPC6 promoter under in-vitro conditions. A shift and a super-shift of the p53, p53AB and the p53-RE are observed in lane 2.
Uttam Pati (258033), Rajan Gogna (258030), Esha Madan (446812), Bernhard Keppler (446813)   +3 more
core   +1 more source

Vitamin D Down-Regulates TRPC6 Expression in Podocyte Injury and Proteinuric Glomerular Disease [PDF]

, 2013
Contains fulltext : 117939.pdf (Publisher’s version ) (Open Access)The transient receptor potential cation channel C6 (TRPC6) is a slit diaphragm protein expressed by podocytes.
Berden, J.H.M., Wetzels, J.F.M., Dijkman, H.B.P.M., Bindels, R.J.M., Sonneveld, R., Hoenderop, J.G.J., Vlag, J. van der, Nijenhuis, T., Ferre, S.   +8 more
core   +1 more source

TRPC Channels in Proteinuric Kidney Diseases

Cells, 2019
Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
Gentzon Hall, Liming Wang, Robert F. Spurney   +2 more
doaj   +1 more source

Podocin reguliert TRPC6 Ionenkanäle an der Schlitzmembran

, 2011
Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal disease. A variety of recent evidence supports the notion of the glomerular podocyte and the slit diaphragm as central components of the renal filtration barrier ...
Koos, Fabienne
core  

TRPC6 Regulates CXCR2-Mediated Chemotaxis of Murine Neutrophils

, 2013
Unraveling the mechanisms involved in chemotactic navigation of immune cells is of particular interest for the development of new immunoregulatory therapies.
Frank, Svetlana, Schimmelpfennig, Sandra, Hanley, Peter J., Schwab, Albrecht, Umlauf, Daniel, Fabian, Anke, Pap, Thomas, Dietrich, Alexander, Lindemann, Otto, Bertrand, Jessica   +9 more
core   +1 more source

Natural History and Clinicopathological Associations of TRPC6-Associated Podocytopathy [PDF]

Background:Understanding the genetic basis of human diseases has become integral to drug development and precision medicine. Recent advancements have enabled the identification of molecular pathways driving diseases, leading to targeted treatment ...
Colby, Elizabeth, Sampson, Matthew G, Appel, Gerald B, Martino, Jeremiah, Saleem, Moin A, Bomback, Andrew S, Saleem, Moin A., Ahram, Dina F, Mitrotti, Adele, Martinelli, Elena, Helmuth, Margaret E, Ke, Juntao, Osborne, Amy J., Ahram, Dina F., Paul, Dirk S, Osborne, Amy J, Delsante, Marco, Maggiore, Umberto, Gbadegesin, Rasheed, Feriozzi, Sandro, D'Agati, Vivette D, Zanoni, Francesca, Pisani, Isabella, Sahdeo, Sunil, Beenken, Andrew, Pollak, Martin R, Breckenridge, David, Ferrari, Massimo R A, Saida, Ken, Petrovski, Slavé, Armand, Farid, Hildebrandt, Friedhelm, Lim, Tze Y., Appel, Gerald B., Magistroni, Riccardo, Petrovski, Slav\ue9, Lane, Brandon, Rampino, Teresa, Goldstein, David B, Ferrari, Massimo R. A., Guglielmi, Francesca, Sanna-Cherchi, Simone, Lim, Tze Y, Jin, Gina, Knob, Andrea L, Esposito, Pasquale, Knob, Andrea L., Pollak, Martin R., Murtas, Corrado, Paul, Dirk S., Kretzler, Matthias, Kiryluk, Krzysztof, Gharavi, Ali G, Helmuth, Margaret E., Goldstein, David B., D'Agati, Vivette D., Ferrari, Massimo R.A., Wooden, Benjamin, Hall, Gentzon, Gharavi, Ali G., Fiaccadori, Enrico, Shril, Shirlee, Gesualdo, Loreto, Santoriello, Dominick, Wang, Chen, Sampson, Matthew G., Bomback, Andrew S.   +66 more
core   +2 more sources