Results 141 to 150 of about 6,014 (173)
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VEGF regulates TRPC6 channels in podocytes
Nephrology Dialysis Transplantation, 2011Both, increased plasma concentrations of vascular endothelial growth factor (VEGF) and increased expression of transient receptor potential canonical type 6 (TRPC6) channels in podocytes have been associated with proteinuric kidney diseases. Now, we investigated the hypothesis that VEGF regulates TRPC6 in podocytes.TRPC6 messenger RNA (mRNA) and TRPC6 ...
Thilo, Florian +9 more
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Immunohistochemical localization of TRPC6 in the rat substantia nigra
Neuroscience Letters, 2007Transient receptor potential channels (TRPC) are plasma membrane, nonselective cationic channels and have been proposed as candidates involved in the regulation of cellular Ca2+ influx [D.E. Clapham, L.W. Runnels, C., Strubing, The TRP ion channel family, Nat. Rev. Neurosci. 2 (2001) 387-396; A. Martorana, C. Giampa, Z. DeMarch, M.T.
Giampà C +4 more
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TRPC6: Physiological Function and Pathophysiological Relevance
2014TRPC6 is a non-selective cation channel 6 times more permeable to Ca(2+) than to Na(+). Channel homotetramers heterologously expressed have a characteristic doubly rectifying current-voltage relationship and are directly activated by the second messenger diacylglycerol (DAG).
Alexander, Dietrich, Thomas, Gudermann
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STIM1 regulates TRPC6 heteromultimerization and subcellular location
Biochemical Journal, 2014STIM1 (stromal interaction molecule 1) regulates store-operated channels in the plasma membrane, but the regulation of TRPC (transient receptor potential canonical) heteromultimerization and location by STIM1 is poorly understood. STIM1 is a single transmembrane protein that communicates the filling state of the endoplasmic reticulum to store-operated ...
Letizia, Albarrán +5 more
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Targeting TRPC6 channels in oesophageal carcinoma growth
Expert Opinion on Therapeutic Targets, 2010Oesophageal carcinoma ranks among the ten most frequent cancers worldwide. The special growing site and malignant nature make it difficult to be completely treated by surgical operation and radiotherapy or chemotherapy. Discovery of new therapeutic targets responsible for the rapid proliferation of oesophageal carcinoma cells could help to treat this ...
Xia, Ding +4 more
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Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
International Journal of Molecular Sciences, 2023Elena Popugaeva, Nikita Zernov
exaly
TRPC6 channel and its implications in breast cancer: an overview
Biochimica Et Biophysica Acta - Molecular Cell Research, 2020Gines M Salido +2 more
exaly
An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis
Cellular and Molecular Life Sciences, 2023Maik Gollasch +2 more
exaly