Results 131 to 140 of about 6,014 (173)

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions. [PDF]

CNS Neurosci Ther
Guo D, Cai M, Xian Y, Chen Y, Feng Y, Hu C, Zeng L, Shi L, Zhang S.   +8 more
europepmc   +1 more source

TRPC6 in Human Peripheral Nerves-An Investigation Using Immunohistochemistry. [PDF]

NeuroSci
Raming C, Meier C, Tschernig T.
europepmc   +1 more source

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TRPC6

AfCS-Nature Molecule Pages, 2007
TRPC6 is a Ca(2+)-permeable non-selective cation channel expressed in brain, smooth muscle containing tissues and kidney, as well as in immune and blood cells. Channel homomers heterologously expressed have a characteristic doubly rectifying current-voltage relationship and are six times more permeable for Ca2+ than for Na+.
A, Dietrich, T, Gudermann
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TRPC6, a therapeutic target for pulmonary hypertension

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021
Idiopathic pulmonary arterial hypertension (PAH) is a fatal and progressive disease. Sustained vasoconstriction due to pulmonary arterial smooth muscle cell (PASMC) contraction and concentric arterial remodeling due partially to PASMC proliferation are the major causes for increased pulmonary vascular resistance and increased pulmonary arterial ...
Pritesh P. Jain, Ning Lai, Mingmei Xiong, Jiyuan Chen, Aleksandra Babicheva, Tengteng Zhao, Sophia Parmisano, Manjia Zhao, Cole Paquin, Moreen Matti, Ryan Powers, Angela Balistrieri, Nick H. Kim, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, John Y.-J. Shyy, Jian Wang, Joe G. N. Garcia, Ayako Makino, Jason X.-J. Yuan   +19 more
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The possible role of TRPC6 in atopic dermatitis

Medical Hypotheses, 2012
Skin barrier dysfunction is involved in the pathogenesis of atopic dermatitis (AD). The impaired barrier function is related to disturbed keratinocyte differentiation through improper Ca2+-regulated pathway in AD. Transient receptor potential canonical (subtype) 6 (TRPC6) is a Ca2+-permeable nonselective cation channel expressed in keratinocytes. TRPC6
Xiao-Dong, Sun, Yang, You, Li, Zhang, Song, Zheng, Yuxiao, Hong, Jie, Li, Xing-Hua, Gao   +6 more
openaire   +2 more sources

Improvement of platelet preservation by inhibition ofTRPC6

Transfusion Medicine, 2023
AbstractBackgroundThe preservation of platelets (PLTs) by room temperature (RT) oscillation limits their shelf life to between 4 and 7 days because of the decrease in PLT function. TRPC6 is a non‐selective mechanically sensitive cation channel that has been shown to mediate Ca2+signalling, implying a role in PLT activation during preservation by RT ...
Yuanjia Tan, Wei Lu, Xiaomei Yi, Huili Cai, Yurong Yuan, Shizhong Zhang   +5 more
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Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6

Journal of Ethnopharmacology, 2023
Liuwei Dihuang (LWDH) is a classic prescription that has been used to the treatment of "Kidney-Yin" deficiency syndrome for more than 1000 years in China. Recent studies have confirmed that LWDH can prevent the progression of renal fibrosis. Numerous studies have demonstrated the critical role that TRPC6 plays in the development of renal fibrosis.
Lei, Zhou, Kehan, Wu, Yuxuan, Gao, Ruizhi, Qiao, Na, Tang, Dianchao, Dong, Xiao-Qiang, Li, Qiuna, Nong, Ding-Qiang, Luo, Qianhan, Xiao, Xin, Fan, Qimei, Duan, Wei, Cao   +12 more
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Role of TRPC6 in Progression of Diabetic Kidney Disease [PDF]

Current Hypertension Reports, 2019
The underlining goal of this review is to offer a concise, detailed look into current knowledge surrounding transient receptor potential canonical channel 6 (TRPC6) in the progression of diabetic kidney disease (DKD).Mutations and over-activation in TRPC6 channel activity lead to the development of glomeruli injury.
Oleg Palygin, Alexander Staruschenko, Palygin Oleg   +2 more
exaly   +3 more sources

TRPC6 gene variants and neuropsychiatric lupus

Journal of Neuroimmunology, 2015
Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) influence patients' quality of life and their survival. Little is known about the pathophysiological bases of NPSLE and accordingly there are no specific therapeutic agents to be employed in this setting. Genetic research in systemic lupus erythematosus (SLE) is rapidly evolving as
Ramirez GA, Lanzani C, Bozzolo EP, Citterio L, Zagato L, Casamassima N, Canti V, Sabbadini MG, ROVERE QUERINI , PATRIZIA, MANUNTA , PAOLO, MANFREDI , ANGELO ANDREA M. A.   +10 more
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TRPC6-protein expression in the elderly and in liver disease

Annals of Anatomy - Anatomischer Anzeiger, 2023
The transient receptor potential canonical 6 (TRPC6) channel has been studied in pathologies of the hepatobiliary system. Information on the localization of TRPC6-protein in anatomical and histological structures of the human hepatobiliary system in elderly with and without liver disease is lacking.Samples were obtained from twelve nitrite pickling ...
Mariesa, Walz, Thomas, Tschernig, Peter, Schmidt, Jan M, Federspiel   +3 more
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