Results 161 to 170 of about 7,679 (208)

Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons. [PDF]

CNS Neurosci Ther
Li T, Shen F, Li L, Chen P, Zhu Z, Zheng Y, Li H, Suo G, Wang Y, Shi J, Wu Y.   +10 more
europepmc   +1 more source

Mechanisms of Atrial Fibrillation in Heart Failure: Uncovering Therapeutic Targets in the Atrial Substrate. [PDF]

Curr Heart Fail Rep
Sultan D, Brundel BJJM.
europepmc   +1 more source

Cilostazol increases collateral remodeling and reduces the severity of ischemic stroke. [PDF]

J Cereb Blood Flow Metab
Zhang H, Ding MC, Gong G, Faber JE.
europepmc   +1 more source

Structural mechanism of TRPC3 inhibition by a potent and selective antagonist

Collingridge J, Cole BA, Liddle J, Gatfield KM, Biggin PC, Becker EBE.   +5 more
europepmc   +1 more source

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TRPC6

AfCS-Nature Molecule Pages, 2007
TRPC6 is a Ca(2+)-permeable non-selective cation channel expressed in brain, smooth muscle containing tissues and kidney, as well as in immune and blood cells. Channel homomers heterologously expressed have a characteristic doubly rectifying current-voltage relationship and are six times more permeable for Ca2+ than for Na+.
A, Dietrich, T, Gudermann
openaire   +3 more sources

TRPC6, a therapeutic target for pulmonary hypertension

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021
Idiopathic pulmonary arterial hypertension (PAH) is a fatal and progressive disease. Sustained vasoconstriction due to pulmonary arterial smooth muscle cell (PASMC) contraction and concentric arterial remodeling due partially to PASMC proliferation are the major causes for increased pulmonary vascular resistance and increased pulmonary arterial ...
Pritesh P. Jain, Ning Lai, Mingmei Xiong, Jiyuan Chen, Aleksandra Babicheva, Tengteng Zhao, Sophia Parmisano, Manjia Zhao, Cole Paquin, Moreen Matti, Ryan Powers, Angela Balistrieri, Nick H. Kim, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, John Y.-J. Shyy, Jian Wang, Joe G. N. Garcia, Ayako Makino, Jason X.-J. Yuan   +19 more
openaire   +2 more sources

TRPC6-protein expression in the elderly and in liver disease

Annals of Anatomy - Anatomischer Anzeiger, 2023
The transient receptor potential canonical 6 (TRPC6) channel has been studied in pathologies of the hepatobiliary system. Information on the localization of TRPC6-protein in anatomical and histological structures of the human hepatobiliary system in elderly with and without liver disease is lacking.Samples were obtained from twelve nitrite pickling ...
Mariesa, Walz, Thomas, Tschernig, Peter, Schmidt, Jan M, Federspiel   +3 more
openaire   +2 more sources

Improvement of platelet preservation by inhibition ofTRPC6

Transfusion Medicine, 2023
AbstractBackgroundThe preservation of platelets (PLTs) by room temperature (RT) oscillation limits their shelf life to between 4 and 7 days because of the decrease in PLT function. TRPC6 is a non‐selective mechanically sensitive cation channel that has been shown to mediate Ca2+signalling, implying a role in PLT activation during preservation by RT ...
Yuanjia Tan, Wei Lu, Xiaomei Yi, Huili Cai, Yurong Yuan, Shizhong Zhang   +5 more
openaire   +2 more sources

Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6

Journal of Ethnopharmacology, 2023
Liuwei Dihuang (LWDH) is a classic prescription that has been used to the treatment of "Kidney-Yin" deficiency syndrome for more than 1000 years in China. Recent studies have confirmed that LWDH can prevent the progression of renal fibrosis. Numerous studies have demonstrated the critical role that TRPC6 plays in the development of renal fibrosis.
Lei, Zhou, Kehan, Wu, Yuxuan, Gao, Ruizhi, Qiao, Na, Tang, Dianchao, Dong, Xiao-Qiang, Li, Qiuna, Nong, Ding-Qiang, Luo, Qianhan, Xiao, Xin, Fan, Qimei, Duan, Wei, Cao   +12 more
exaly   +3 more sources